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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Radiotherapy for the Management of Brain Metastases

edited by Alla Gabriella Wernicke

submission deadline 28 Feb 2027 | 2 articles | Viewed by 7155 | Submission Open

Keywords: brain metastases; molecular profiles; imaging advancements; systemic treatment options; radiotherapeutic techniques; primary irradiation; re-irradiation; cutting-edge clinical research

(This special issue belongs to the Section Cancer Metastasis)

Modern Neurosurgical Management of Gliomas

edited by

Arthur Wagner

and

Chiara Negwer

submission deadline 28 Feb 2027 | 4 articles | Viewed by 6910 | Submission Open

Keywords: precision medicine; personalized oncological surgery; intraoperative imaging; fluorescence-guided surgery; intraoperative histopathology; liquid biopsy; minimally invasive oncological surgery; radiosurgery

(This special issue belongs to the Section Cancer Therapy)

Fertility Preservation in Gynecological Cancer

edited by

Giuseppe Gullo

and

Luigi Della Corte

submission deadline 28 Feb 2027 | 3 articles | Viewed by 6606 | Submission Open

Keywords: gynecological cancer; fertility preservation; surgery treatments; fertility sparing; psychological implication

(This special issue belongs to the Section Methods and Technologies Development)

Novel Diagnostic and Therapeutic Approaches in Urologic Oncology

edited by

Whi-An Kwon

submission deadline 28 Feb 2027 | 1 articles | Viewed by 5859 | Submission Open

Keywords: urologic oncology; liquid biopsy; immunotherapy; artificial intelligence; targeted therapy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Neoantigen Vaccines for Cancer Therapy

edited by Takashi Morisaki

submission deadline 28 Feb 2027 | 3 articles | Viewed by 5029 | Submission Open

Keywords: neoantigens; vaccine; dendritic cells; cancer; immunotherapy; priming; CTL; helper T cells

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Long-Term Health Outcomes and Quality of Life in Survivors of Childhood Cancer

edited by

Esteban Orenes-Piñero

submission deadline 28 Feb 2027 | 2 articles | Viewed by 4002 | Submission Open

Keywords: acute lymphoblastic leukemia; brain tumors; childhood cancer survivors; pollutants; environment; quality of life; nutrition; chemotherapy; air and water purification

(This special issue belongs to the Section Pediatric Oncology)

Tumor Microenvironment in Cancer Therapies: Supportive or Hostile?

edited by

Constantin N. Baxevanis

submission deadline 28 Feb 2027 | 1 articles | Viewed by 3439 | Submission Open

Keywords: tumor microenvironment; protumor effects; antitumor effects; immune cells; stromal cells; extracellular matrix; cancer therapies

(This special issue belongs to the Section Tumor Microenvironment)

Integrating Chemotherapy and Immunotherapy for Head and Neck Cancer

edited by Ken Saijo

submission deadline 28 Feb 2027 | 1 articles | Viewed by 3220 | Submission Open

Keywords: head and neck squamous cell carcinomas; HNSCC; immune checkpoint inhibitor; biomarker; chemotherapy

(This special issue belongs to the Section Cancer Metastasis)

Surgery for Lung Cancer: Robot-Assisted Versus Video-Assisted Thoracoscopic Surgery and Open Thoracotomy

edited by

Mariusz Chabowski

submission deadline 28 Feb 2027 | 3 articles | Viewed by 3027 | Submission Open

Keywords: laparoscopic thoracic surgery; open thoracotomy; robotic thoracic surgery (RTS); lung cancer; surgical treatment; minimally invasive intervention

(This special issue belongs to the Section Cancer Therapy)

Transformative Genomic Technologies Shaping the Future of Precision Approaches for Haematological Malignancies

edited by

Chung Hoow Kok

and

Barbara McClure

submission deadline 28 Feb 2027 | 1 articles | Viewed by 2529 | Submission Open

Keywords: multi-omics; risk stratification; bioinformatics; AI/machine learning; hematological malignancies; biomarkers; targeted therapeutics; genomics; cancer cell biology

