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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Radiation Therapy for Modern Management of Bone Metastases (2nd Edition)

edited by

Francesco Cellini

submission deadline 25 Feb 2026 | Viewed by 78 | Submission Open

Keywords: radiotherapy; palliative care; steretactic radiotherapy; SBRT; immunotherapy; chemotherapy; oligometastases

(This special issue belongs to the Section Cancer Therapy)

Minimal Residual Disease in Solid Tumors: Emerging Technologies and Clinical Applications

edited by

Sofia Agelaki

Kleita Michaelidou

and Aristeidis Boukouris

submission deadline 25 Feb 2026 | Viewed by 52 | Submission Open

Keywords: minimal residual disease (MRD); solid tumors; circulating tumor DNA (ctDNA); liquid biopsy; tumor-informed assays; precision oncology

(This special issue belongs to the Section Cancer Biomarkers)

Harnessing the Gut Microbiome to Improve Colorectal Cancer Outcomes

edited by Carole S. Richard

submission deadline 25 Feb 2026 | Viewed by 39 | Submission Open

Keywords: colorectal cancer (CRC); gut microbiome; screening; CRC cells; the gut microenvironment; oncological outcomes

(This special issue belongs to the Section Infectious Agents and Cancer)

Advances in the Treatment of Gastrointestinal (GI) Cancers

edited by

Yoshiyasu Kono

submission deadline 27 Feb 2026 | Viewed by 52 | Submission Open

Keywords: gastrointestinal cancers; targeted therapy; immunotherapy; precision oncology; biomarkers; molecular mechanisms; tumor microenvironment; resistance to therapy; translational research; clinical trials

(This special issue belongs to the Section Cancer Therapy)

Clinical and Translational Updates in Renal Cell Carcinoma (2nd Edition)

edited by

Irbaz B Riaz

submission deadline 27 Feb 2026 | Viewed by 47 | Submission Open

Keywords: renal cell carcinoma; RCC; machine cearning; clinical; translational developments

(This special issue belongs to the Section Clinical Research of Cancer)

Application of Imaging in Breast Cancer

edited by

Yun-Chung Cheung

Yao Melissa Min-Szu

and Chung Wai-Shan

submission deadline 28 Feb 2026 | 6 articles | Viewed by 12209 | Submission Open

Keywords: breast cancer; mammography/tomosynthesis/contrast-enhanced mammography; sonography/contrast-enhanced sonography; magnetic resonance imaging; PET/CT; quantitative imaging; elastography; optical imaging; artificial intelligence; image-guided biopsy

(This special issue belongs to the Section Methods and Technologies Development)

Improving Surgical Care for Patients with Hepatobiliary and Pancreatic Cancers

edited by Christopher B. Nahm and Kai M. Brown

submission deadline 28 Feb 2026 | 2 articles | Viewed by 5963 | Submission Open

Keywords: hepatobiliary; pancreatic; surgery; biomarkers; prognosis; treatment strategy

(This special issue belongs to the Section Cancer Therapy)

Advances in Bladder Preservation Approaches for Bladder Cancer (2nd Edition)

edited by

Jay J. Liao

and Todd A. Yezefski

submission deadline 28 Feb 2026 | 3 articles | Viewed by 5863 | Submission Open

Keywords: bladder cancer; bladder preservation; trimodality therapy; chemoradiation; immunotherapy; intravesical therapy; BCG refractory or unresponsive

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Advances in Oncological Imaging (2nd Edition)

edited by

Michaela Cellina

and

Maurizio Cè

submission deadline 28 Feb 2026 | 2 articles | Viewed by 3461 | Submission Open

Keywords: oncological imaging; radiomics; deep learning; machine learning; image reconstruction; artificial intelligence; outcome prediction; oncological treatment planning; advanced imaging; personalized medicine

(This special issue belongs to the Section Methods and Technologies Development)

Navigating the Landscape of Female Cancers: Recent Discoveries and Treatment Trends

edited by

Federica Martorana

and Giacomo Barchiesi

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2004 | Submission Open

Keywords: female malignancies; breast cancer; gynecological cancer; ovarian cancer; endometrial cancer; cervical cancer

(This special issue belongs to the Section Cancer Therapy)

Heterogeneity in Intra-Cranial Tumors: Diagnostic, Prognostic, and Therapeutic Implications

edited by

Francois Ducray

, Shawn L. Hervey-Jumper and Thiebaud Picart

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1428 | Submission Open

Keywords: glioma; histo-molecular classification; intra-tumoral heterogeneity; inter-tumoral heterogeneity; meningioma; neuro-oncology; neurosurgery

(This special issue belongs to the Section Cancer Metastasis)

