Immune–Genomic Interactions and Risk Stratification in Hormone-Receptor-Positive Breast Cancer
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: 31 August 2026 | Viewed by 102
Special Issue Editor
Interests: hormone-receptor-positive breast cancer; triple-negative breast cancer; tumor-infiltrating lymphocytes; tumor immune microenvironment; translational breast cancer research
Special Issue Information
Dear Colleagues,
Hormone-receptor-positive (HR-positive) breast cancer represents the most common subtype of breast cancer and is characterized by substantial clinical and biological heterogeneity. While multigene expression assays such as Oncotype DX have become central to prognostic assessment and treatment decision-making, discordance between conventional clinicopathological risk and genomic risk is frequently observed in routine practice. The biological basis of this discordance, particularly in relation to the tumor immune microenvironment, remains incompletely understood.
Recent evidence suggests that tumor-infiltrating lymphocytes (TILs), although generally sparse in HR-positive disease, may preferentially align with intrinsic genomic programs rather than with traditional clinical risk stratification. Emerging concepts such as immune–genomic decoupling highlight the need to re-evaluate tumor immunity, genomic signatures and clinical risk as integrated—but not always concordant—dimensions of tumor biology.
This Special Issue aims to provide a comprehensive platform for original research and reviews addressing immune–genomic interactions, risk stratification and translational implications in HR-positive breast cancer. Topics of interest include, but are not limited to, tumor immune microenvironment profiling, genomic assays and immune signatures, clinical–genomic discordance, biomarkers of treatment response and novel frameworks for precision oncology.
We welcome contributions that advance biological understanding and clinical translation in this evolving field.
Dr. Shinichiro Kashiwagi
Guest Editor
Manuscript Submission Information
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Keywords
- hormone-receptor-positive breast cancer
- oncotype DX
- tumor-infiltrating lymphocytes
- immune–genomic interaction
- clinical–genomic discordance
- tumor microenvironment
- precision medicine
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