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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Genomic Instability in Breast Cancer: Biomarkers, Resistance and Therapeutic Opportunities
edited by Melyssa R. Bratton
submission deadline 28 Feb 2027 | Viewed by 217 | Submission Open
Keywords: genomic instability; somatic mutation; DNA damage response; homologous recombination deficiency (HRD); tumor mutational burden (TMB); chromosomal instability (CIN); tumor evolution; therapeutic resistance
Emerging Roles of HDACs in Cancer Metabolism, Plasticity and Therapeutic Response
edited by Changmin Peng
submission deadline 28 Feb 2027 | Viewed by 193 | Submission Open
Keywords: HDAC biology; cancer metabolism; therapeutic resistance; post-translational modifications; cancer plasticity
(This special issue belongs to the Section Molecular Cancer Biology)
Non-Coding RNAs in Bone Tumors: Pathogenesis, Diagnostic Biomarkers, and Therapeutic Perspectives
edited by Albert Roessner
submission deadline 28 Feb 2027 | Viewed by 190 | Submission Open
Keywords: bone tumors; non-coding RNAs; pathogenesis; biomarkers; non-coding RNA therapeutics
Artificial Intelligence in Cancers: Enhancing Diagnosis and Treatment
edited by , Adam Shephard and Shan E Ahmed Raza
submission deadline 28 Feb 2027 | Viewed by 176 | Submission Open
Keywords: artificial intelligence; machine learning; deep learning; precision oncology; cancer diagnosis; cancer screening; treatment planning; prognostic prediction; digital pathology; medical imaging; radiomics; genomics; multiomics
(This special issue belongs to the Section Cancer Informatics and Big Data)
Novel Pharmacotherapeutic Strategies for Neuroendocrine Tumors: Drug Repurposing, Combinations, and Beyond
edited by Qiyun Tang and Mujie Ye
submission deadline 28 Feb 2027 | Viewed by 169 | Submission Open
Keywords: neuroendocrine tumors; tumor metabolism; immune microenvironment; immunotherapy; targeted therapy (including PRRT); metabolic reprogramming; basic research/translational research; therapeutic resistance; biomarkers
(This special issue belongs to the Section Cancer Drug Development)
Advances in Pathology of Lymphoma and Leukemia—Second Edition
edited by
submission deadline 28 Feb 2027 | Viewed by 159 | Submission Open
Keywords: leukemia; lymphoma; immunohistochemical stains; next-generation sequencing; cytogenetics; flow cytometry analysis
(This special issue belongs to the Section Cancer Pathophysiology)
Signaling Molecules for Brain Tumors
edited by and Akshaya Murugesan
submission deadline 28 Feb 2027 | Viewed by 151 | Submission Open
Keywords: brain tumor; signaling molecules; tumor microenvironment; sensor; diagnosis and treatment; tumor microenvironment; synthesis and characterization; small drug molecules; gene expression; computational studies
(This special issue belongs to the Section Molecular Cancer Biology)
Photodiagnosis and Photodynamic Therapy for CNS Tumors
edited by
submission deadline 28 Feb 2027 | Viewed by 131 | Submission Open
Keywords: photo-diagnosis; photodynamic therapy; central nervous system tumors; photosensitizer
Quality of Life and Management of Pediatric Cancer (2nd Edition) submission deadline 28 Feb 2027 | Viewed by 131 | Submission Open
Keywords: pediatric palliative care; oncology; quality of life; early management
(This special issue belongs to the Section Pediatric Oncology)
Minimally Invasive Treatments for Prostate Cancer
edited by Javier Romero-Otero
submission deadline 28 Feb 2027 | Viewed by 124 | Submission Open
Keywords: prostate cancer; robotic surgery; focal therapy; single-port surgery; artificial intelligence
(This special issue belongs to the Section Cancer Therapy)
The Role of PSMA PET/CT in Prostate Cancer Therapy and Prognosis
edited by and Gennaro Cusato
submission deadline 28 Feb 2027 | Viewed by 106 | Submission Open
Keywords: PSMA PET/CT; prostate cancer; radioligand therapy; [177Lu]Lu-PSMA; theranostic; treatment response assessment; prognostic biomarkers; metastatic castration-resistant prostate cancer; patient selection; quantitative imaging