Advanced Segmentation in Multimodal Nuclear Imaging of Solid Tumors and Lymphomas: Tools, Challenges, and Clinical Integration

edited by

Ken Kudura

and Robert Förster

submission deadline 28 Feb 2027 | 2 articles | Viewed by 2527 | Submission Open

Keywords: multimodal nuclear imaging; artificial intelligence in nuclear medicine; radiomics in nuclear medicine; tumor segmentation; segmentation techniques; segmentation tools; outcome prediction; radioligand therapy

(This special issue belongs to the Section Methods and Technologies Development)

Oncological Healthcare: Emergency and Supportive/Palliative Approaches

edited by Ahmed Elsayem and Pavitra Parimala Krishnamani

submission deadline 28 Feb 2027 | 2 articles | Viewed by 2471 | Submission Open

Keywords: supportive oncology; palliative care; symptom distress; emergency medicine; critical care; goals of care

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Minimally Invasive and Innovative Approaches in Breast Cancer Surgery: Techniques and Outcomes

edited by

Vasileios C. Kalles

and

Ioannis K. Papapanagiotou

submission deadline 28 Feb 2027 | 3 articles | Viewed by 2375 | Submission Open

Keywords: minimally invasive breast surgery; endoscopic mastectomy; robotic mastectomy; targeted axillary dissection; breast-conserving surgery; breast reconstruction; cryoablation; surgical outcomes; patient-reported outcomes; quality of life

(This special issue belongs to the Section Clinical Research in Cancer)

Decoding the Tumor Microenvironment: Immune Cell–Tumor Interplay in Breast Cancer

edited by Abirami Sivapiragasam and Roberto A. Leon Ferre

submission deadline 28 Feb 2027 | 1 articles | Viewed by 2153 | Submission Open

Keywords: tumor microenvironment; breast cancer; immune cell–tumor interaction; immunotherapy; T cells; macrophages; dendritic cells; single-cell transcriptomics; spatial transcriptomics; artificial intelligence; prognostic biomarkers; predictive biomarkers; personalized therapy

(This special issue belongs to the Section Tumor Microenvironment)

Role of Inflammation in Cancer

edited by

Li Yang

submission deadline 28 Feb 2027 | 2 articles | Viewed by 2123 | Submission Open

Keywords: cancer; inflammation; immune cells; cytokines; anti-inflammatory; tumor microenvironment; immunotherapy; immune-related adverse events; targeted therapy; chemotherapy and chemoprevention

Molecular Mechanisms and Therapeutic Resistance in Hematological Malignancies

edited by

Rui Bergantim

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1998 | Submission Open

Keywords: genomic and epigenomic alterations; signaling pathway dysregulation; non-coding RNAs; metabolic reprogramming; antigen escape mechanisms; antigen presentation defects; interferon signaling impairment; T-cell exhaustion; memory T-cell dysfunction; myeloid-mediated immunosuppression; bone marrow immune microenvironment; spatial immune architecture; CAR-T cell therapy; next-generation CAR engineering; bispecific antibodies and T-cell engagers; antibody-drug conjugates; NK-cell and macrophage immunotherapy; immune checkpoint modulation; combination immunotherapy strategies; liquid biopsy–guided precision therapy

Next-Generation Biomarkers and AI-Enhanced Digital Pathology Alliance: Revolutionizing Therapeutic Strategies and Prognostic Assessment in Colorectal Cancer

edited by

Τaxiarchis Κonstantinos Νikolouzakis

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1965 | Submission Open

Keywords: liquid biopsy; precision oncology; predictive prognostication

Multimodal Management of Hepatobiliary Cancers: Development of Surgical and Locoregional Strategies

edited by

Adrian Bartoș

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1852 | Submission Open

Keywords: hepatocarcinoma; liver metastasis; ultrasound guided liver resection; tumoral ablative tehniques; biliary cancers

Host-Related Prognostic Factors in Gastrointestinal Malignancies: From Genetics to Phenomics

edited by

Kiyohiko Shuto

and Yoshihiro Nabeya

submission deadline 28 Feb 2027 | 3 articles | Viewed by 1668 | Submission Open

Keywords: pharmacogenetics; body composition assessment; nutritional oncology; systemic inflammation; therapeutic management

(This special issue belongs to the Section Molecular Cancer Biology)

