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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Disparities in Thoracic Oncology Patients
edited by Jeffrey B. Velotta and
submission deadline 30 Nov 2025 | Viewed by 319 | Submission Open
Keywords: lung cancer; disparities; thoracic oncology
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Non-Coding RNAs and Extracellular Vesicles in Cancer Crosstalk: Diagnostic and Therapeutic Implications 2nd Edition submission deadline 30 Nov 2025 | Viewed by 304 | Submission Open
Keywords: extracellular vesicles; exosomes; cancer; inflammation; non-coding RNA; microRNAs; circular-RNAs; PIWI-RNAs; lnc-RNAs
(This special issue belongs to the Section Cancer Therapy)
Gastric Cancers: Molecular Mechanisms, Novel Targets and Immunotherapies: From Bench to Clinical Therapeutics (2nd Edition) submission deadline 30 Nov 2025 | Viewed by 255 | Submission Open
Keywords: novel oncogene targets; interplay among cancer; stroma; and immune cells; tumor microenvironment (TME); immune biomarker; immunotherapy; new therapeutic modality; translational research; clinical trials
(This special issue belongs to the Section Molecular Cancer Biology)
New Approaches in Modulating Transcription Factors for Cancer Therapy: 2nd Edition
edited by
submission deadline 30 Nov 2025 | Viewed by 247 | Submission Open
Keywords: transcription factors; cancer treatment; degraders; inhibitors
(This special issue belongs to the Section Cancer Therapy)
PET/CT in Radiation Oncology
edited by Gurdip Azad and
submission deadline 30 Nov 2025 | Viewed by 209 | Submission Open
Keywords: PET-CT; radiation oncology; theranostics; artificial intelligence; personalised care; tumour volume delineation; adaptive radiotherapy
(This special issue belongs to the Section Methods and Technologies Development)
Integrin Beta-1 Signaling in Cancers
edited by Adama Sidibé and Bernhard Wehrle-Haller
submission deadline 30 Nov 2025 | Viewed by 164 | Submission Open
Keywords: integrin beta-1; cancer cell; tissue stroma; fibrosis; talin-1; paxillin; kinases; acetyltransferases; FAK; SRC kinase; SFK; cell proliferation; adhesion; migration; drug resistance
(This special issue belongs to the Section Molecular Cancer Biology)
Gastrointestinal and Its Associated Malignancies: Diagnosis, Targets and Therapies
edited by Ganji P. Nagaraju and
submission deadline 1 Dec 2025 | 3 articles | Viewed by 9380 | Submission Open
Keywords: GI cancers; oncogenesis; diagnosis; target identification; biomarkers; therapy
(This special issue belongs to the Section Cancer Therapy)
Clinical Studies in Gastrointestinal Malignancies submission deadline 1 Dec 2025 | 4 articles | Viewed by 7348 | Submission Open
Keywords: gastrointestinal cancers; clinical studies; multimodal treatment; study design; outcomes
(This special issue belongs to the Section Clinical Research of Cancer)
Post-transcriptional Regulation of Cancer-Related Processes
edited by
submission deadline 1 Dec 2025 | 1 articles | Viewed by 3476 | Submission Open
Keywords: microRNAs; long-non-coding RNA; RNA-binding proteins; stress granules; P-bodies
(This special issue belongs to the Section Tumor Microenvironment)
Latest Breakthroughs in Tumor Immune Microenvironment: From Cellular Discovery to Cutting-Edge Technology submission deadline 5 Dec 2025 | 5 articles | Viewed by 12837 | Submission Open
Keywords: tumor microenvironment; natural food extracts; molecular markers; abscopal effect; RT technology; prognosis; side effects and abscopal effects
(This special issue belongs to the Section Tumor Microenvironment)
Mesothelioma—from Diagnosis to Treatment
edited by
submission deadline 5 Dec 2025 | 4 articles | Viewed by 11094 | Submission Open
Keywords: asbestos; BAP-1; CAR-T; CTLA-4; immunotherapy; mesothelioma; PD-1; PD-L1
(This special issue belongs to the Section Cancer Therapy)
