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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Interrogating Molecular Regulators and Chemical Agents in Brain Tumor Progression

edited by Shilpi Singh

submission deadline 30 Apr 2027 | 3 articles | Viewed by 8298 | Submission Open

Keywords: brain tumor progression; molecular mechanisms; small molecule inhibitors; natural compounds; synthetic drugs; biomarkers; oncogenic pathways; metabolic reprogramming

(This special issue belongs to the Section Tumor Microenvironment)

The Bone Marrow Microenvironment in Myelodysplastic Syndromes—Pathogenesis, Immune Evasion, and Therapeutic Opportunities

edited by

Ciro Roberto Rinaldi

submission deadline 30 Apr 2027 | 2 articles | Viewed by 8264 | Submission Open

Keywords: myelodysplastic syndromes; bone marrow microenvironment; hematopoietic stem cells; mesenchymal stromal cells; immune evasion; CD47; calreticulin; inflammatory cytokines; clonal hematopoiesis; microenvironment-targeted therapy

(This special issue belongs to the Section Tumor Microenvironment)

Tumor Microenvironment Dynamics in Hepatocellular Carcinoma

edited by Joseph Franses and Adam Burgoyne

submission deadline 30 Apr 2027 | 3 articles | Viewed by 7000 | Submission Open

Keywords: liver cancer; immune therapy; biomarkers; treatment resistance; cellular interactions

(This special issue belongs to the Section Tumor Microenvironment)

Personalizing Head and Neck Cancer Care

edited by

Inge Wegner

and

G. B. Halmos

submission deadline 30 Apr 2027 | 3 articles | Viewed by 5664 | Submission Open

Keywords: head and neck cancer; personalized treatment; targeted therapy; prehabilitation; quality of life

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Insulin Resistance, Diabetes, and Cancer: An Overview of the Pathogenetic Mechanisms

edited by

Kumar Ganesan

and

Kunka Mohanram Ramkumar

submission deadline 30 Apr 2027 | 2 articles | Viewed by 3263 | Submission Open

Keywords: insulin resistance; type 2 diabetes; hyperinsulinemia; IGF-1 signaling; tumor microenvironment; metabolic inflammation; adipokines; antidiabetic drugs; cancer metabolism; phytocompounds; bioactive molecules; hormone regulation; intracellular signalling pathways

(This special issue belongs to the Section Cancer Pathophysiology)

Advanced Strategies for Precision Therapy in Urinary Cancers

edited by Menghuan Tang and

Zhaoqing Cong

submission deadline 30 Apr 2027 | 3 articles | Viewed by 2653 | Submission Open

Keywords: urological oncology; precision drug delivery system; nanomaterials; stimuli-responsive delivery; immunotherapy; radioligand therapy

(This special issue belongs to the Section Cancer Therapy)

Risk Factors of Kidney Cancer

edited by

Ken Batai

and

Salvatore La Rosa

submission deadline 30 Apr 2027 | 1 articles | Viewed by 2620 | Submission Open

Keywords: prevention; survivorship; renal cell carcinoma; kidney cancer epidemiology

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Evolving Paradigms in Acute Myeloid Leukemia: From Molecular Risk to Targeted Treatment

edited by Talha Badar

submission deadline 30 Apr 2027 | 2 articles | Viewed by 2498 | Submission Open

Keywords: acute myeloid leukemia; targeted therapy; precision medicine; menin inhibitors; venetoclax; measurable residual disease (MRD); risk stratification; allogeneic hematopoietic cell transplantation; molecular profiling; AML consolidation therapy

Socio-Demographic Factors and Cancer Research: 2nd Edition

edited by

Mitchell S. Fourman

and Amanda N. Goldin

submission deadline 30 Apr 2027 | 3 articles | Viewed by 2292 | Submission Open

Keywords: socio-economic disparity; cancer delivery; cancer survival; metastatic cancer; culture-specific cancer outcomes; AI; machine learning

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Current Applications and Cutting-Edge Innovations in Neuroendoscopy for Oncological Neurosurgery: Where Are We and Where Are We Going?

edited by Giuseppe Roberto Giammalva, Giovanni Tringali and

Giuseppe Cinalli

submission deadline 30 Apr 2027 | 1 articles | Viewed by 2125 | Submission Open

Keywords: neuroendoscopy; endoventricular surgery; skull base surgery; endoscopic assisted neurosurgery; innovations

(This special issue belongs to the Section Methods and Technologies Development)