Emerging Therapies and Non-Pharmacologic Interventions for Lymphoma Treatment
edited by Max J. Gordon
submission deadline 28 Feb 2027 | Viewed by 94 | Submission Open
Keywords: non-hodgkin lymphoma; hodgkin lymphoma; targeted therapy; immunotherapy; epigenetic drugs; T-cell lymphoma; B-cell lymphoma; energy balance; body composition; cellular therapy
(This special issue belongs to the Section Cancer Therapy)
Chemo-Radio-Immunotherapy for Colorectal Cancer: 2nd Edition
edited by Shoichi Hazama
submission deadline 28 Feb 2027 | Viewed by 91 | Submission Open
Keywords: colorectal cancer; immunotherapy; chemotherapy; radiotherapy; combination therapy; neoadjuvant therapy; biomarkers for treatment response; anal cancer; squamous cell carcinoma; minimally invasive surgery; conversion surgery
(This special issue belongs to the Section Cancer Therapy)
Precision Diagnostics and Therapeutic Innovation in Brain Tumors
edited by
submission deadline 28 Feb 2027 | Viewed by 90 | Submission Open
Keywords: brain tumors; neuro-oncology; precision oncology; molecular diagnostics; methylation profiling; liquid biopsy; radiomics; targeted therapy; immunotherapy; clinical trials
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Tumor Microenvironment and Precision Therapeutics: From Biological Insights to Clinical Applications in Solid and Hematological Malignancies
edited by and Eleni D. Kapsali
submission deadline 28 Feb 2027 | Viewed by 80 | Submission Open
Keywords: tumor microenvironment; precision oncology; precision therapeutics; solid tumors; hematological malignancies; tumor heterogeneity; immunotherapy; targeted therapy; cellular therapy; therapeutic resistance; biomarkers; molecular profiling; single-cell sequencing; stromal cells; cancer-associated fibroblasts; extracellular matrix; extracellular vesicles; liquid biopsy; translational oncology; personalized medicine
(This special issue belongs to the Section Tumor Microenvironment)
Progress and Perspectives of Organoid Technology in Precision Oncology
edited by Leli Zeng
submission deadline 28 Feb 2027 | Viewed by 73 | Submission Open
Keywords: organoids; precision oncology; patient-derived tumor models; drug screening; tumor microenvironment; treatment resistance; multi-omics; translational cancer research
(This special issue belongs to the Section Clinical Research in Cancer)
Boron Neutron Capture Therapy (BNCT) for Solid Cancers: (1) Preclinical Innovations and Biological Mechanisms submission deadline 28 Feb 2027 | Viewed by 70 | Submission Open
Keywords: boron neutron capture therapy (BNCT); refractory cancer; targeted therapy; good patient QOL; preclinical research
(This special issue belongs to the Section Methods and Technologies Development)
Boron Neutron Capture Therapy (BNCT) for Solid Cancers: (2) Current Advances and Future Perspectives in Clinical Practice submission deadline 28 Feb 2027 | Viewed by 68 | Submission Open
Keywords: refractory cancer; boron neutron capture therapy; targeted therapy; good patient QOL; clinical practice
(This special issue belongs to the Section Methods and Technologies Development)
Toll-Like Receptors (TLRs) and Cancer Immunology: Mechanisms, Biomarkers, and Therapeutic Perspectives
edited by
submission deadline 28 Feb 2027 | Viewed by 30 | Submission Open
Keywords: toll-like receptors; innate immune sensing; cancer immunology; tumor microenvironment; immune evasion; immune checkpoints; biomarkers; cancer immunotherapy; epigenetic regulation; non-coding RNAs
Innovative Approaches in Minimally Invasive and Robotic Surgery for Gastrointestinal Oncology
edited by Maximos Frountzas, Efstathia Liatsou and Dimitrios Katsarelias
submission deadline 28 Feb 2027 | Viewed by 29 | Submission Open
Keywords: robotic surgery; minimally invasive surgery; gastrointestinal oncology; surgical innovation; oncological outcomes; fluorescence-guided surgery
(This special issue belongs to the Section Methods and Technologies Development)
