Wnt Signaling Pathway in Cancer Immunotherapy
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Immunology and Immunotherapy".
Deadline for manuscript submissions: 31 August 2026 | Viewed by 42
Special Issue Editors
Interests: leukemia; drug resistance; microenvironment; integrin; acute lymphoblastic leukemia
Special Issues, Collections and Topics in MDPI journals
Interests: Wnt signaling; somatic stem cells; differential KAT3 coactivator usage; chemical genomics; asymmetric/symmetric cell division
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The Wnt signaling pathway plays a central role in both solid tumors and hematologic malignancies by regulating key processes such as cell proliferation, survival, stemness, and metastasis. Despite extensive research into Wnt signaling in cancer biology, few therapeutic strategies targeting this pathway have been successfully translated into clinical application.
Importantly, the role of Wnt signaling in shaping the proliferation and function of immune cells remains poorly understood. As immunotherapies increasingly reshape cancer treatment paradigms, a deeper understanding of how Wnt signaling modulates the immune responses is urgently needed to overcome barriers imposed by the tumor microenvironment.
This Special Issue will address this critical knowledge gap by examining the multifaceted roles of the Wnt pathway in cancer immunotherapy. It will highlight both fundamental discoveries and emerging (pre)clinical insights that inform how targeting this complex pathway could enhance anti-tumor immunity and lead to the development of more effective, durable therapeutic strategies.
Prof. Dr. Yong-Mi Kim
Prof. Dr. Michael Kahn
Guest Editors
Manuscript Submission Information
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Keywords
- Wnt signaling
- immunotherapy
- immune cells
- macrophages
- T-cell
- CART cells
- stromal cells
- tumor microenvireonment
- cancers
- cancer stem cells
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