Clinical Treatment and Outcomes of Gastrointestinal Cancer

edited by Mary Linton Peters

submission deadline 30 Apr 2027 | 3 articles | Viewed by 2037 | Submission Open

Keywords: gastrointestinal cancer; ctDNA; chemotherapy; immunotherapy; financial toxicity; clinical trial participation

(This special issue belongs to the Section Clinical Research in Cancer)

Outcomes in Glioblastoma Patients: From Diagnosis to Palliation: 2nd Edition

edited by

Alba Scerrati

and Giorgio Mantovani

submission deadline 30 Apr 2027 | 2 articles | Viewed by 1991 | Submission Open

Keywords: high-grade glioma; outcome assessment; prognostic factors; neuro-oncology; glioblastoma

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Unraveling Immune Dynamics and Novel Therapeutic Strategies in the Tumor Microenvironment

edited by Shahidul M. Islam

submission deadline 30 Apr 2027 | 1 articles | Viewed by 1970 | Submission Open

Keywords: tumor microenvironment; immune dynamics; tumor heterogeneity; immune checkpoints; CAR T; cancer immunology; adoptive cell transfer; resistance; biomarkers; combination therapy; machine learning; molecular modeling

(This special issue belongs to the Section Tumor Microenvironment)

Combination Therapies in Breast Cancer Chemotherapy: Chemoradiation, Targeted Agents, and Immunotherapy

edited by

Piotr J. Wysocki

submission deadline 30 Apr 2027 | 2 articles | Viewed by 1775 | Submission Open

Keywords: breast cancer; combination therapy; endocrine therapy; chemoradiation; monoclonal antibodies; antibody–drug conjugates (ADCs); small-molecule kinase inhibitors; immunotherapy; predictive biomarkers; therapy resistance; precision oncology; translational research

(This special issue belongs to the Section Cancer Therapy)

Mesothelioma Today: Global Trends, Clinical Challenges, and Policy Responses

edited by

Pierpaolo Ferrante

and Marco Tomasetti

submission deadline 30 Apr 2027 | 2 articles | Viewed by 1509 | Submission Open

Keywords: malignant mesothelioma; asbestos exposure; occupational cancer; epidemiology; public health policy

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Tumour–Immune Interactions in Cancer Therapy

edited by

and

submission deadline 30 Apr 2027 | Viewed by 1173 | Submission Open

Keywords: tumour‑immune interactions; tumour immune microenvironment; immune escape; treatment response; therapy resistance; tumour heterogeneity; immunotherapy; chemotherapy; radiotherapy; targeted therapy; functional genomics; organoids; antigen presentation; translational research; clinical trials; single‑cell & spatial analysis

(This special issue belongs to the Section Molecular Cancer Biology)

Clinical Research in Gynecological Cancers

edited by

Federica Perelli

submission deadline 30 Apr 2027 | 2 articles | Viewed by 1135 | Submission Open

Keywords: gynecologic oncology; hereditary cancer syndrome; BRCA mutation; gynecologic surgery; gynecologic ultrasound; gynecologic oncology prevention; molecular biomarkers; minimally invasive surgery; STIC (serous tubal intraepithelial carcinoma); ovarian cancer; fertility-sparing surgery

(This special issue belongs to the Section Clinical Research in Cancer)

Decoding the Tumor Microenvironment: From Mechanisms to Therapeutic Opportunities

edited by

Michele Zanoni

, Giacomo Miserocchi and

Tania Rossi

submission deadline 30 Apr 2027 | 1 articles | Viewed by 1096 | Submission Open

Keywords: tumor microenvironment (TME); cancer immunology; tumor–stroma interactions Immune; evasion; therapy resistance; spatial and single-cell omics; biomarker discovery; translational oncology; 3D models

(This special issue belongs to the Section Tumor Microenvironment)

Cytoskeleton in Tumor Growth and Progression

edited by David Gau

submission deadline 30 Apr 2027 | 1 articles | Viewed by 998 | Submission Open

Keywords: actin cytoskeleton; microtubules; mechano-transduction; tumor microenvironment; angiogenesis; mitochondria

(This special issue belongs to the Section Molecular Cancer Biology)

Melanoma Combination Therapy: New Horizons, Challenges and Clinical Breakthroughs

edited by Gino K. In, Sanjay Chandrasekaran and

Vincent T. Ma

submission deadline 30 Apr 2027 | 2 articles | Viewed by 879 | Submission Open

Keywords: advanced melanoma; combination checkpoint blockade; targeted therapy; peri-operative therapy; adoptive cellular therapy; intratumoral therapy; rare melanomas; abscopal effect