Paradigm Shifts in Gynaecological Oncology Surgery
edited by
submission deadline 5 Dec 2025 | 3 articles | Viewed by 6101 | Submission Open
Keywords: gynecological surgery; genomics risk management; survivorship health economics
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
NK Cells in the Tumor Microenvironment: Immunosuppressive Mechanisms and Therapy
edited by and Julian Vivian
submission deadline 5 Dec 2025 | 2 articles | Viewed by 3876 | Submission Open
Keywords: immunosuppression; activation; inhibition; receptor; NK-CAR; checkpoint; adoptive cell therapy; immunotherapy; tumor microenvironment; nanoparticles
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Clinical Research on Thoracic Cancer
edited by and Hiroyuki Adachi
submission deadline 6 Dec 2025 | 3 articles | Viewed by 5905 | Submission Open
Keywords: thoracic cancer; lung cancer; thymic cancer; malignant mesothelioma; radiotherapy; surgery; chemotherapy; immunotherapy; driver mutation
(This special issue belongs to the Section Clinical Research of Cancer)
Preclinical and Clinical Research on the Efficacy of Anticancer Drugs
edited by Andrzej Hellmann, Joanna Jakobkiewicz-Banecka and Jan Lica
submission deadline 10 Dec 2025 | 2 articles | Viewed by 6473 | Submission Open
Keywords: clinical trials; preclinical research; anticancer drugs; drug efficacy; drug development; cancer therapy; therapeutic strategies; safety assessment; pharmacodynamics; pharmacokinetics
(This special issue belongs to the Section Clinical Research of Cancer)
New Advances in Oncology Research and Practice
edited by
submission deadline 10 Dec 2025 | 1 articles | Viewed by 1395 | Submission Open
Keywords: cancer bioinformatics; cancer biology; cancer diagnosis; cancer genomics; cancer immunotherapy; corona virus and cancer; cancer molecular mechanisms; organ-specific cancers; palliative cancer care
(This special issue belongs to the Section Cancer Therapy)
The Impact of Treatment Resistance in Prostate Cancer
edited by
submission deadline 10 Dec 2025 | Viewed by 206 | Submission Open
Keywords: prostate cancer; treatment resistance; progression; drug target; targeted therapy
(This special issue belongs to the Section Cancer Therapy)
Diagnosis of Hematologic Malignancies: 2nd Edition submission deadline 10 Dec 2025 | Viewed by 157 | Submission Open
Keywords: diagnosis of hematologic malignancies; myeloid neoplasms; lymphoid neoplasms; cytomorphology; flow cytometry; cytogenetic; molecular biology
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Prostate Cancer Metastasis—Diagnosis and Treatment
edited by Arnulf Stenzl
submission deadline 12 Dec 2025 | 1 articles | Viewed by 952 | Submission Open
Keywords: prostate cancer; metastasis; hormone-sensitive; castration-resistant prostate cancer; imaging; PSMA; ligand therapy; sequence; oligometastatic; biomarker
(This special issue belongs to the Section Cancer Metastasis)
Role of Cancer Biomarkers for Diagnosis, Prognosis and Targeted Therapy in Gastrointestinal Cancers
edited by
submission deadline 13 Dec 2025 | 8 articles | Viewed by 10575 | Submission Open
Keywords: liquid biopsy; esophageal cancer; gastric cancer; colorectal cancer; pancreatic cancer; hepatocellular cancer; appendiceal cancer; cancer biomarker; DNA sequencing; transcriptomics; proteomics; immunohistochemistry
(This special issue belongs to the Section Cancer Biomarkers)
Clinical Treatment and Prognostic Factors of Urologic Cancer
edited by
submission deadline 15 Dec 2025 | 13 articles | Viewed by 36129 | Submission Open
Keywords: prostate cancer; bladder cancer; urothelial carcinoma; upper urinary tract tumors; kidney cancer; renal cell carcinoma; testicular tumors; molecular markers; diagnosis; systemic treatment
(This special issue belongs to the Section Cancer Therapy)
New Biomarkers in Cancers 2nd Edition
edited by