Surgery for Head and Neck Cancer

edited by

Boban M. Erovic

Blazen Marijic

and Stefan Grasl

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1539 | Submission Open

Keywords: head and neck cancer; oncologic surgery; minimally invasive surgery; transoral robotic surgery; neck dissection; reconstructive surgery; multidisciplinary treatment; functional outcomes

(This special issue belongs to the Section Cancer Therapy)

Advances in Treatment of Bladder Cancer

edited by

Murat Akand

and

Guglielmo Mantica

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1410 | Submission Open

Keywords: bladder cancer; diagnostic biomarkers; genomics; therapeutic approaches

(This special issue belongs to the Section Cancer Therapy)

Gastrointestinal Tumors: Prevention, Screening and Predictive Analytics

edited by Mohamed I. Elsaid,

Electra D. Paskett

and Vinod Rustgi

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1345 | Submission Open

Keywords: gastrointestinal and hepatobiliary cancers; prevention and screening; chemoprevention; risk stratification; biomarkers and liquid biopsy (ctDNA); imaging and radiomics; predictive analytics and machine learning; causal inference; population-based studies; implementation science and health equity

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Molecular Insights into Drug Resistance in Cancer: 2nd Edition

edited by Yuqi Yang

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1328 | Submission Open

Keywords: drug resistance; cancer treatment; molecular mechanism; chemotherapeutic therapy; small molecules; biologics/large molecules; leukemia; solid tumor

The Molecular Biology of Cholangiocarcinoma

edited by

Kevin Gaston

and Padma-Sheela Jayaraman

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1312 | Submission Open

Keywords: cholangiocarcinoma; biliary tract cancer; early detection; targeted therapy; tumour microenvironment; spatial biology; genomics; transcriptomics; proteomics

(This special issue belongs to the Section Molecular Cancer Biology)

Advancements in Brain Cancer Research: From Molecular Mechanisms to Translational Therapeutic Strategies

edited by

Hernando Lopez-Bertoni

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1271 | Submission Open

Keywords: brain cancer; glioblastoma; tumor microenvironment; cancer stem cells; molecular therapeutics; epigenetic regulation; nanomedicine; translational oncology; therapeutic resistance

Cellular Senescence, Aging and the Tumor Microenvironment in Cancer

edited by Jabed Iqbal and Jeremy Wee Kiat Ng

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1130 | Submission Open

Keywords: aging; senescence; immunosenescence; SASP; tumor microenvironment; immunotherapy

(This special issue belongs to the Section Tumor Microenvironment)

mTOR Signaling in Cancer

edited by

Don Benjamin

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1109 | Submission Open

Keywords: mTOR; cancer; cell signaling; pathway addiction; tumor metabolism; glycolysis; autophagy; apoptosis; rapamycin

(This special issue belongs to the Section Molecular Cancer Biology)

Obesity and Cancers (2nd Edition)

edited by Edward Sauter and Tanya Agurs-Collins

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1029 | Submission Open

Keywords: obesity; cancer; mitigating factors; weight loss; weight gain; obesity interventions

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Robotic and Thoracoscopic Surgery for Lung Cancer

edited by Benjamin Wei

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1019 | Submission Open

Keywords: robotic; thoracoscopic; lobectomy; segmentectomy; wedge resection; lymph node dissection; neoadjuvant therapy; immunotherapy; spread through air spaces; radiomics

(This special issue belongs to the Section Methods and Technologies Development)

Redox Balance, Antioxidant Defenses, and Inflammation in Cancer: From Initial Changes to Tumor Progression

edited by Andrej Veljković,

Gordana Kocic

and

Aleksandra Klisic

submission deadline 28 Feb 2027 | 1 articles | Viewed by 970 | Submission Open

Keywords: oxidative stress; inflammation; cancer progression; pre-malignant changes; biomarkers; tumor microenvironment; cell signaling; therapeutic targets

(This special issue belongs to the Section Tumor Microenvironment)

Role of TP53 Mutation in Cancer

edited by

Naoyuki Iwahashi

submission deadline 28 Feb 2027 | 1 articles | Viewed by 930 | Submission Open

Keywords: TP53 mutation; p53 aggregate; gain-of-function; cancer progression; transcriptional reprogramming; therapeutic targeting; biomarker; translational research; precision oncology