(This special issue belongs to the Section Cancer Therapy)

From Metronomic Chemotherapy to Time-Optimized Cancer Treatments

edited by

Piotr J. Wysocki

submission deadline 30 Apr 2027 | 1 articles | Viewed by 830 | Submission Open

Keywords: metronomic chemotherapy; time-dependent treatment; chemotherapy; immunotherapy; pharmacokinetics; pharmacodynamics

Advances in the Diagnosis, Pathology and Treatment of Metastatic Brain Tumors

edited by

Mitsugu Fujita

submission deadline 30 Apr 2027 | 1 articles | Viewed by 819 | Submission Open

Keywords: brain metastases; diagnostic imaging; molecular pathology; targeted therapy; immunotherapy; precision oncology; multimodal treatment; translational research

(This special issue belongs to the Section Cancer Metastasis)

Pathological Diagnosis and Surgical Treatment of Cholangiocarcinoma: Current Status and Novel Perspectives

edited by

Masahiko Kinoshita

submission deadline 30 Apr 2027 | 1 articles | Viewed by 733 | Submission Open

Keywords: cholangiocarcinoma; intrahepatic cholangiocarcinoma; small-duct type; large-duct type; immune checkpoint inhibitor; conversion surgery

Innovations in Pathological and Clinical Research in Colorectal Cancer

edited by

Seiichi Shinji

and

Toshiyuki Ishiwata

submission deadline 30 Apr 2027 | 1 articles | Viewed by 607 | Submission Open

Keywords: colorectal cancer; clinicopathological prognostic biomarkers; pathology-guided therapeutic strategies

Emerging Biomarkers for Precision Oncology in Gastrointestinal Cancers

edited by

Alessandro Ottaiano

submission deadline 30 Apr 2027 | 1 articles | Viewed by 566 | Submission Open

Keywords: gastrointestinal cancers; precision oncology; cancer biomarkers; liquid biopsy; next-generation sequencing; predictive biomarkers; tumor microenvironment; cancer immunotherapy biomarkers; molecular profiling; translational oncology

(This special issue belongs to the Section Cancer Biomarkers)

Role of Pathology in Detection, Prognosis and Treatment of Gastrointestinal Cancers

edited by

Cristina Díaz del Arco

and Luís Ortega-Medina

submission deadline 30 Apr 2027 | Viewed by 523 | Submission Open

Keywords: gastrointestinal cancer; pathology; histopathology; molecular pathology; biomarkers; prognosis; precision medicine; digital pathology; cancer detection; targeted therapy

(This special issue belongs to the Section Cancer Pathophysiology)

Modern Radiation Therapy on Refractory Cancer Treatment: Technological Innovations, New Paradigms, Personalized Medicine and Recent Clinical Advances

edited by

Hualin Zhang

submission deadline 30 Apr 2027 | 1 articles | Viewed by 522 | Submission Open

Keywords: adaptive therapy; personalized radiation therapy; refractory cancer; spatially fractionated radiation therapy; minibeam; microbeam; flash therapy

(This special issue belongs to the Section Cancer Therapy)

Advances in Supportive Care in Radiation Oncology

edited by Lukas Käsmann

submission deadline 30 Apr 2027 | 1 articles | Viewed by 498 | Submission Open

Keywords: supportive care; radiation oncology; symptom management; patient-reported outcomes; radiation dermatitis; oral mucositis; cancer survivorship; integrative oncology; quality of life

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Deep Learning for Cancer Image Classification in Smaller Patient Cohorts

edited by

Marko Radulovic

submission deadline 30 Apr 2027 | Viewed by 455 | Submission Open

Keywords: deep learning; deep radiomics; diagnosis; prognosis; prediction

(This special issue belongs to the Section Cancer Informatics and Big Data)

CRLM in the Era of Transplant Oncology: New Hope, New Questions

edited by Brian Davidson and

Khurum Khan

submission deadline 30 Apr 2027 | Viewed by 366 | Submission Open

Keywords: colorectal cancer; liver transplant; transplant oncology; chemotherapy; immunotherapy; immunosuppression; genetic profiling; circulating ccDNA; staging; surveillance

(This special issue belongs to the Section Cancer Therapy)

New Approaches in the Treatment of Hepatocellular Carcinoma and Liver Tumor: 2nd Edition

edited by Riccardo Inchingolo, Stavros Spiliopoulos and Riccardo Memeo

submission deadline 30 Apr 2027 | Viewed by 338 | Submission Open

Keywords: hepatocellular carcinoma; cirrhosis; liver; interventional oncology; trans-arterial chemo embolization; selective internal radiation therapy; ablation; radiology

