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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Gastrointestinal Malignancy: Epidemiology and Risk Factors

edited by Patrick Okolo and Chengu Niu

submission deadline 31 Aug 2026 | 9 articles | Viewed by 49329

Keywords: gastrointestinal cancer; epidemiology; risk factors; molecular markers; genetic factors; therapeutic advancements; prevention strategies; public health; interdisciplinary approaches; clinical impact

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Long-Term Cancer Survivors: Rehabilitation and Quality of Life

edited by

Juan Rodríguez-Mansilla

Blanca Gonzalez-Sanchez

and

María Jiménez-Palomares

submission deadline 31 Aug 2026 | 9 articles | Viewed by 25135

Keywords: long term; cancer survivors; quality of life; rehabilitation; physical activity; cognition; non-pharmacological therapies

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advancing Horizons in Colorectal Surgery: Innovative Approaches and Outcomes

edited by Petros I. Bangeas and Vasileios N. Papadopoulos

submission deadline 31 Aug 2026 | 5 articles | Viewed by 23726

Keywords: colorectal surgery; postoperative pain; surgical site infections; anastomotic leaks; minimally invasive techniques; robotic surgery

(This special issue belongs to the Section Cancer Therapy)

Feature Review Paper Special Issue in Section Molecular Cancer Biology

edited by

Donat Kögel

submission deadline 31 Aug 2026 | 4 articles | Viewed by 15809

Keywords: molecular biology; cell biology; cancer; tumor; cancer cell

(This special issue belongs to the Section Molecular Cancer Biology)

Personalized Radiotherapy in Cancer Care (2nd Edition)

edited by

Bin S. Teh

and

Waqar M. Haque

submission deadline 31 Aug 2026 | 9 articles | Viewed by 13534

Keywords: predictive biomarkers; treatment-related toxicity; radiation treatments; radiation dose and volume; personalized radiation therapy

(This special issue belongs to the Section Methods and Technologies Development)

Cancer Stem Cells: The Origin of Tumor Relapse and Metastasis

edited by

Ming Tan

and

Evgeniy V. Denisov

submission deadline 31 Aug 2026 | 3 articles | Viewed by 8868

Keywords: metastasis; cancer stem cell; tumor microenvironment; tumor heterogeneity; plasticity; immune evasion; therapeutic resistance

(This special issue belongs to the Section Molecular Cancer Biology)

Oral Cancer: Prevention and Early Detection (2nd Edition)

edited by

Gianluca Tenore

and

Umberto Romeo

submission deadline 31 Aug 2026 | 2 articles | Viewed by 7658

Keywords: oral cancer; oral squamous cell carcinoma; alcohol and tobacco; human papillomavirus (HPV); biomarkers; biopsy and liquid biopsy; oral potentially malignant disorders (OPMDs); oral pathology and oral medicine; oral and maxillofacial surgery; radiotherapy and chemotherapy

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

New Insights into Microbial-Based Cancer Therapy

edited by Amitabha Ray

submission deadline 31 Aug 2026 | 3 articles | Viewed by 7554

Keywords: microbial therapy; cancer immunotherapy; bioengineering; immune modulation; tumor microenvironment

(This special issue belongs to the Section Cancer Therapy)

Renal Cell Carcinoma: Genetics, Surgical Management, and Systemic Therapy

edited by Alejandro Remigio Rodríguez, Stênio C. Zequi and Maxwell Sandberg

submission deadline 31 Aug 2026 | 6 articles | Viewed by 7507

Keywords: renal cell carcinoma; robotics; laparoscopy; systemic therapy; genetics; surgery; urology; disparities; tumor thrombus; cryotherapy; global health