(This special issue belongs to the Section Molecular Cancer Biology)

Surgical Treatment and Prognosis of Hepato-Biliary and Pancreatic Tumors—the Role of Minimally Invasive Surgery

edited by Giorgio Ercolani

submission deadline 28 Feb 2027 | 2 articles | Viewed by 866 | Submission Open

Keywords: liver tumor; cholangiocarcinoma; pancreatic tumor; robotic surgery; mini-invasive treatment; treatment multimodality

Precision Prediction of Cardiotoxicity: Imaging, Biomarkers, Genetics, Risk Models, and Digital Innovation in Cardio-Oncology

edited by Kalliopi Keramida

submission deadline 28 Feb 2027 | 1 articles | Viewed by 824 | Submission Open

Keywords: cardio-oncology; imaging; biomarkers; genetics; risk models; digital innovation

CAR T Cell Therapy in Cancer: Progress and Challenges Across Solid and Hematologic Malignancies

edited by John F. Marshall and Lauren C. Cutmore

submission deadline 28 Feb 2027 | 1 articles | Viewed by 759 | Submission Open

Keywords: CAR-T cell therapy; adoptive cell therapy; immunotherapy; antigen escape; solid tumor; hematologic malignancies

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Recent Developments on PET-CT in Multiple Myeloma

edited by

Carmelo Caldarella

submission deadline 28 Feb 2027 | Viewed by 431 | Submission Open

Keywords: PET/CT; multiple myeloma; novel radiopharmaceuticals; radiomics; theranostics

(This special issue belongs to the Section Methods and Technologies Development)

Advances in the Multimodal Management of Pancreatic Ductal Adenocarcinoma

edited by

Olav F. Dajani

Knut Jørgen Labori

and

Arne Westgaard

submission deadline 28 Feb 2027 | Viewed by 403 | Submission Open

Keywords: pancreatic ductal adenocarcinoma (PDAC); multimodal approach; systemic therapy; radiotherapy; targeted strategies; neoadjuvant therapy; adjuvant therapy

(This special issue belongs to the Section Cancer Therapy)

Tumor Microenvironment in Bone Sarcoma

edited by

Fan Shen

and

Consolato M. Sergi

submission deadline 28 Feb 2027 | Viewed by 371 | Submission Open

Keywords: osteosarcoma; microenvironment; oncogene; tumor suppressor; CAR cell therapy; epithelial–mesenchymal transition; metabolism; epigenetics

(This special issue belongs to the Section Tumor Microenvironment)

Next-Generation Biomarkers in Oncology: From Multi-Omics to AI-Powered Diagnostics

edited by

Caroline G. Lee

submission deadline 28 Feb 2027 | Viewed by 362 | Submission Open

Keywords: multi-omics; cancer biomarkers; precision oncology; liquid biopsy; circulating tumor DNA (ctDNA); single-cell sequencing; spatial transcriptomics; epigenomics; proteogenomics; metabolomics; tumor microenvironment; radiomics; digital pathology; machine learning; explainable AI

(This special issue belongs to the Section Cancer Biomarkers)

Innovative Approaches of Multimodal Imaging of Cancer Characteristics in Nuclear Medicine

edited by

Daniel Gündel

and

Sophie Stotz

submission deadline 28 Feb 2027 | Viewed by 361 | Submission Open

Keywords: multimodal imaging; molecular imaging; PET; SPECT; MRI; CT; ultrasound; optical imaging; cancer

(This special issue belongs to the Section Methods and Technologies Development)

Research on Clinical Treatment of Mesothelioma: 2nd Edition

edited by

Giulia M. Stella

submission deadline 28 Feb 2027 | Viewed by 354 | Submission Open

Keywords: pleural mesothelioma; targeted therapy; local treatments; radiomics; genetic traits; occupational health; asbestos exposure

(This special issue belongs to the Section Clinical Research in Cancer)

Digital Pathology and AI for Tumor Microenvironment Mapping

edited by Mohammadreza Azimi

submission deadline 28 Feb 2027 | Viewed by 333 | Submission Open

Keywords: tumor microenvironment; digital pathology; artificial intelligence; spatial analysis; computational histopathology; deep learning; cancer prognostics; machine learning; image-based biomarkers; federated learning