Feature Papers in Section “Methods and Technologies Development” in 2026 submission deadline 1 Mar 2027 | 4 articles | Viewed by 3728 | Submission Open
Keywords: artificial intelligence (AI); medical imaging; clinical diagnostics; oncology biomarkers; precision medicine; big data integration; early cancer detection; radiomics; therapy response prediction; translational technology
(This special issue belongs to the Section Methods and Technologies Development)
New Advances and Approaches in Thyroid Cancer
edited by and José Manuel Rodríguez
submission deadline 1 Mar 2027 | 2 articles | Viewed by 3160 | Submission Open
Keywords: thyroid cancer; medullary thyroid cancer; papillary thyroid cancer; follicular thyroid cancer; poorly differentiated thyroid tumours; novel approaches; prognostic biomarkers; risk stratification
(This special issue belongs to the Section Cancer Therapy)
Novel Developments in Invasive Lobular Breast Cancer: Diagnosis, Prognosis and Therapy (2nd Edition) submission deadline 1 Mar 2027 | 1 articles | Viewed by 1480 | Submission Open
Keywords: invasive lobular carcinoma; imaging; diagnosis; pathology; tumor microenvironment; treatment; metastasis
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Advances in Endoscopic Management of Esophageal Cancer
edited by Hugo Uchima and
submission deadline 1 Mar 2027 | 1 articles | Viewed by 1045 | Submission Open
Keywords: endoscopic submucosal dissection (ESD); esophageal squamous cell carcinoma; Barrett’s esophagus
(This special issue belongs to the Section Cancer Therapy)
Precise and Personalized Radiation Therapy for Cancer Treatment
edited by Thomas Weissmann and
submission deadline 1 Mar 2027 | Viewed by 329 | Submission Open
Keywords: radiation research; artificial intelligence; cancer; adaptive radiotherapy; stereotactic radiotherapy; radiotherapy; (radio)-immunotherapy; (radio)-chemotherapy; precision radiotherapy
(This special issue belongs to the Section Cancer Therapy)
Primary and Recurrent Gynecological Cancer: Epidemiology, Management and New Therapies
edited by Nithya Ratnavelu and Ioannis Biliatis
submission deadline 5 Mar 2027 | 5 articles | Viewed by 20771 | Submission Open
Keywords: ovarian cancer; endometrial cancer; cervical cancer; vulva cancer; vaginal cancer; gynecological cancer
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Symptom Management in Cancer Care
edited by Lena Lee and Joosun Shin
submission deadline 5 Mar 2027 | Viewed by 416 | Submission Open
Keywords: symptom burden; symptom management; health service; palliative care
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Ovarian Cancer: Pathogenesis, Molecular Mechanism and Opportunities for Interventions submission deadline 10 Mar 2027 | 2 articles | Viewed by 3970 | Submission Open
Keywords: ovarian cancer; pathogenesis; therapy; biomarkers; molecular
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
The Molecular Pathogenesis of Lung Cancer: From Oncogenic Drivers to Tumor Microenvironment
edited by
submission deadline 12 Mar 2027 | Viewed by 327 | Submission Open
Keywords: lung cancer; oncogenic drivers; tumor microenvironment; immune checkpoint inhibitors; immunotherapy resistance; predictive biomarkers
(This special issue belongs to the Section Cancer Pathophysiology)
Extracellular Vesicles in Cancer: Biology, Biomarkers and Therapeutic Applications
edited by
submission deadline 12 Mar 2027 | Viewed by 60 | Submission Open
Keywords: extracellular vesicles; exosomes; biomarker; liquid biopsy; tumor microenvironment
Clinical, Immune, and Microbial Markers of Response to Systemic Therapy in Skin Cancer
edited by
submission deadline 14 Mar 2027 | 1 articles | Viewed by 895 | Submission Open
Keywords: melanoma; cutaneous squamous cell carcinoma; immunotherapy; immune checkpoint inhibitors; tumor microenvironment; microbiome; predictive biomarkers
Contemporary Management of Urologic Cancers
edited by and Hangcheng Fu
submission deadline 14 Mar 2027 | Viewed by 132 | Submission Open
Keywords: urologic oncology; prostate cancer; kidney cancer; bladder cancer; testicular cancer; penile cancer; upper urinary tract cancer; focal therapy; cancer survivorship; robotic surgery