Neoadjuvant Therapy in Hepatopancreatobiliary Malignancies: Current Trends and Future Directions

edited by

Daniela Cornelia Lazăr

submission deadline 31 Aug 2026 | 4 articles | Viewed by 6377

Keywords: neoadjuvant therapy; hepatopancreatobiliary malignancies; hepatocellular carcinoma; pancreatic cancer; cholangiocarcinoma; chemotherapy; radiotherapy; immunotherapy; targeted therapies; personalized treatment

(This special issue belongs to the Section Cancer Therapy)

Advances in the Management and Prognosis of Brain Metastases

edited by

Guixiang Liao

and

Muhammad Khan

submission deadline 31 Aug 2026 | 5 articles | Viewed by 6368

Keywords: immunotherapy; target therapy; stereotactic radiotherapy; prognosis; quality of life

(This special issue belongs to the Section Cancer Therapy)

Screening and Surveillance of Gastrointestinal and Pancreatic Cancers

edited by Darina Kohoutová and

Jan Bures

submission deadline 31 Aug 2026 | 2 articles | Viewed by 6128

Keywords: screening; surveillance; GI cancer; pancreatic precancerous lesions

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Prediction of Melanoma

edited by

Irene Stefanaki

submission deadline 31 Aug 2026 | 3 articles | Viewed by 5959

Keywords: melanoma; melanoma genetics; biomarkers; predictive tools; risk prediction; risk factors; artificial intelligence

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Therapy for HER2 Breast Cancer

edited by

Junji Tsurutani

and Sandra M. Swain

submission deadline 31 Aug 2026 | 3 articles | Viewed by 5341

Keywords: antibody–drug conjugate; trastuzumab; pertuzumab; tyrosine kinase inhibitor; trastuzumab deruxtecan

(This special issue belongs to the Section Cancer Therapy)

Advances in the Diagnosis and Treatment of Genitourinary Cancers (2nd Edition)

edited by Piotr Radziszewski and

Łukasz Zapała

submission deadline 31 Aug 2026 | 2 articles | Viewed by 4523

Keywords: genitourinary cancer; point-of-care diagnostics; personalized treatment; immunotherapy

(This special issue belongs to the Section Cancer Therapy)

AI-Enhanced Radiotherapy in Oncology: Optimization from Planning to Clinical Impact

edited by Christian Fiandra and Linda Rossi

submission deadline 31 Aug 2026 | 5 articles | Viewed by 4433

Keywords: radiotherapy; oncology; artificial intelligence (AI); image segmentation; dose prediction and monitoring; deep learning; treatment planning optimization; adaptive radiotherapy; clinical decision support; personalized cancer treatment

(This special issue belongs to the Section Methods and Technologies Development)

Transforming Liver Cancer Care: From Molecular Understanding to Novel Therapeutic Strategies

edited by

Chencheng Xie

submission deadline 31 Aug 2026 | 2 articles | Viewed by 3438

Keywords: liver cancer; molecular research; biomarkers; targeted therapy; translational research

CAR T-Cell Therapy and Multiple Myeloma

edited by Jo Caers

submission deadline 31 Aug 2026 | 3 articles | Viewed by 3256

Keywords: multiple myeloma; CAR-T immunotherapy; toxicity; efficacy; tumor models; safety

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

New Advances and Approaches in Thyroid Cancer

edited by

Beatriz Febrero

and José Manuel Rodríguez

submission deadline 31 Aug 2026 | 2 articles | Viewed by 3007

Keywords: thyroid cancer; medullary thyroid cancer; papillary thyroid cancer; follicular thyroid cancer; poorly differentiated thyroid tumours; novel approaches; prognostic biomarkers; risk stratification

(This special issue belongs to the Section Cancer Therapy)

Discovery and Development of New Anticancer Drugs and Delivery Systems: Special Emphasis on Artificial Intelligence, Machine-Learning, and Big Data Analysis

edited by

Rajeev K. Singla

Bairong Shen

and

Anupam Bishayee

submission deadline 31 Aug 2026 | 1 articles | Viewed by 3005

Keywords: artificial intelligence; machine learning; big-data analytics; natural compounds; translational oncology; drug delivery systems

