Toll-Like Receptors (TLRs) and Cancer Immunology: Mechanisms, Biomarkers, and Therapeutic Perspectives
A Special Issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: 28 February 2027 | Viewed by 30
Editor
Interests: cancer immunology; toll-like receptors; innate immunity; immune profiling; microRNA; tumor microenvironment; immunotherapy; immune checkpoints; inflammation-associated carcinogenesis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Toll-like receptors (TLRs) are key components of innate immune recognition mechanisms and play a complex role in cancer biology. By recognizing molecular patterns associated with pathogens and tissue damage, TLRs participate in the regulation of inflammatory signaling, immune cell activation, antigen presentation, and shaping the tumor microenvironment. Epigenetic changes, which can influence TLR expression, adaptor protein activity, and the intensity of TLR-dependent signaling pathways, are also gaining increasing importance. Mechanisms such as DNA methylation, histone modifications, chromatin remodeling, and regulation by non-coding RNAs, including microRNAs, can modulate inflammatory and antitumor responses by influencing interactions between cancer cells and immune cells. Depending on the cancer type, cellular context, and disease stage, TLR-dependent signaling pathways can exert both anti-tumor effects by enhancing immune surveillance and pro-tumor effects by promoting chronic inflammation, immune evasion, angiogenesis, metastasis, and treatment resistance.
This Special Issue welcomes original research and review articles on the role of TLRs in carcinogenesis, tumor progression, cancer-related inflammation, immune profiling, and treatment response. Particular attention will be given to TLR expression and signaling in cancer and immune cells, TLR-related biomarkers, interactions with immune checkpoints, and the therapeutic potential of TLR agonists or antagonists. Studies on the epigenetic regulation of TLR-dependent pathways, including DNA methylation, histone modifications, and non-coding RNAs, are also encouraged, especially in the context of diagnostic, prognostic, predictive, and therapeutic applications.
We invite submissions of papers on basic, translational, and clinical research that expand our understanding of TLR-dependent mechanisms and epigenetic regulation in cancer, and their diagnostic, prognostic, and therapeutic implications.
Dr. Paulina Mertowska
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- toll-like receptors
- innate immune sensing
- cancer immunology
- tumor microenvironment
- immune evasion
- immune checkpoints
- biomarkers
- cancer immunotherapy
- epigenetic regulation
- non-coding RNAs
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