Cell Therapy in Hematological Malignancies

edited by

Francesco Gaudio

and

Stefano Martinotti

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1347 | Submission Open

Keywords: cell therapy; immunotherapy; target therapy; hematological malignancies; tumor immunology

(This special issue belongs to the Section Cancer Therapy)

Innovative and Personalized Approaches to Improve Patient Outcomes in Gynecological Oncology

edited by Anke Smits and James Dilley

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1341 | Submission Open

Keywords: gynecological cancer; lifestyle; prehabilitation; rehabilitation; survival; quality of life

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

New Insights into General, Functional and Oncologic Urology

edited by Kajetan Juszczak and

Przemysław Adamczyk

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1214 | Submission Open

Keywords: basic science; experimental models; urological cancer; management innovations; multidisciplinary approaches; treatment outcomes

(This special issue belongs to the Section Clinical Research of Cancer)

Advancements in Technologies for Radiation Biology, Oncology, and Protection

edited by

Zhixiang Wang

and

Yi Wang

submission deadline 28 Feb 2026 | 1 articles | Viewed by 853 | Submission Open

Keywords: radiation biology; oncology; radiation protection; carcinogenesis; multi-omics; radiomics; radiotherapy; biodosimetry; adverse outcome pathway (AOP); personalized medicine

(This special issue belongs to the Section Cancer Informatics and Big Data)

Diagnosis, Staging, and Management for Gynecologic Oncology

edited by

Malgorzata Klimek

submission deadline 28 Feb 2026 | 1 articles | Viewed by 761 | Submission Open

Keywords: gynecologic oncology; cancer biology; HPV infection; molecular risk factors; translational medicine; cancer staging systems; radiation therapy; brachytherapy; radioresistance

(This special issue belongs to the Section Cancer Therapy)

Immunoediting in Cancer Therapies

edited by Vijay Kumar

submission deadline 28 Feb 2026 | 1 articles | Viewed by 708 | Submission Open

Keywords: cancer; cancer immunology; immunosurveillance; immunoediting; immunotherapy; immunomodulation; immunometabolism

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Personalized Radiotherapy in Cancer Care (2nd Edition)

edited by

Bin S. Teh

and

Waqar M. Haque

submission deadline 28 Feb 2026 | 1 articles | Viewed by 638 | Submission Open

Keywords: predictive biomarkers; treatment-related toxicity; radiation treatments; radiation dose and volume; personalized radiation therapy

(This special issue belongs to the Section Methods and Technologies Development)

Predictive and Prognostic Biomarkers for Response to Neoadjuvant Chemotherapy for Breast Cancer

edited by Tarek M. A. Abdel-Fatah

submission deadline 28 Feb 2026 | 1 articles | Viewed by 520 | Submission Open

Keywords: breast cancer; predictive and prognostic biomarkers; neoadjuvant chemotherapy; HER2-targeting agents; complete pathological response

(This special issue belongs to the Section Cancer Therapy)

MRI and Artificial Intelligence in Oncology: Current Research and Future Directions

edited by

Amita Shukla-Dave

and

Ramesh Paudyal

submission deadline 28 Feb 2026 | 1 articles | Viewed by 501 | Submission Open

Keywords: MRI; AI; radiology; oncology; clinical trials

(This special issue belongs to the Section Methods and Technologies Development)

Perioperative Care in Gynecologic Oncology: 2nd Edition

edited by Nikolaos Thomakos and

Vasilios Pergialiotis

submission deadline 28 Feb 2026 | 1 articles | Viewed by 499 | Submission Open

Keywords: enhanced recovery; ERAS; immunonutrition; prehabilitation; gynecologic oncology; minimally invasive surgery

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advances in the Diagnosis and Treatment of Genitourinary Cancers (2nd Edition)

edited by Piotr Radziszewski and

Łukasz Zapała

submission deadline 28 Feb 2026 | 1 articles | Viewed by 494 | Submission Open

Keywords: genitourinary cancer; point-of-care diagnostics; personalized treatment; immunotherapy

(This special issue belongs to the Section Cancer Therapy)

Precision Health Care and Interventions in Hereditary Breast and Ovarian Cancer and Lynch Syndrome (2nd Edition)

edited by

Maria C. Katapodi

submission deadline 28 Feb 2026 | Viewed by 483 | Submission Open

Keywords: breast cancer; ovarian Cancer; lynch Syndrome; precision healthcare

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

MYC Oncogene in Cancer: Cancer Cell Intrinsic and Immune Inhibitory Functions

edited by Wadie Mahauad Fernandez and Konstantinos V. Floros

submission deadline 28 Feb 2026 | Viewed by 147 | Submission Open

Keywords: MYC oncogene; molecular oncology; immuno-oncology; tumor microenvironment

