The Extracellular Matrix and Tissue Engineering: Roles in the Tumor Microenvironment and Implications for Cancer Treatment
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 51
Special Issue Editors
Interests: oncology; matrix stiffness; integrin activity; adhesions; drug discovery; cell metabolism
Special Issues, Collections and Topics in MDPI journals
Interests: cancer models; 3D models; fibrosis; matrix stiffness; pancreatic cancer; liver cancer; ovarian cancer
Interests: lung cancer; cancer signaling; extracellular matrix; matrix stiffness; adhesions; drug resistance; cell metabolism
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The extracellular matrix (ECM) consists of a dynamic network of fibrous proteins and polysaccharides and provides structural support to cells and tissues. In the context of cancer, the ECM undergoes remodeling driven both by cancer cells and stromal cells, such as fibroblasts, endothelial cells and immune cells. ECM remodeling involves the excessive deposition, degradation, and crosslinking of ECM components, leading to a stiffened microenvironment.
In this Special Issue of Cancers, we welcome the submission of research papers as well as expert reviews that are focused on, but not limited to, studying the interactions between the ECM with cancer cells and stromal cells, and their impact on tumor progression, metastasis, and drug resistance; fabricating models to study the role of ECM in cancer, including tissue engineering approaches for recreating the tumor microenvironment; and identifying innovative therapeutic strategies targeting the ECM.
Dr. Maria Georgiadou
Prof. Dr. Eirini Velliou
Dr. Eugenia Roupakia
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- extracellular matrix remodeling
- stiffness
- cancer progression
- tumor metastasis
- tissue engineering
- 3D models
- anti-cancer therapies
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