(This special issue belongs to the Section Cancer Therapy)

Advances in Surgery for Gynecologic Cancer

edited by

Emmanouil Kalampokas

submission deadline 30 Apr 2027 | Viewed by 333 | Submission Open

Keywords: sentinel lymph node mapping; cervical cancer; robotic-assisted laparoscopy; cytoreductive surgery; nerve-sparing techniques; image-guided surgery; enhanced recovery after surgery; molecular staging; individualized surgery; endometrial cancer

Local, Systemic and Combined Therapy for Hepatocellular Carcinoma

edited by Xiaoqun Dong

submission deadline 30 Apr 2027 | Viewed by 330 | Submission Open

Keywords: hepatocellular carcinoma; immunotherapy; cell therapy; targeted therapy; local therapy; combination therapy; oncolytic virus; precision oncology; drug resistance; translational research

(This special issue belongs to the Section Cancer Therapy)

Advances in Diagnosis and Clinical Trials of Bladder Cancer

edited by Mutsuo Furihata

submission deadline 30 Apr 2027 | Viewed by 267 | Submission Open

Keywords: bladder cancer; pathological diagnosis; tumorigenesis; 5-aminolevulinic acid; photodynamic therapies; robot-assisted radical cystectomy; fluorescence navigation; artificial intelligence

Decoding Glioblastoma: Mechanisms, Innovations, and Therapeutic Advancements

edited by

Frances Chow

, Jerica M. Lomax and Yoon Jae Choi

submission deadline 30 Apr 2027 | Viewed by 266 | Submission Open

Keywords: glioblastoma; tumor heterogeneity; resistance; glioma stem cells; multi-omics; molecular targeting; tumor microenvironment; immunotherapy; spatial transcriptomics; epigenetic regulation; metabolic reprogramming; liquid biopsy; radiomics; advanced imaging; nuclear medicine

Epigenomic and Transcriptional Mechanisms in Cancer Progression and Therapy Response

edited by Benjamin L. Kidder

submission deadline 30 Apr 2027 | Viewed by 254 | Submission Open

Keywords: cancer progression; genetic mutations; epigenomic plasticity; tumor heterogeneity; gene regulatory networks; epigenomic mechanisms

(This special issue belongs to the Section Molecular Cancer Biology)

Digestive Tract Cancers: A State-of-the-Art Perspective on Epidemiology, Risk Factors, Molecular Mechanisms, Prevention, Diagnosis and Management

edited by Paraskevi A Farazi

submission deadline 30 Apr 2027 | Viewed by 245 | Submission Open

Keywords: colorectal; pancreatic; liver; biliary; esophageal; stomach cancers; epidemiology; risk factors; molecular mechanisms; prevention; diagnosis; treatment

Beyond Breast Cancer—Rehabilitation for Survivorship

edited by

Elisabeth Kenne Sarenmalm

and

Jenny Nyqvist-Streng

submission deadline 30 Apr 2027 | Viewed by 237 | Submission Open

Keywords: breast cancer; rehabilitation; person-centered: clinical follow-up; physiotherapy; psycho-social support; existential support; patient education and self-management

Advances in MRI Applications for Neuro-Oncology

edited by

Siamak P. Nejad-Davarani

submission deadline 30 Apr 2027 | Viewed by 226 | Submission Open

Keywords: brain tumors; magnetic resonance imaging; MRI field strength; quantitative MRI; radiomics; imaging biomarkers

Molecular Biology for Germ Cell Tumors

edited by

Shi-Ming Tu

submission deadline 30 Apr 2027 | Viewed by 225 | Submission Open

Keywords: germ cell tumors; intratumoral heterogeneity; cancer stem cells; somatic transformation; extragonadal germ cells; subsequent malignant neoplasms

(This special issue belongs to the Section Molecular Cancer Biology)

The Relationship Between Cancers Metabolism and Immunotherapy

edited by Suguru Saito

submission deadline 30 Apr 2027 | Viewed by 217 | Submission Open

Keywords: anti-tumor immunity; metabolism; immunotherapy; macrophages; T cells; exhaustion

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

The Roles of Endoscopies in Gastrointestinal Neoplasm

edited by

Hajime Isomoto

and Hideki Kobara

submission deadline 30 Apr 2027 | Viewed by 179 | Submission Open

Keywords: gastrointestinal cancer; image enhanced endoscopy; early cancer detection; endoscopic submucosal dissection (ESD); endoscopic resection; AI-assisted diagnosis; surveillance endoscopy