Liquid Biopsy Innovation: From ctDNA to RNA Modifications in Genitourinary Cancers

edited by

Edoardo Francini

Giuseppe Fanelli

and Jacopo Venturini

submission deadline 28 Feb 2027 | 1 articles | Viewed by 308 | Submission Open

Keywords: liquid biopsy; cell-free DNA (cfDNA); circulating tumor DNA (ctDNA); RNA modification

(This special issue belongs to the Section Cancer Biomarkers)

Epigenetic Markers of Cancer Diseases

edited by

Himanshu Narayan Singh

and Jessica Puzzuoli

submission deadline 28 Feb 2027 | Viewed by 279 | Submission Open

Keywords: epigenetics; DNA methylation; histone modifications; tumor suppressor genes; oncogenes; cancer biomarkers; early detection; disease progression; epigenetic therapy; DNA methyltransferase inhibitors; histone deacetylase inhibitors; liquid biopsy; cancer risk assessment; clinical translation

(This special issue belongs to the Section Molecular Cancer Biology)

Genomic Instability in Breast Cancer: Biomarkers, Resistance and Therapeutic Opportunities

edited by Melyssa R. Bratton

submission deadline 28 Feb 2027 | Viewed by 196 | Submission Open

Keywords: genomic instability; somatic mutation; DNA damage response; homologous recombination deficiency (HRD); tumor mutational burden (TMB); chromosomal instability (CIN); tumor evolution; therapeutic resistance

The Roles of microRNAs and Long Non-Coding RNAs in Cancer

edited by

Mohammad Taheri

submission deadline 28 Feb 2027 | Viewed by 195 | Submission Open

Keywords: microRNAs; long non-coding RNAs; non-coding RNAs; cancer genomics; gene regulation; competing endogenous RNA; tumor microenvironment; therapy resistance; cancer biomarkers; single-cell and multi-omics

(This special issue belongs to the Section Molecular Cancer Biology)

Emerging Roles of HDACs in Cancer Metabolism, Plasticity and Therapeutic Response

edited by Changmin Peng

submission deadline 28 Feb 2027 | Viewed by 183 | Submission Open

Keywords: HDAC biology; cancer metabolism; therapeutic resistance; post-translational modifications; cancer plasticity

(This special issue belongs to the Section Molecular Cancer Biology)

Non-Coding RNAs in Bone Tumors: Pathogenesis, Diagnostic Biomarkers, and Therapeutic Perspectives

edited by Albert Roessner

submission deadline 28 Feb 2027 | Viewed by 182 | Submission Open

Keywords: bone tumors; non-coding RNAs; pathogenesis; biomarkers; non-coding RNA therapeutics

Advances in Pathology of Lymphoma and Leukemia—Second Edition

edited by

Siba El Hussein

submission deadline 28 Feb 2027 | Viewed by 144 | Submission Open

Keywords: leukemia; lymphoma; immunohistochemical stains; next-generation sequencing; cytogenetics; flow cytometry analysis

(This special issue belongs to the Section Cancer Pathophysiology)

Signaling Molecules for Brain Tumors

edited by

Meenakshisundaram Kandhavelu

and Akshaya Murugesan

submission deadline 28 Feb 2027 | Viewed by 137 | Submission Open

Keywords: brain tumor; signaling molecules; tumor microenvironment; sensor; diagnosis and treatment; tumor microenvironment; synthesis and characterization; small drug molecules; gene expression; computational studies

(This special issue belongs to the Section Molecular Cancer Biology)

Artificial Intelligence in Cancers: Enhancing Diagnosis and Treatment

edited by

Rong Wang

, Adam Shephard and Shan E Ahmed Raza

submission deadline 28 Feb 2027 | Viewed by 126 | Submission Open

Keywords: artificial intelligence; machine learning; deep learning; precision oncology; cancer diagnosis; cancer screening; treatment planning; prognostic prediction; digital pathology; medical imaging; radiomics; genomics; multiomics

(This special issue belongs to the Section Cancer Informatics and Big Data)

Displaying special issue 851-900 on page 18 of 22.

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