Cancer Stem Cells: The Origin of Tumor Relapse and Metastasis
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: 31 August 2026 | Viewed by 831
Special Issue Editors
Interests: cancer stem cells; cancer metabolism; cell stress-responsive signaling
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In the ever-evolving field of cancer research, unraveling the intricate dynamics of cancer stem cells and their interplay with the tumor microenvironment is critical—particularly in the context of metastasis, the most devastating hallmark of cancer progression. We are pleased to invite esteemed cancer researchers and physicians to contribute their expertise and insights to our upcoming collection of manuscripts, titled "Cancer Stem Cells: The Origin of Tumor Relapse and Metastasis".
The themes of this Special Issue are of paramount importance, as cancer stem cells not only drive tumor initiation and therapy resistance but also play a fundamental role in metastatic dissemination. Their unique ability to self-renew and adapt to microenvironmental cues fuels tumor heterogeneity and enables the invasion of distant organs. Furthermore, the tumor microenvironment—comprising stromal support, immune modulation, and extracellular matrix remodeling—creates a permissive niche that fosters metastatic outgrowth. Understanding these complex interactions is key to developing targeted strategies that can disrupt the metastatic cascade and improve patient outcomes.
We invite submissions in the form of both original research and comprehensive review articles covering a wide range of topics, including (but not limited to) tumor biology, metastasis, cancer stem cell signaling, tumor heterogeneity, plasticity, immune evasion, and therapeutic resistance. By sharing your cutting-edge discoveries, you can help shape the future of cancer treatment and bridge the gap between bench and bedside.
Dr. Ming Tan
Dr. Evgeniy V. Denisov
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- metastasis
- cancer stem cell
- tumor microenvironment
- tumor heterogeneity
- plasticity
- immune evasion
- therapeutic resistance
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