(This special issue belongs to the Section Cancer Drug Development)

Insulin Resistance, Diabetes, and Cancer: An Overview of the Pathogenetic Mechanisms

edited by

Kumar Ganesan

and

Kunka Mohanram Ramkumar

submission deadline 31 Aug 2026 | 2 articles | Viewed by 2929

Keywords: insulin resistance; type 2 diabetes; hyperinsulinemia; IGF-1 signaling; tumor microenvironment; metabolic inflammation; adipokines; antidiabetic drugs; cancer metabolism; phytocompounds; bioactive molecules; hormone regulation; intracellular signalling pathways

(This special issue belongs to the Section Cancer Pathophysiology)

Roles of the Tumor Microenvironment on Liquid Biopsy (2nd Edition)

edited by

Dario Marchetti

submission deadline 31 Aug 2026 | 1 articles | Viewed by 2779

Keywords: liquid biopsy; CTCs, CTC characterization and CTC clustering; ctDNA and ctDNA profiling; exosomes/extracellular vesicles and biology; tumor microenvironment; bone marrow cellular/molecular heterogeneity; CTCs/blood/BM cells crosstalk; analytical validity, clinical validity, and clinical utility of liquid biopsy; liquid biopsy interplaying dormancy and metastasis

(This special issue belongs to the Section Tumor Microenvironment)

Diagnosis and Biomarkers for Hematologic Malignancies

edited by

Luis Colomo

and

Francesco Lanza

submission deadline 31 Aug 2026 | 2 articles | Viewed by 2654

Keywords: hematologic malignancies; diagnosis; biomarkers

(This special issue belongs to the Section Cancer Biomarkers)

Cervical Cancer: Screening and Treatment in 2026

edited by

Benedetta Guani

and

Fabrice Lécuru

submission deadline 31 Aug 2026 | 2 articles | Viewed by 2517

Keywords: cervical cancer; fertility sparing; screening; early stage cervical cancer; locally advanced cervical cancer; sentinel lymph node; staging lymphadenectomy; trachelectomy; immunotherapy in cervical cancer; target therapy in cervical cancer

Hypoxia-Targeting Strategies to Improve Cancer Therapy Outcomes

edited by Roben Gieling and Ayse Latif

submission deadline 31 Aug 2026 | 1 articles | Viewed by 2137

Keywords: tumor hypoxia; cancer therapy resistance; hypoxia-targeted therapy; hypoxia-inducible factors (HIFs); hypoxia-activated prodrugs; oxygen-modifying agents; combination therapy; precision drug delivery; tumor microenvironment; translational cancer research

(This special issue belongs to the Section Cancer Therapy)

From Molecular Genomics and the Tumor Microenvironment to Precision Diagnosis and Therapy in Liver Cancer

edited by

Daniel Wai Hung Ho

and Yuman Tsui

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1900

Keywords: tumor heterogeneity; cancer genomics; sequencing; molecular landscapes; tumor microenvironment; cancer stem cell; liquid biopsy; diagnostics; biomarker; treatment and resistance

Clinical and Research Progress in the Resection of Gastro-Esophageal Cancer (2nd Edition)

edited by Biniam Kidane

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1586

Keywords: gastro-esophageal cancer resection; multi-modal management; surgical morbidity and mortality; treatment-related toxicities; perioperative outcomes

(This special issue belongs to the Section Clinical Research in Cancer)

The Unseen Burden: Incidence and Outcomes of Infections in Leukemia

edited by

Elisa Buzzatti

and

Maria Ilaria Del Principe

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1163

Keywords: infection management; infectious risk; antimicrobial therapy; antimicrobial prophylaxis

(This special issue belongs to the Section Infectious Agents and Cancer)

