Hepatocellular Carcinoma: Risk Factors, Diagnosis and Treatments
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: 15 September 2026 | Viewed by 128
Special Issue Editors
Interests: clinical and epidemiological features of chronic hepatitis C and B and its antiviral treatments; cirrhosis and complication of evolutive liver disease; natural history and treatment of hepatocellularcarcinoma; transient elastography for staging of chronic liver diseases; cardiac cirrhosis; Fontan associate liver disease
Special Issues, Collections and Topics in MDPI journals
Interests: clinical and epidemiological aspects of chronic hepatitis viral infections (HCV, HBV, HDV), high degree specialization on transient elastography staging of liver diseases in the setting of various etiologies (from viral agents to Metabolic associated steatotic liver disease, MASLD, and Fontan associated liver disease, FALD, and other rare liver vascular conditions determining liver injury)
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and represents a major global health burden. It typically develops in the setting of chronic liver disease and cirrhosis, although it can also arise in non-cirrhotic livers. HCC risk factors include chronic infection with hepatitis B, D or C virus, liver cirrhosis of any etiology, excessive alcohol consumption, the novel metabolic-associated steatotic liver disease (MASLD, and metabolic disorders such as diabetes and obesity. The diagnosis of HCC relies on a combination of clinical evaluation, imaging techniques, such as computed tomography (CT) and magnetic resonance imaging (MRI), and laboratory tests (alpha-fetoprotein, AFP). Treatment options for HCC depend on tumor stage, liver function, and the patient’s overall condition. Curative treatments include surgical resection, liver transplantation, and local ablative therapies such as radiofrequency or microwave ablation. For intermediate and advanced-stage disease, transarterial chemoembolization (TACE) and systemic therapies, including targeted agents and immune checkpoint inhibitors, have significantly improved patient outcomes. Early detection through surveillance of at-risk populations and a multidisciplinary approach to management are essential to improving survival and quality of life in patients with HCC.
Dr. Liliana Chemello
Dr. Luisa Cavalletto
Guest Editors
Manuscript Submission Information
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Keywords
- chronic hepatitis
- cirrhosis
- viral hepatitis
- HCC
- MASLD
- imaging
- TACE
- radio-ablation
- chemotherapy
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