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in Choroidal Melanoma: From Treatment to Prognosis

edited by

Giovanni Paolino

submission deadline 28 Feb 2026 | Viewed by 147 | Submission Open

Keywords: melanoma; uveal; choroid; treatments; target; immunotherapy; genetics

(This special issue belongs to the Section Molecular Cancer Biology)

Image-Assisted High-Precision Radiation Oncology

edited by He C. Wang

submission deadline 28 Feb 2026 | Viewed by 126 | Submission Open

Keywords: medical imaging; radiation oncology; artificial intelligence; radiomics; adaptation; tumor response

(This special issue belongs to the Section Cancer Therapy)

Novel Approaches to Machine Learning and Artificial Intelligence in Cancer Research and Care (2nd Edition)

edited by

Caroline Chung

and Chris J. Gibbons

submission deadline 28 Feb 2026 | Viewed by 121 | Submission Open

Keywords: machine learning; deep learning; artificial intelligence; interpretable AI; data quality; metadata; data quality; cancer; MLOps; data science; real-world data

(This special issue belongs to the Section Cancer Informatics and Big Data)

Childhood Acute Lymphoblastic Leukemia

edited by Noriko Satake

submission deadline 28 Feb 2026 | Viewed by 120 | Submission Open

Keywords: childhood acute lymphoblastic leukemia; diagnosis; novel agents; targeted therapy; personalized medicine

(This special issue belongs to the Section Pediatric Oncology)

Risk of Skin Cancer: Non-Melanoma/Melanoma

edited by

Eggert Stockfleth

submission deadline 28 Feb 2026 | Viewed by 107 | Submission Open

Keywords: melanoma; non-melanoma skin cancer; keratinocyte cancer; Merkel cell carcinoma; UV exposure; immunosuppression; skin cancer prevention

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

State-of-the-Art Research on Multiple Myeloma Progression: 2nd Edition

edited by

Shebli Atrash

submission deadline 28 Feb 2026 | Viewed by 80 | Submission Open

Keywords: multiple myeloma; novel targets; novel therapies; molecular therapy; immunotherapy

(This special issue belongs to the Section Cancer Therapy)

Advances in Radiotherapy for Gynecological Cancers

edited by Roxolyana Abdah-Bortnyak

submission deadline 28 Feb 2026 | Viewed by 80 | Submission Open

Keywords: gynecological cancer; radiotherapy; brachytherapy; IMRT; SBRT; adaptive radiotherapy; treatment planning; radiomics; toxicity management; quality of life; personalized medicine

(This special issue belongs to the Section Cancer Therapy)

Mitochondria and Cancer: From Hidden Culprits to Healing Targets

edited by

Nicola Amodio

and

Marianna Scrima

submission deadline 28 Feb 2026 | Viewed by 77 | Submission Open

Keywords: mitochondria; mitochondrial dynamics; cancer-associated mitochondrial defects; mitochondrial metabolism

(This special issue belongs to the Section Cancer Pathophysiology)

Clinical Research and Prognosis of HER2-Positive Breast Cancer

edited by

Pierfranco Conte

submission deadline 28 Feb 2026 | Viewed by 71 | Submission Open

Keywords: HER2-positive breast cancer; targeted therapy; anti-HER2 therapy; long-term impacts; prognostic

(This special issue belongs to the Section Clinical Research of Cancer)

Chronic Lymphocytic Leukemia: From Genetics to Therapy

edited by

Javier Loscertales-Pueyo

submission deadline 28 Feb 2026 | Viewed by 60 | Submission Open

Keywords: chronic lymphocytic; leukemia treatment; biology

(This special issue belongs to the Section Cancer Therapy)

The Genetics of Head and Neck Squamous Cell Carcinoma

edited by

Sabrina Daniela da Silva

submission deadline 28 Feb 2026 | Viewed by 56 | Submission Open

Keywords: head and neck squamous cell carcinoma; tumor genetics; genomic profiling; precision oncology; biomarkers; tumor microenvironment; epigenetics; somatic mutations; molecular pathways; targeted therapies

(This special issue belongs to the Section Molecular Cancer Biology)

Drug Resistance Mechanisms and Tumor Microenvironment in Upper Gastrointestinal Cancers

edited by

Zheng Chen

and Heng Lu

submission deadline 28 Feb 2026 | Viewed by 56 | Submission Open

Keywords: drug resistance; tumor microenvironment; gastric cancer; esophageal cancer; immunotherapy; targeted therapy; biomarkers; precision medicine

(This special issue belongs to the Section Tumor Microenvironment)

