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Circadian Rhythms, Cancers and Chronotherapy (2nd Edition)

A Special Issue of Cancers (ISSN 2072-6694) belonging to the section "Cancer Therapy".

Deadline for manuscript submissions: closed (30 June 2026) | Viewed by 1246

Editors


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Guest Editor
Cancer Chronotherapy Team, Division of Biomedical Sciences and Cancer Research Centre, Warwick Medical School, Warwick University, Coventry CV4 7AL, UK
Interests: circadian clocks; biological rhythms; chronopharmacology; chronotherapy
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Oncology Department, Ysbyty Gwynedd, Betsi Cadwaladr University Health Board, Bangor LL57 2PW, UK
2. Cancer Research Centre, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
3 UPR “Chronotherapy, Cancers and Transplantation”, Faculty of Medicine, Paris-Saclay University, 94800 Villejuif, France
Interests: cancer chronotherapeutics; circadian rhythms; supportive care; digital health
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
Interests: sleep disorders
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is the second edition of a previous Special Issue on the topic of “Circadian rhythms, Cancers and Chronotherapy” (https://www.mdpi.com/journal/cancers/special_issues/2NS03XTM5G) This Special Issue aims to advance precision and personalized cancer medicine. Taking into consideration this goal, we invite you to submit original or review scientific or biomedical articles on these topics. We welcome original contributions reporting new challenging scientific results and/or highlighting novel approaches regarding the molecular, cellular, and physiologic interactions between circadian rhythms and cancer processes and treatments, as well as their healthcare implications. Indeed, a hierarchical network of cellular clocks, consisting of a system of 15 clock genes, orchestrates cellular metabolism, proliferation, and survival, as well as physiology and responses to therapeutic agents, over a 24 h timescale. Accumulating evidence supports an important role of circadian rhythms both for carcinogenesis processes from initiation to progression and metastasis, and for the tolerability and efficacy of all kinds of cancer treatments. However, circadian rhythms can differ as a function of sex, age, environment, genetics, or other biological factors in experimental cancer models, among people at risk of cancer, and among cancer patients. Manuscripts on the relevance of circadian or other biological clocks in the following research areas may include (but are not limited to) the following topics:

  • In vitro and in vivo experimental cancer models;
  • Drug development and chronotherapy;
  • Chemotherapy, immunotherapy, targeted agents, radiotherapy, surgery;
  • Circadian host or tumor biomarkers;
  • Electronic patient-reported outcomes;
  • Circadian rhythms and sleep;
  • Sex- and age specificities;
  • Clinical trial designs;
  • Mathematical models and artificial intelligence;
  • Digital healthcare, telemedicine and logistics.

We look forward to receiving your contributions. 

Prof. Dr. Francis Levi
Dr. Pasquale F. Innominato
Dr. Esra Tasali
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug development and chronotherapy
  • chemotherapy, immunotherapy, targeted agents, radiotherapy, surgery
  • circadian host or tumor biomarkers
  • electronic patient-reported outcomes
  • circadian rhythms and sleep
  • sex- and age specificities
  • clinical trial designs
  • mathematical models and artificial intelligence
  • digital healthcare, telemedicine and logistics

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Published Papers (1 paper)

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Review

20 pages, 5451 KB  
Review
Can Disruption of Circadian Rhythms Be Linked to Radiation-Induced Acute Myeloid Leukaemia?
by Aleksandra Czyzak, Gráinne O’Brien, Milagrosa Lopez-Riego, Lourdes Cruz-Garcia and Christophe Badie
Cancers 2026, 18(14), 2255; https://doi.org/10.3390/cancers18142255 - 14 Jul 2026
Viewed by 676
Abstract
Acute myeloid leukaemia (AML) remains a highly lethal malignancy with poor prognosis in adults above 60 years old and often occurs after radiation exposure. Emerging evidence suggests that circadian rhythm disruption, prevalent in shift workers, may contribute to cancer development. Clock genes (CGs) [...] Read more.
Acute myeloid leukaemia (AML) remains a highly lethal malignancy with poor prognosis in adults above 60 years old and often occurs after radiation exposure. Emerging evidence suggests that circadian rhythm disruption, prevalent in shift workers, may contribute to cancer development. Clock genes (CGs) regulate fundamental cellular processes, including the DNA damage response (DDR), cell cycle progression, and haematopoiesis. In the absence of substantial experimental data, this review examines the potential pathways linking circadian clock dysregulation to radiation-induced AML (rAML) and evaluates how temporal disruption may modulate leukaemogenesis and radiation-induced effects. The evidence was synthesised on core clock components (BMAL1, CLOCK, PER, CRY, REV-ERB, ROR), their dysregulation in AML, and their roles in radiation response. Epigenetic and post-transcriptional regulatory mechanisms, including m6A RNA modification and sirtuin-mediated chromatin remodelling, were evaluated for their contribution to circadian-regulated DNA repair capacity. Multiple CGs demonstrated aberrant expression in AML, with BMAL1 showing tissue-specific dysregulation, and PER1/2/3 was consistently downregulated in peripheral blood. Clock proteins directly regulate DNA damage checkpoints through interactions with ATM/CHK2 and p53 pathways. Circadian disruption enhances inflammatory signalling, promotes accumulation of myeloid-derived suppressor cells, and accelerates immune senescence. Moreover, radiation exposure modulates CG expression, which may alter repair fidelity and increase leukaemogenic risk. Understanding these connections in the context of disrupted circadian rhythms could help identify at-risk populations and improve shift workplace health policies. Full article
(This article belongs to the Special Issue Circadian Rhythms, Cancers and Chronotherapy (2nd Edition))
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