Breast Cancer: Immune Response, Immune Microenvironment, and Immunotherapy
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Immunology and Immunotherapy".
Deadline for manuscript submissions: 15 September 2026 | Viewed by 4
Special Issue Editors
Interests: breast cancer; immunotherapy resistance; checkpoint blockade; immune cells
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Breast cancer remains a leading cause of cancer-related mortality, with growing research emphasizing its complex interaction with the immune system. The immune response and tumor immune microenvironment (TIME) significantly influence disease progression and therapeutic outcomes. Immunotherapy approaches, including immune checkpoint inhibitors, cancer vaccines, and adoptive T-cell therapy, have shown promise, though resistance remains a major challenge. This resistance stems from both intrinsic mechanisms (genetic mutations, tumor heterogeneity, antigen loss) and extrinsic factors (immunosuppressive microenvironment, dysfunctional immune cell infiltration).
This Special Issue will explore the diverse mechanisms of resistance in breast cancer immunotherapy, with a particular focus on the pivotal role of patient stratification based on immune profiles. By categorizing patients according to distinct immunological characteristics, this Special Issue will deepen our understanding of how these classifications influence therapeutic outcomes. Furthermore, it will synthesize current evidence linking immune-based patient subgroups to differential treatment responses, ultimately advocating for biomarker-driven strategies that enhance the precision and effectiveness of personalized immunotherapy in breast cancer.
Dr. Ravindra Deshpande
Prof. Dr. Ann Richmond
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- breast cancer
- immune response
- tumor immune microenvironment
- immunotherapy resistance
- intrinsic and extrinsic mechanisms
- immune checkpoint inhibitors
- T-cell dysfunction
- cytokines
- cancer vaccines
- tumor immunosuppression
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