Epigenetic and Chromatin Alterations in Hematologic Malignancies

edited by Mineko Terao and

Enrico Garattini

submission deadline 28 Feb 2026 | Viewed by 56 | Submission Open

Keywords: myelodysplastic syndrome; acute myeloid leukemia; epigenetics; chromatin alterations; leukemogenesis

(This special issue belongs to the Section Cancer Pathophysiology)

Clinical Application of Proton Pencil Beam Scanning Radiotherapy in Cancer

edited by Pavel Vítek

submission deadline 28 Feb 2026 | Viewed by 52 | Submission Open

Keywords: proton radiotherapy; pencil beam scanning; randomized trial; dosimetry; plan robustness; LET— linear energy transfer; RBE— radiobiologic equivalence; lymphocyte; immunologic reaction

(This special issue belongs to the Section Clinical Research of Cancer)

Novel Drugs for Treating Gynecologic Cancers: 2nd Edition

edited by

Tadahiro Shoji

and

Hiroaki Itamochi

submission deadline 28 Feb 2026 | Viewed by 49 | Submission Open

Keywords: gynecological cancers; novel treatment strategies; cytotoxic chemotherapeutic agents; molecularly targeted agents; immune-checkpoint inhibitors

(This special issue belongs to the Section Cancer Drug Development)

Evolution of Cancer Therapies: Access of Developing Countries to Modern Oncology

edited by

Salem Chouaib

submission deadline 28 Feb 2026 | Viewed by 46 | Submission Open

Keywords: conventional cancer therapies; modern oncology; recission medicine; cancer immunotherapy; artificial intelligence; targeted agents; equity and globally equal access

(This special issue belongs to the Section Cancer Therapy)

Neoadjuvant Immunotherapy in Genitourinary Tumors (2nd Edition)

edited by

Antonio Tufano

, Nadia Cordua and

Antonio Giordano

submission deadline 28 Feb 2026 | Viewed by 41 | Submission Open

Keywords: immunotherapy; immune checkpoint inhibitor; bladder cancer; urothelial cancer; kidney cancer; renal cell carcinoma; prostate cancer; testicular cancer; penile cancer; adrenocortical carcinoma

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Lung Cancer—Advances in Therapy and Prognostic Prediction

edited by Chinmay T. Jani and Estela Rodriguez

submission deadline 28 Feb 2026 | Viewed by 17 | Submission Open

Keywords: lung cancer; biomarkers; targeted therapies; immunotherapy; precision medicine

(This special issue belongs to the Section Cancer Biomarkers)

The Role of Regucalcin in Cancer

edited by

Masayoshi Yamaguchi

submission deadline 1 Mar 2026 | 2 articles | Viewed by 2484 | Submission Open

Keywords: cancer suppressor protein; cell signaling; metabolic regulation; transcription factor; cell proliferation; cell death; drug development; cancer therapy

(This special issue belongs to the Section Tumor Microenvironment)

Lynch Syndrome (HNPCC): Symptoms, Causes, and Outlooks

edited by

Francesca Duraturo

submission deadline 1 Mar 2026 | Viewed by 502 | Submission Open

Keywords: Lynch syndrome; genotype– phenotype correlation; highly immunogenic frame-shift neo-peptides; immunotherapy; mismatch repair genes; unclassified genetic variants; new role of MMR proteins; miRNAs; functional assay MMR deficiency

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Brain and Spinal Cord Tumors: Symptoms, Diagnosis and Treatment—2nd Edition

edited by

Alberto Feletti

and

Takashi Sugawara

submission deadline 1 Mar 2026 | Viewed by 65 | Submission Open

Keywords: brain; spinal cord; primary tumors; metastases; imaging; neuro-oncology

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Castration-Resistant Prostate Cancer: Progress and Promise: 2nd Edition

edited by

Shiv Verma

Vaibhav Singh

and

Man Mohan

submission deadline 1 Mar 2026 | Viewed by 41 | Submission Open

Keywords: castrate-resistant prostate cancer (CRPC); prostate cancer; treatment; a new therapy; drug-resistant; marker genes; bone metastasis; androgen receptor (AR); enzalutamid; e abiraterone acetate; Docetaxel

(This special issue belongs to the Section Cancer Therapy)

Prognostic and Predictive Markers in Gynecological Cancers

edited by Anna Plotkin

submission deadline 1 Mar 2026 | Viewed by 17 | Submission Open

Keywords: biomarker; gynecological cancer; management; prognostic marker; predictive marker; personalized medicine

(This special issue belongs to the Section Cancer Biomarkers)

Fertility Preservation and Hormonal Health in Oncology

edited by

Amelia Barcellini

and