Emergencies in Gastrointestinal Surgical Oncology

edited by

Fausto Rosa

Carlo Alberto Schena

and

Nicola De'Angelis

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1129

Keywords: surgical oncology; emergencies; emergency surgery; acute care surgery; palliation; futility in surgery

(This special issue belongs to the Section Clinical Research in Cancer)

Heat Shock Proteins in Metastatic Cancer: From Molecular Mechanisms to Clinical Targeting

edited by Daniel Jay and

Pragya Singh

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1066

Keywords: HSPs and eHSPs (Hsp90, Hsp70, Hsp60, Hsp40 and Hsp27); HSF1; chaperone; cancer metastasis; EMT; tumor microenvironment; ECM remodelling; anoikis resistance; circulating tumor cell survival; premetastatic niche; metastatic colonisation; extracellular vesicles; exosomes; cancer stem cells; therapy resistance; metastatic biomarkers; immunotherapy; HSP-targeted therapy

Cutaneous T-Cell Lymphomas in Special Populations

edited by

Stefan K. Barta

and Caroline Myers

submission deadline 31 Aug 2026 | 1 articles | Viewed by 522

Keywords: cutaneous T-cell lymphoma; adult T-cell leukemia/lymphoma; lymphoproliferative disorder; hematopoietic stem cell transplant; secondary malignancy; pediatric lymphoma; skin of color; health care disparities; translational research

Hereditary Cancer: State of the Art

edited by Joanne Ngeow, Jianbang Chiang and

Rashid N. Lui

submission deadline 31 Aug 2026 | Viewed by 490

Keywords: hereditary cancer syndromes; inherited cancers; cancer genetics and genomics; germline variants; surveillance

(This special issue belongs to the Section Cancer Pathophysiology)

Clinical Application of Proton Pencil Beam Scanning Radiotherapy in Cancer

edited by Pavel Vítek

submission deadline 31 Aug 2026 | Viewed by 401

Keywords: proton radiotherapy; pencil beam scanning; randomized trial; dosimetry; plan robustness; LET—linear energy transfer; RBE—radiobiologic equivalence; lymphocyte; immunologic reaction

(This special issue belongs to the Section Clinical Research in Cancer)

Clinical Trials for T-Cell Lymphoma

edited by Jasmine M. Zain

submission deadline 31 Aug 2026 | Viewed by 352

Keywords: peripheral T cell lymphoma; EZH2 inhibitors; JAK STAT pathways; tumor microenvironment; immunotherapy

(This special issue belongs to the Section Clinical Research in Cancer)

Human Carcinogens—Chemical Agents, Occupational Exposure and Health Impact

edited by Jun-Pyo Myong

submission deadline 31 Aug 2026 | Viewed by 330

Keywords: occupational exposure; chemical carcinogens; risk assessment; epidemiology; biomarkers; exposure assessment; preventive strategies; workplace safety; occupational health; regulatory measures

(This special issue belongs to the Section Infectious Agents and Cancer)

Advances in the Early Diagnosis and Treatment of Gastric Cancer (2nd Edition)

edited by Sharona B. Ross

submission deadline 31 Aug 2026 | Viewed by 328

Keywords: gastric cancer; tumor resection; liver tumors

(This special issue belongs to the Section Cancer Therapy)

Cancer Survivorship: Transforming Challenges into Quality Living

edited by

Christine Maheu

and Tania Estapé

submission deadline 31 Aug 2026 | Viewed by 290

Keywords: cancer survivorship; psychological adjustment; emotional well-being; coping; quality of life; family relationships; couple functioning; sexuality; return to work; psychosocial interventions; financial toxicity

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

The Invasion and Metastasis in Skin Cancer

edited by Emanuela Passoni,

Nerina Denaro

and

Gianluca Nazzaro

submission deadline 31 Aug 2026 | Viewed by 289

Keywords: melanoma; skin cancer; basal cell carcinoma; squamous cell carcinoma; Kaposi’s sarcoma; dermoscopy; photoprotection; skin cancer prevention