submission deadline 15 Dec 2025 | 13 articles | Viewed by 29900 | Submission Open
Keywords: cancer; biomarker; molecule; serum; tumor; liquid biopsy; circulating tumor DNA; DNA; RNA; protein; circulating tumor cells; prognosis; prediction; indicator; traceable substance
(This special issue belongs to the Section Cancer Biomarkers)
Biomarkers for Treatment Prediction, Prognosis and Early Detection of Gynecologic Cancer
edited by Brian S Finkelman, Rachelle P Mendoza and Hani Katerji
submission deadline 15 Dec 2025 | 10 articles | Viewed by 21866 | Submission Open
Keywords: biomarkers; endometrial cancer; uterine cancer; cervical cancer; ovarian cancer; vulvar cancer; treatment prediction; prognosis; early detection
(This special issue belongs to the Section Cancer Biomarkers)
Molecular Markers and Targeted Therapy for Hepatobiliary Tumors
edited by Masaki Kuwatani
submission deadline 15 Dec 2025 | 7 articles | Viewed by 20309 | Submission Open
Keywords: cholangiocarcinoma; hepatocellular carcinoma; molecule; gene; chemotherapy; phototherapy
(This special issue belongs to the Section Cancer Therapy)
Advances in Epidermal Growth Factor Receptor-Driven Non-Small-Cell Lung Cancer: Diagnostic Technologies and Therapeutic Strategies
edited by
submission deadline 15 Dec 2025 | 4 articles | Viewed by 14487 | Submission Open
Keywords: EGFR-targeted therapy; non-small-cell lung cancer diagnosis; diagnostic technologies and devices; biological discoveries in NSCLC; AI-assisted diagnosis in oncology; clinical practice in NSCLC detection; therapeutic– diagnostic integration; early-stage lung cancer monitoring; advanced NSCLC diagnostic approaches; precision medicine in lung cancer
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
New Molecular Targets and Emerging Approaches to Target Cancer Stem Cells
edited by and Mónica Fernandes
submission deadline 15 Dec 2025 | 4 articles | Viewed by 11924 | Submission Open
Keywords: cancer stem cells; plasticity; microenvironmental heterogeneity; resistance to therapy; targeted therapies; immune surveillance avoidance; invasion; metastasis
(This special issue belongs to the Section Tumor Microenvironment)
Genome Instability and Human Cancer
edited by Jian Ouyang
submission deadline 15 Dec 2025 | 3 articles | Viewed by 11367 | Submission Open
Keywords: genomic instability; cancer progression; drug resistance; tumor-targeted immunity
(This special issue belongs to the Section Tumor Microenvironment)
Advances in B-Cell Lymphoma: From Diagnostics to Cure
edited by and Megan E. Melody
submission deadline 15 Dec 2025 | 5 articles | Viewed by 10203 | Submission Open
Keywords: B-cell lymphoma; treatment; molecular profiling; immunotherapies; cellular therapies
(This special issue belongs to the Section Cancer Therapy)
Endometrial Cancer—Diagnosis and Treatment submission deadline 15 Dec 2025 | 3 articles | Viewed by 4809 | Submission Open
Keywords: endometrial cancer; Lynch syndrome; oncology; sentinel lymph node; uterine cancer; molecular classification
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Outcome Analysis and Predictive Insights in Soft Tissue Sarcomas: leveraging Clinical Data and Integrating Modelling
edited by
submission deadline 15 Dec 2025 | 2 articles | Viewed by 3640 | Submission Open
Keywords: bone sarcomas; soft tissue sarcomas; outcome analysis; predictive modelling; prognostic biomarkers; therapeutic impact; clinical data integration; survivorship prediction; patient trajectories; sarcoma management
(This special issue belongs to the Section Methods and Technologies Development)
Incorporating DNA Damage Response (DDR) Mechanisms in Cancer Systems: 2nd Edition submission deadline 15 Dec 2025 | 1 articles | Viewed by 2961 | Submission Open
