Tumor Microenvironment of Thyroid Carcinoma
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: 30 June 2026 | Viewed by 2
Special Issue Editor
Special Issue Information
Dear Colleagues,
Thyroid cancer, while often exhibiting favorable outcomes, can demonstrate aggressive behavior and treatment resistance, particularly in advanced or dedifferentiated subtypes. Understanding this heterogeneity requires looking beyond the malignant cells themselves to the intricate ecosystem they inhabit: the tumor microenvironment (TME). The TME is a dynamic and complex network comprising non-cancerous cells (immune cells like lymphocytes, macrophages, dendritic cells; cancer-associated fibroblasts; endothelial cells), extracellular matrix components, signaling molecules (cytokines, chemokines, growth factors), and physical conditions (hypoxia, acidity).
In thyroid cancer, the composition and function of the TME play a pivotal role in tumor initiation, progression, invasion, metastasis, and response to therapy. The interactions between cancer cells and their microenvironment are bidirectional and shape critical processes like immune evasion, angiogenesis, extracellular matrix remodeling, and metabolic reprogramming. Notably, the TME's characteristics vary significantly across thyroid cancer subtypes, contributing to their distinct clinical behaviors. Deciphering the complex cellular and molecular crosstalk within the thyroid carcinoma TME is thus essential for uncovering novel therapeutic targets and biomarkers to improve patient management, especially for treatment-resistant cases.
Dr. Juan Carlos Jaume
Guest Editor
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Keywords
- thyroid cancer
- tumor immune microenvironment (TIME)
- double-negative T cells (DN T cells)
- tumor-associated macrophages (TAMs)
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