Special Issue "Merkel Cell Carcinoma"


A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: closed (28 February 2014)

Special Issue Editors

Guest Editor
Prof. Adrian Whitehouse
School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK
Website: http://www.fbs.leeds.ac.uk/staff/profile.php?tag=Whitehouse
E-Mail: A.Whitehouse@leeds.ac.uk
Phone: +44 0 113 34 37096
Interests: viruses and cancer: understanding virus host cell interactions which regulate oncogenic virus replication and transformation

Guest Editor
Dr. Andrew Macdonald
School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK
Website: http://www.fbs.leeds.ac.uk/staff/profile.php?tag=Macdonald_A
E-Mail: a.macdonald@leeds.ac.uk
Phone: +44 0 113 343 3053
Interests: transformation and immune evasion strategies of DNA tumour viruses

Special Issue Information

Dear Colleagues,

Merkel cell carcinoma (MCC) is an aggressive form of skin cancer, whose incidence has tripled in the past 20 years. It is a cancer of neuroendocrine origin arising from mechanoreceptor Merkel cells situated in the basal layer of epidermis. MCC has a high mortality rate due to its high propensity for local recurrence and metastasis. In 2008, a novel human polyomavirus was identified associated with the majority of MCC tumor samples. The virus, termed Merkel cell polyomavirus (MCPyV), is monoclonally integrated within the host genome suggesting integration occurs prior to tumor formation and metastasis; hence MCPyV is not a passenger virus. This special issue of Cancers, seeks articles which discuss advances in the understanding of the molecular pathogenesis of MCC, current management regimes, new diagnostic approaches and future therapeutic strategies for MCC.

Prof. Adrian Whitehouse
Dr. Andrew Macdonald
Guest Editors


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed Open Access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 800 CHF (Swiss Francs).


  • Merkel cell
  • skin cancer
  • neuroendocrine carcinoma
  • Merkel cell polyomavirus
  • T antigens
  • MCC staging
  • radiotherapy
  • chemotherapy

Published Papers (1 paper)

Cancers 2013, 5(4), 1566-1576; doi:10.3390/cancers5041566
Received: 11 September 2013; in revised form: 23 October 2013 / Accepted: 8 November 2013 / Published: 18 November 2013
Show/Hide Abstract | Download PDF Full-text (605 KB) | View HTML Full-text | Download XML Full-text |  Supplementary Files

Last update: 12 August 2013

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