Keywords: complex DNA damage; methodologies for detection of DNA damage; DNA damage response (DDR) and repair; biological effects of radiation stress; oxidative stress; and replication stress; DDR and immune response; genomic instability; aging; bioinformatics and systems biology; machine learning and artificial intelligence; cancer survival and therapeutics; 3D bioprinting of cells and tissues
(This special issue belongs to the Section Molecular Cancer Biology)
Surgical Management of Non-Small Cell Lung Cancer
edited by József Furák
submission deadline 15 Dec 2025 | 4 articles | Viewed by 2927 | Submission Open
Keywords: non-small cell lung cancer; surgery; treatment; segmentectomy
(This special issue belongs to the Section Cancer Therapy)
Multicellular 3D Models of Cancer submission deadline 15 Dec 2025 | 2 articles | Viewed by 2620 | Submission Open
Keywords: 3D in vitro cancer models; multicellular cancer models; cancer microenvironment; tumour– stroma interactions
(This special issue belongs to the Section Methods and Technologies Development)
Signaling Pathways in Breast Cancer: 2nd Edition
edited by
submission deadline 15 Dec 2025 | 1 articles | Viewed by 2092 | Submission Open
Keywords: angiogenesis; apoptosis; breast cancer metastasis; breast cancer stem cells; cancer invasion; chemoprevention; epithelial-to-mesenchymal transition; ERα /ERBB2/HER2/NFκ B/Notch3/TGFβ signaling; mammary carcinogenesis; mitochondrial dynamics; tumor microenvironment
(This special issue belongs to the Section Cancer Therapy)
Advances in Genomics and Molecular Diagnostics in Gynecological Pathology
edited by and
submission deadline 15 Dec 2025 | 2 articles | Viewed by 2080 | Submission Open
Keywords: tumor genomics; molecular diagnosis; targeted therapies; biomarkers
(This special issue belongs to the Section Molecular Cancer Biology)
Thoracic Neuroendocrine Tumors and the Role of Emerging Therapies submission deadline 20 Dec 2025 | 4 articles | Viewed by 12126 | Submission Open
Keywords: thoracic neuroendocrine tumors; lung NETs; low-grade typical carcinoids; TCs; intermediate-grade atypical carcinoids; ACs; high-grade large cell neuroendocrine carcinoma LCNEC; small cell lung carcinoma (SCLC) neuroendocrine carcinoma
(This special issue belongs to the Section Cancer Therapy)
Optimizing Surgical Procedures and Outcomes in Renal Cancer
edited by and Piotr Kania
submission deadline 20 Dec 2025 | 6 articles | Viewed by 8497 | Submission Open
Keywords: renal cancer surgery; optimizing outcomes; minimally invasive techniques; surgical innovations; multidisciplinary approaches
(This special issue belongs to the Section Clinical Research of Cancer)
Gynecological Cancer: Prevention, Diagnosis, Prognosis and Treatment
edited by Joanna P. Kacperczyk-Bartnik, Tibor Andrea Zwimpfer and
submission deadline 20 Dec 2025 | 3 articles | Viewed by 4665 | Submission Open
Keywords: gynecological cancer; ovarian cancer; cervical cancer; endometrial cancer; early diagnosis; cancer prevention; prognosis; molecular mechanisms; personalized medicine; novel therapies
(This special issue belongs to the Section Clinical Research of Cancer)
Diagnosis and Therapeutic Management of Gastrointestinal Cancers: 2nd Edition submission deadline 20 Dec 2025 | 2 articles | Viewed by 3909 | Submission Open
Keywords: esophagus tumor; stomach tumor; liver tumor; colon tumor; rectum tumor; pancreato-biliary tumor; targeted immune and/or chemotherapy; surgical technology; multimodal approach; diagnosis; therapeutic management
(This special issue belongs to the Section Cancer Therapy)
Histopathology and Pathogenesis of Skin Cancer submission deadline 20 Dec 2025 | 2 articles | Viewed by 3255 | Submission Open
Keywords: skin; tumor; cancer; histopathology; pathogenesis; molecular; immunohistochemistry; pathway; pathology
(This special issue belongs to the Section Cancer Pathophysiology)
Insights into the Pathogenesis of Cutaneous T-Cell Lymphoma and the Impact of These Potential Biomarkers on Future Diagnosis, Prognosis and Treatment