(This special issue belongs to the Section Cancer Therapy)
Proton Therapy of Cancer Treatment
edited by Minglei Kang, Benjamin Durkee and Kuo Men
submission deadline 15 Mar 2027 | 5 articles | Viewed by 9564 | Submission Open
Keywords: proton therapy; FLASH radiotherapy; upright; pediatric cancer; head and neck cancer; affordable proton solutions; adaptive radiation therapy; treatment planning optimization; proton system commissioning
(This special issue belongs to the Section Cancer Therapy)
Advances in Bone Metastasis Research: From Mechanisms to Therapy
edited by Ye Lin
submission deadline 15 Mar 2027 | 1 articles | Viewed by 2443 | Submission Open
Keywords: bone metastasis; tumour microenvironment; biomarker; targeted therapy; detection; palliative care
(This special issue belongs to the Section Cancer Metastasis)
The Clinical, Technological, and Scientific Progress of Boron Neutron Capture Therapy
edited by
submission deadline 15 Mar 2027 | Viewed by 1521 | Submission Open
Keywords: boron neutron capture therapy (BNCT); neutron capture therapy (NCT); accelerator-based neutron source; neutron dosimetry; boron drug development; alternative capture agents; radiobiological effects; radiation oncology; interdisciplinary research; clinical translation
(This special issue belongs to the Section Cancer Therapy)
Resistance in Lung Cancer
edited by Mohamed Gadelkarim
submission deadline 15 Mar 2027 | Viewed by 633 | Submission Open
Keywords: lung cancer; SCLC; NSCLC; drug resistance; genetic mutations; tumor microenvironment; EMT; biomarkers; targeted therapy; immunotherapy
(This special issue belongs to the Section Cancer Therapy)
The Critical Intersection of Tobacco Use and Cancer Care
edited by Irene Tamí-Maury
submission deadline 15 Mar 2027 | Viewed by 412 | Submission Open
Keywords: cancer; oncology settings; smoking; tobacco use; prevention; cessation
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Robotic and Laparoscopic Techniques for Urologic Cancers: Innovations in Resection and Reconstruction
edited by
submission deadline 15 Mar 2027 | Viewed by 324 | Submission Open
Keywords: robot-assisted surgery; surgical robotics; minimally invasive surgery; artificial intelligence; complications; prognostic and predictive factors; planning; perioperative care
(This special issue belongs to the Section Methods and Technologies Development)
Clinical Update on Lung Cancer: Current Strategies and Outcome
edited by Antonio D'Andrilli
submission deadline 15 Mar 2027 | Viewed by 256 | Submission Open
Keywords: lung cancer; clinical outcomes; diagnosis; treatment
Integrative Cancer Genomics: From Classical Cytogenetics to Emerging Molecular Technologies
edited by Ying S. Zou
submission deadline 15 Mar 2027 | Viewed by 223 | Submission Open
Keywords: integrative cancer genomics; cancer cytogenetics; molecular cytogenetics; chromosomal abnormalities; optical genome mapping; next-generation sequencing; nanopore sequencing; 3D/Hi-C technologies; structural variants; AI in cytogenetics; hematological malignancies; FISH; chromosomal microarray; solid tumors
(This special issue belongs to the Section Methods and Technologies Development)
Mesothelioma Environmental Risk Factors and Epidemiological and Biological Insights
edited by Sonja Klebe
submission deadline 20 Mar 2027 | 1 articles | Viewed by 1355 | Submission Open
Keywords: mesothelioma; asbestos; mesothelial proliferation; therapy; marker
Advances in Clinical, Diagnostic and Neurosurgical Management in Pediatric Neuro-Oncology
edited by and Michael Levy
submission deadline 20 Mar 2027 | Viewed by 447 | Submission Open
Keywords: neuro-oncology; brain tumors; neuroradiology; proton therapy; pediatric; neurosurgery; treatment; chemotherapy; targeted agents; molecular subtypes; immunotherapy; late effects; radiation therapy
(This special issue belongs to the Section Pediatric Oncology)
Inflammatory Bowel Disease and Cancers: What Connections Lie Between Them?
