Tumor Microenvironment in Bone Sarcoma
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: 31 August 2026 | Viewed by 226
Editors
Interests: liver biopsy; cell biology; laboratory medicine; cancer; sarcoma; precision medicine; data science; R software; Python
Special Issues, Collections and Topics in MDPI journals
Interests: pathology; cancer diagnosis; sarcoma; arthro-skeletal diseases; precision medicine; personalized medicine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The bone sarcoma tumor microenvironment (TME) is a complex, dynamic, and immunosuppressive niche composed of malignant cells, bone cells (osteoclasts/osteoblasts), immune cells (Tumor-associated M2 macrophages, Tregs), stromal cells, and a mineralized extracellular matrix (ECM). It promotes tumor growth, metastasis, and therapy resistance by exploiting bone remodeling pathways and creating an immunosuppressive environment. Key components and interactions include (1) bone cells and remodeling, (2) immunologic landscape, (3) mesenchymal stromal cells, and (4) vascular structures. Therapeutic targeting includes immune checkpoints, myeloid reprogramming, and the metabolism intrinsic to the extracellular matrix. We welcome original articles and review articles in this special issue.
Dr. Fan Shen
Prof. Dr. Consolato M. Sergi
Guest Editors
Manuscript Submission Information
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Keywords
- osteosarcoma
- microenvironment
- oncogene
- tumor suppressor
- CAR cell therapy
- epithelial–mesenchymal transition
- metabolism
- epigenetics
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