edited by Sean Whittaker
submission deadline 20 Dec 2025 | 2 articles | Viewed by 2588 | Submission Open
Keywords: primary cutaneous T-cell lymphomas; CTCL; pathogenesis; biomarkers; diagnosis; prognosis; treatment
(This special issue belongs to the Section Cancer Biomarkers)
A Deeper Dive into Signaling Pathways in Cancers (2nd Edition)
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1628 | Submission Open
Keywords: signaling pathways; cancer; drug resistance; tumor microenvironment; molecularly targeted drug; epigenetic regulation; reverse-phase protein array
(This special issue belongs to the Section Tumor Microenvironment)
The Impact of Minimally Invasive Surgery on Gynecologic Cancers
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1070 | Submission Open
Keywords: minimally invasive surgery; robotic-assisted surgery; gynecologic malignancy; laparoscopy
(This special issue belongs to the Section Cancer Therapy)
IBD-Associated Cancer
edited by Takayuki Ogino
submission deadline 20 Dec 2025 | Viewed by 292 | Submission Open
Keywords: IBD-associated cancer; Crohn’ s disease; ulcerative colitis; colorectal cancer; small bowel cancer; chemotherapy; radiotherapy
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Translational Cancer Research in Multiple Myeloma, with a Focus on Immune Therapies and Novel Agents – “The Bench Behind the Bedside”
edited by Paul G. Richardson, and Shonali Midha
submission deadline 20 Dec 2025 | Viewed by 165 | Submission Open
Keywords: multiple myeloma; immune microenvironment; signaling pathways; therapeutic targets; immune effector cell therapies; monoclonal antibodies; targeted agents; mechanisms of action; resistance mechanisms; treatment
(This special issue belongs to the Section Cancer Therapy)
Metastasis Associated Long Noncoding RNAs in Cancer Research
edited by
submission deadline 21 Dec 2025 | Viewed by 332 | Submission Open
Keywords: lncRNA; metastasis; invasion; gene regulation; gene expression signature
(This special issue belongs to the Section Cancer Metastasis)
Tumor Immune Microenvironment in Gastric Cancers submission deadline 25 Dec 2025 | 4 articles | Viewed by 17122 | Submission Open
Keywords: tumor immune microenvironment; gastric cancer; therapeutic strategies; therapeutic response; tumor-associated macrophages
(This special issue belongs to the Section Tumor Microenvironment)
Study on Epidemiology of Childhood Cancer submission deadline 25 Dec 2025 | 5 articles | Viewed by 12942 | Submission Open
Keywords: childhood cancer; epidemiology; childhood cancer registries; incidence; prevalence; mortality; survival; time trends; special analysis; environmental factors; perinatal factors; inequalities
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Advances in Ovarian Cancer Research and Treatment: 2nd Edition
edited by
submission deadline 25 Dec 2025 | 3 articles | Viewed by 6211 | Submission Open
Keywords: ovarian carcinoma metastasis; mechanisms of dissemination; chemotherapy resistance; novel treatments and therapeutic approaches; novel molecular targets
(This special issue belongs to the Section Cancer Therapy)
Advancements in the Diagnosis and Surgical Treatment of Prostate Cancer
edited by and Christian Thomas
submission deadline 25 Dec 2025 | 3 articles | Viewed by 5335 | Submission Open
Keywords: robotic-assisted radical prostatectomy; significance of pelvic lymph node dissection in the context of radical prostatectomy; complications of surgical therapy for prostate cancer; magnetic resonance imaging/ultrasound-guided target biopsy of the prostate; comparison of various robotic systems for radical prostatectomy; learning curves; hospital volume; prostate cancer centers
(This special issue belongs to the Section Clinical Research of Cancer)
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