First-Line Therapy in Thoracic Oncology

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 15 October 2025 | Viewed by 1835

Special Issue Editors


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Guest Editor
Department of Thoracic Surgery, University of Messina, Via Consolare Valeria, 1-98124 Messina, Italy
Interests: lung cancer; thoracic oncology; tracheal surgery; airway surgery; mediastinal tumors

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Guest Editor
Department of Thoracic Surgery, Sant’Andrea Hospital, Sapienza University, Via di Grottarossa 1035, 00189 Rome, Italy
Interests: brochovascular reconstruction; lung cancer; pulmonary artery
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Special Issue Information

Dear Colleagues,

Thoracic neoplasms include a heterogeneous group of diseases requiring multidisciplinary interaction for diagnosis and treatment. Lung cancer is surely the leading cause of cancer-related deaths worldwide. Over the last decades, significant advancements have been achieved in managing these tumors, especially when considering diagnostic tools for staging and restaging, integrated oncological protocols and refinements in surgical technique. Progresses in surgical approach have included minimally invasive procedures and increasing experience with more extended reconstructive operations. 

The aim of this Special Issue, “First-Line Therapy in Thoracic Oncology” will focus on some of the main diagnostic and therapeutic aspects in thoracic oncology, to highlight topics from the perspective of different specialties involved in this field. 

 We invite you to contribute with an original article or a review article dealing with a topic in the research area of Thoracic Oncology. The information of this Special Issue is listed above. Let us know if you are interested providing a title for your contribution. 

We look forward to receiving your contributions. 

Dr. Antonio D'Andrilli
Dr. Giulio Maurizi
Guest Editors

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Keywords

  • thoracic oncology
  • lung cancer
  • thymoma
  • mediastinal tumors

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Published Papers (2 papers)

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Research

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23 pages, 8092 KiB  
Article
Parenchyma-Sparing Bronchial Sleeve Resection in Low-Grade Malignant Diseases
by Ottavia Salimbene, Luca Voltolini, Olaf Mercier, Domenico Viggiano, Amir Hanna, Alessandro Gonfiotti and Elie Fadel
Cancers 2025, 17(13), 2156; https://doi.org/10.3390/cancers17132156 - 26 Jun 2025
Viewed by 245
Abstract
Background/Objectives: Sleeve and wedge bronchial resections without removal of lung tissue may represent a surgical option in selected cases of low-grade neoplasms. This study is a retrospective analysis of the surgical technique and the short- and long- term results of bronchial sleeve [...] Read more.
Background/Objectives: Sleeve and wedge bronchial resections without removal of lung tissue may represent a surgical option in selected cases of low-grade neoplasms. This study is a retrospective analysis of the surgical technique and the short- and long- term results of bronchial sleeve resections performed in the Department of Thoracic Surgery of Careggi Hospital in Florence, Italy, and in the Department of Thoracic Surgery of Marie Lannelongue Hospital in Plessis Robinson, France. Methods: Between January 2017 and October 2024, 25 patients with low-grade tumors underwent bronchial sleeve resection with total lung-sparing. We collected the preoperative data, surgical techniques, postoperative results and long-term oncologic outcomes. Results: We performed 25 bronchial sleeves which resulted in 20 typical carcinoids (TC), 3 atypical carcinoids (AT) and 2 mucoepidermoid carcinomas. Three patients had R1 resection, and one of them also had N1 disease; a multidisciplinary team opted for a “watch and wait” policy without adjuvant therapies. No local recurrences occurred, although three distant recurrences were observed. The five-year overall survival (OR) rate was 100%; the five-year disease-free survival (DFS) rate was 80%. Conclusions: Bronchoplastic procedures without lung parenchyma resection are an appropriate and feasible technique for selected cases of low-grade endobronchial neoplasms. Full article
(This article belongs to the Special Issue First-Line Therapy in Thoracic Oncology)
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Review

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15 pages, 869 KiB  
Review
Resection and Reconstruction for Lung and Airway Tumors Invading the Carina
by Camilla Vanni, Erino A. Rendina, Giulio Maurizi and Antonio D’Andrilli
Cancers 2025, 17(2), 270; https://doi.org/10.3390/cancers17020270 - 15 Jan 2025
Cited by 1 | Viewed by 1105
Abstract
Tumors located at the tracheal bifurcation constitute a heterogeneous group of neoplasms whose treatment poses significant challenges due to their anatomical location, the requirement for radical resection, the need to restore local anatomy, and the necessity of maintaining adequate oxygenation throughout the entire [...] Read more.
Tumors located at the tracheal bifurcation constitute a heterogeneous group of neoplasms whose treatment poses significant challenges due to their anatomical location, the requirement for radical resection, the need to restore local anatomy, and the necessity of maintaining adequate oxygenation throughout the entire procedure. Advances in airway reconstruction surgical techniques, anesthesia, and complementary therapies have progressively expanded indications for radical treatment of these neoplasms, resulting in significant improvements in both short- and long-term outcomes in recent years. Full article
(This article belongs to the Special Issue First-Line Therapy in Thoracic Oncology)
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