The Role of Artificial Intelligence in Detection and Treatment of Head and Neck Cancer

edited by

Sophia Z. Shalhout

submission deadline 31 Aug 2026 | Viewed by 283

Keywords: artificial intelligence; machine learning; deep learning; large language models; multimodal integration; computer vision; pathomics; image-derived biomarkers

(This special issue belongs to the Section Methods and Technologies Development)

Wnt Signaling Pathway in Cancer Immunotherapy

edited by

Yong-Mi Kim

and

Michael Kahn

submission deadline 31 Aug 2026 | Viewed by 281

Keywords: Wnt signaling; immunotherapy; immune cells; macrophages; T-cell; CART cells; stromal cells; tumor microenvireonment; cancers; cancer stem cells

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Paradigm Shifts in Gynaecological Oncology Surgery (2nd Edition)

edited by

Faiza Gaba

submission deadline 31 Aug 2026 | Viewed by 261

Keywords: gynecological surgery; genomic risk management; survivorship health economics

(This special issue belongs to the Section Cancer Therapy)

Progress in Minimally Invasive Approaches in Gastrointestinal Cancer

edited by Florin Grama and

Andrei Chitul

submission deadline 31 Aug 2026 | Viewed by 260

Keywords: minimally invasive surgery; gastrointestinal cancer; endoscopic techniques; hybrid techniques

(This special issue belongs to the Section Methods and Technologies Development)

Artificial Intelligence in Gastrointestinal Cancer Diagnosis and Treatment

edited by Eun Jeong Gong

submission deadline 31 Aug 2026 | Viewed by 257

Keywords: artificial intelligence; gastrointestinal cancer; deep learning; precision oncology; clinical decision support; large language model; explainable artificial intelligence

(This special issue belongs to the Section Methods and Technologies Development)

Pancreatic Cancer: Clinical Trials, Treatment Strategies, and Future Directions

edited by Brent Taiting Xia

submission deadline 31 Aug 2026 | Viewed by 255

Keywords: pancreatic cancer; neoadjuvant therapy; clinical trials; pancreatectomy; chemoradiation

(This special issue belongs to the Section Clinical Research in Cancer)

Palliative and Supportive Care in Oncology

edited by

Carmen Roch

and Heidrun Golla

submission deadline 31 Aug 2026 | Viewed by 255

Keywords: screening; timely palliative care; caregivers; symptom control; digitalization; care structures; gender-specific aspects

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advances in Drug Delivery for Cancer Therapy (2nd Edition)

edited by

Ashakumary Lakshmikuttyamma

submission deadline 31 Aug 2026 | Viewed by 250

Keywords: cancer; oncology; therapeutic target; drug resistance; immunotherapy; chemotherapy; small molecule inhibitors; drug delivery; nanoparticle

(This special issue belongs to the Section Cancer Drug Development)

Head and Neck Cancer Surgery: Resection and Reconstruction

edited by

Takenori Ogawa

, Kiyoto Shiga and Hisakazu Kato

submission deadline 31 Aug 2026 | Viewed by 239

Keywords: head and neck cancer surgery; tumor resection; reconstructive surgery; microvascular free flap; functional reconstruction; oncologic outcomes; perioperative management; rehabilitation (speech and swallowing); imaging and surgical planning; multidisciplinary care

(This special issue belongs to the Section Methods and Technologies Development)

Emerging Therapies in the Management of Gastrointestinal Malignancies (3rd Edition)

edited by

Amir A. Rahnemai Azar

submission deadline 31 Aug 2026 | Viewed by 238

Keywords: hepatocellular carcinoma; colorectal cancer; esophageal cancer; immunotherapy; targeted therapy

(This special issue belongs to the Section Cancer Therapy)

Diagnosis and Novel Therapies for Pediatric Solid Tumor

edited by

Alberto Pappo

and