Evolving Management of Gastroesophageal Cancers: From Local Therapies to Precision Oncology
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: 30 June 2026 | Viewed by 46
Special Issue Editor
Interests: gastric cancer; esophageal cancers; hepatocellular carcinoma; biliary cancer; gallbladder cancer; immunotherapy; targeted therapy; precision medicine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Gastroesophageal cancers—including gastric, gastroesophageal junction (GEJ), and esophageal squamous cell and adenocarcinomas—are among the most prevalent gastrointestinal malignancies worldwide, posing high mortality rates. Management often requires a multidisciplinary approach, integrating surgery, systemic therapy, and radiation.
For early-stage disease, endoscopic resection may be curative in select superficial tumors, while esophagectomy or gastrectomy remains standard for locally advanced resectable cases. Minimally invasive techniques are increasingly used to reduce morbidity. Radiation therapy serves both definitive and perioperative roles, particularly in squamous histology or when surgery is not feasible. Multimodal treatment strategies are fundamental across both localized and advanced disease. In resectable cases, management typically combines systemic therapy, surgery, and/or radiation. For unresectable or metastatic disease, systemic therapy remains the cornerstone and is increasingly guided by molecular and immunologic biomarkers. Chemotherapy is routinely used, either alone or in combination with immune checkpoint inhibitors such as nivolumab or pembrolizumab, selected based on PD-L1 CPS, MSI, and MMR status. HER2-targeted agents (trastuzumab, trastuzumab deruxtecan) and CLDN18.2-directed therapies (e.g., zolbetuximab) are transforming care in molecularly defined subgroups. Additional investigational approaches include antibody–drug conjugates (ADCs), bispecific antibodies, and CAR-T cells. Radiation therapy, endoscopic stenting, and best supportive care also play important roles depending on disease burden, symptoms, and performance status.
This Special Issue welcomes original research and reviews focused on innovations and challenges across the spectrum of gastroesophageal cancer care, including surgical, radiation, systemic, molecular, and supportive approaches.
Dr. Ilyas Sahin
Guest Editor
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Keywords
- gastric cancer
- esophageal cancer
- immunotherapy targeted therapy
- radiation therapy
- surgical oncology
- precision oncology
- molecular biomarkers
- multimodal treatment
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