edited by
submission deadline 20 Mar 2027 | Viewed by 194 | Submission Open
Keywords: inflammatory bowel disease; Crohn’s disease; ulcerative colitis; cancers
From Bench to Bedside: Systemic Therapy in Renal Cell Carcinoma
edited by Hailiang Zhang
submission deadline 20 Mar 2027 | Viewed by 68 | Submission Open
Keywords: renal cell carcinoma; systemic therapy; immune checkpoint inhibitors; targeted therapy; tumor microenvironment; biomarkers; precision oncology; translational research
(This special issue belongs to the Section Cancer Therapy)
Image Assisted High Precision Radiation Oncology
edited by Christopher Njeh and
submission deadline 25 Mar 2027 | 4 articles | Viewed by 4263 | Submission Open
Keywords: image-guided radiation therapy (IGRT); MR-guided radiation therapy (MRgRT); adaptive radiation therapy (ART); radiomics and AI in imaging; multi-modal imaging (CT, MRI, PET); treatment planning and verification; real-time tracking and motion management; stereotactic radiotherapy (SBRT/SRS); imaging biomarkers; dose accumulation and image registration
(This special issue belongs to the Section Methods and Technologies Development)
Feature Papers in Section “Infectious Agents and Cancer” submission deadline 25 Mar 2027 | 1 articles | Viewed by 1140 | Submission Open
Keywords: infectious agents; microbiota; biomarker; oncology; cancers
(This special issue belongs to the Section Infectious Agents and Cancer)
Imaging-Based Cancer Radiotherapy
edited by and Alberto Traverso
submission deadline 25 Mar 2027 | 1 articles | Viewed by 733 | Submission Open
Keywords: radiotherapy; imaging biomarkers; artificial intelligence; radiomics; toxicity prediction; adaptive radiotherapy; automated treatment planning; image-guided radiotherapy; multimodal learning; precision oncology
(This special issue belongs to the Section Methods and Technologies Development)
Smart Nanotechnology for Drug Delivery in Cancer Therapy
edited by
submission deadline 30 Mar 2027 | 1 articles | Viewed by 2654 | Submission Open
Keywords: nanotechnology; drug delivery; cancer therapy; nanocarriers; nanoparticles; nano-devices; nano-channels
(This special issue belongs to the Section Methods and Technologies Development)
Brachytherapy in the Treatment of Gynaecological Malignancies
edited by
submission deadline 30 Mar 2027 | 2 articles | Viewed by 1683 | Submission Open
Keywords: image-guided brachytherapy; gynecological malignancies; reirradiation using brachytherapy; cervical cancer; endometrial cancer; vulva/vagina cancer; cancer in the elderly; brachy education
(This special issue belongs to the Section Cancer Therapy)
Radiation Therapy for Meningiomas
edited by Helen A. Shih and Lia M. Halasz
submission deadline 30 Mar 2027 | 1 articles | Viewed by 830 | Submission Open
Keywords: radiation therapy; proton radiation; particle therapy; theranostics; brachytherapy; molecular features; advance imaging; late toxicities; quality of life
(This special issue belongs to the Section Cancer Therapy)
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