(This special issue belongs to the Section Methods and Technologies Development)

Nanocarrier in Cancer Therapy

edited by

Koyeli Girigoswami

submission deadline 30 Apr 2027 | Viewed by 137 | Submission Open

Keywords: nanocarriers; cancer therapy; nanomedicine; targeted drug delivery; stimuli-responsive nanocarriers; tumor microenvironment; nanoparticles; theranostics; drug resistance; precision oncology

(This special issue belongs to the Section Methods and Technologies Development)

Advances in the Surgical Management of Pancreatic Cancer

edited by Richard Zheng and

Avinoam Nevler

submission deadline 30 Apr 2027 | Viewed by 121 | Submission Open

Keywords: pancreatic cancer; pancreatic surgery; pancreatectomy; PDAC; outcomes; minimally invasive surgery; enhanced recovery after surgery (ERAS)

(This special issue belongs to the Section Cancer Therapy)

Emerging Imaging and Radiotherapy Techniques for CNS Tumors

edited by

Tugce Kutuk

and

Joshua D. Palmer

submission deadline 30 Apr 2027 | Viewed by 80 | Submission Open

Keywords: CNS tumors; neuro-oncology; advanced imaging; molecular imaging; MRI; PET imaging; stereotactic radiosurgery (SRS); adaptive radiotherapy; proton therapy; stereotactic body radiotherapy (SBRT)

(This special issue belongs to the Section Methods and Technologies Development)

The Role of Immune Checkpoint Inhibitors in Cancer Therapy

edited by

Min Zhou

submission deadline 30 Apr 2027 | Viewed by 76 | Submission Open

Keywords: immune checkpoint inhibitors; immune checkpoint blockade; PD-1/PD-L1; CTLA-4; LAG-3; bispecific antibodies; predictive biomarkers; immunotherapy resistance; combination immunotherapy

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Molecular Mechanisms and Tumor Heterogeneity in Osteosarcoma

edited by Le Thi Thanh Thuy and

Hidetomi Terai

submission deadline 30 Apr 2027 | Viewed by 74 | Submission Open

Keywords: osteosarcoma; tumor heterogeneity; single-cell RNA sequencing/tumor microenvironment; immune checkpoint proteins and circulating biomarkers; therapeutic targets and translational treatment

(This special issue belongs to the Section Molecular Cancer Biology)

DNA Methylation, Epigenetic Heterogeneity and Biomarkers in Gynecologic Cancers

edited by

Pavol Žúbor

submission deadline 30 Apr 2027 | Viewed by 67 | Submission Open

Keywords: DNA methylation; cancer epigenetics; gynecologic cancers; epigenetic biomarkers; molecular biomarkers; single-cell epigenomics; spatial epigenomics; intratumoral heterogeneity; clonal evolution; tumor evolution; therapy resistance; liquid biopsy; circulating tumor DNA; multi-omics; precision oncology

(This special issue belongs to the Section Molecular Cancer Biology)

Interventional Cancer Pain Management: Current Evidence, Unresolved Questions, and Future Directions

edited by

Giustino Varrassi

and

Matteo Luigi Giuseppe Leoni

submission deadline 30 Apr 2027 | Viewed by 64 | Submission Open

Keywords: cancer pain; pain management; neoplasm metastasis; analgesia; neurosurgical procedures; palliative care

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Functional Preservation and Personalized Surgery in Early-Stage Lung Cancer

edited by

Francesco Petrella

submission deadline 30 Apr 2027 | Viewed by 59 | Submission Open

Keywords: early-stage lung cancer; non-small cell lung cancer (NSCLC); functional preservation; personalized surgery; precision surgery; parenchyma-sparing surgery; segmentectomy; sublobar resection; wedge resection; minimally invasive surgery; robotic-assisted thoracic surgery; video-assisted thoracoscopic surgery (VATS); pulmonary function; quality of life; patient-reported outcomes; frailty; surgical risk stratification; tumor biology; molecular profiling; biomarkers; radiomics; artificial intelligence; image-guided surgery; intraoperative navigation; fluorescence-guided surgery; surgical margins; lymph-node assessment; neoadjuvant therapy; adjuvant therapy; stereotactic body radiotherapy (SBRT); multidisciplinary treatment; personalized medicine

(This special issue belongs to the Section Methods and Technologies Development)

Displaying special issue 801-850 on page 17 of 20.

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