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Brain Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Innovation on Neuropsychological and Cognitive Changes in Aging: Assessment and Intervention

edited by Renata Kochhann, Laiss Bertola and

Bernardino Fernández-Calvo

submission deadline 15 May 2026 | 1 articles | Viewed by 903 | Submission Open

Keywords: aging; dementia; neuropsychology; neuropsychological test; non-pharmacological interventions

(This special issue belongs to the Section Neuropsychology)

The Interplay Between the Brain, Behavior and Immunity

edited by

Fatme Seval Ismail

submission deadline 15 May 2026 | Viewed by 474 | Submission Open

Keywords: behavior; therapy; drugs; immunity; neuroinflammation; neurological/psychiatric disorders; clinical studies; in vivo/in vitro models

(This special issue belongs to the Section Behavioral Neuroscience)

Personalised Treatment and Diagnosis of Sleep Disorders

edited by

Dagmara Dimitriou

, Zaid Awad and Mustafa Jaafar

submission deadline 15 May 2026 | Viewed by 128 | Submission Open

Keywords: sleep disorders; obstructive sleep apnoea; personalized treatment; diagnosis; neurodivergence; comorbidities; cross-cultural sleep; wearable technology; paediatric sleep; public health

(This special issue belongs to the Section Sleep and Circadian Neuroscience)

Clinical Research on Pain: Advances and Challenges

edited by Mariateresa Giglio

submission deadline 20 May 2026 | 1 articles | Viewed by 707 | Submission Open

Keywords: pain management; chronic pain; pain research; analgesia; multidisciplinary approach

(This special issue belongs to the Section Sensory and Motor Neuroscience)

Controversies and Challenges in Vestibular Medicine

edited by

Alexander A. Tarnutzer

and

Diego Kaski

submission deadline 20 May 2026 | Viewed by 102 | Submission Open

Keywords: vestibular medicine; emerging treatments; vestibular migraine; controversies in neuro-otology; Meniè re’ s disease; acute vertigo and dizziness

(This special issue belongs to the Section Sensory and Motor Neuroscience)

Advances in Psychosocial and Neurological Aspects in Supportive Cancer Care

edited by

Philip R. Debruyne

Patricia Schofield

and

Laura Tack

submission deadline 22 May 2026 | 1 articles | Viewed by 1457 | Submission Open

Keywords: supportive cancer care; neuropsychology; psychosocial; quality of life; pain management

(This special issue belongs to the Section Neuropsychology)

Mechanisms Underlying the Neuropathic/Chronic Pain Development and Maintenance: Focus on Pharmacological Targets and Therapeutic Approaches

edited by

Giada Amodeo

submission deadline 25 May 2026 | 3 articles | Viewed by 9665 | Submission Open

Keywords: neuropathic pain; chronic pain; mood alteration; neurons; glia cells; cytokines; neuroinflammation

(This special issue belongs to the Section Neuropharmacology and Neuropathology)

The Effect of Lifestyle on Brain Aging and Cognitive Function

edited by

Shuzo Kumagai

Takao Yamasaki

and

Yung Liao

submission deadline 25 May 2026 | Viewed by 288 | Submission Open

Keywords: cognitive function; brain aging; lifestyle; mild cognitive impairment; dementia; prevention and intervention; genetic-environment interaction

(This special issue belongs to the Section Cognitive, Social and Affective Neuroscience)

Advances in Circadian Rhythms, Sleep, and Cognitive Function: Translational and Technological Perspectives

edited by

Maria Comas Soberats

submission deadline 25 May 2026 | Viewed by 131 | Submission Open

Keywords: sleep; circadian rhythms; cognitive function; translational research; telemedicine; wearable technology; light therapy; cognitive behavioral therapy; sleep interventions; neurodevelopmental disorders; neurodegenerative disorders; elderly; adolescence; shift work; non-clinical populations; digital health; chronobiology; sleep health; sleep disorders; circadian disruption; at-risk populations

(This special issue belongs to the Section Sleep and Circadian Neuroscience)

Social and Emotional Processes in Interpersonal Contexts

edited by

Yaoying Xu

and

Yuyan Xia

submission deadline 29 May 2026 | Viewed by 175 | Submission Open

Keywords: social; emotional; social– emotional; interpersonal; cultural relevance; neuroscience; social interaction; interdisciplinary

(This special issue belongs to the Section Cognitive, Social and Affective Neuroscience)

Clinical Research on Parkinson’s Disease: Opportunities and Challenges (2nd Edition)

edited by

Santiago Perez-Lloret

, Matilde Otero-Losada and Francisco Capani

submission deadline 30 May 2026 | 2 articles | Viewed by 2292 | Submission Open

Keywords: Parkinson’ s disease; disease-modifying therapies; clinical research; epidemiology; non-motor symptoms; quality of life; technology; observational studies; randomized controlled trials

(This special issue belongs to the Section Neurodegenerative Diseases)

Mapping the Invisible: Mechanisms and Markers in Cerebral Small Vessel Disease

edited by

Salvatore Rudilosso

submission deadline 30 May 2026 | 1 articles | Viewed by 518 | Submission Open

Keywords: lacunar stroke; small vessel disease; white matter disease; blood– brain barrier; white matter hyperintensities; perivascular spaces; cerebral microbleeds; vascular dementia

(This special issue belongs to the Section Neurosurgery and Neuroanatomy)

Perinatal Psychosis: Symptoms, Diagnosis, and Treatment

edited by

Nusrat Husain

and Siham Sikander

submission deadline 30 May 2026 | Viewed by 72 | Submission Open

Keywords: perinatal psychosis; post partum psychosis; perinatal psychosis detection tools; pharmacological treatment; psycho-social interventions; community based care; community support; perinatal mental health; puerperal psychosis

(This special issue belongs to the Section Neuropsychiatry)

Application of MRI in Brain Diseases

edited by

Carlo A. Mallio

Gianfranco Di Gennaro

and Andrea Elefante

submission deadline 31 May 2026 | 8 articles | Viewed by 16168 | Submission Open

Keywords: magnetic resonance imaging (MRI); medical imaging; neurological disorders; mental disorders; brain diseases; diagnosis; treatment

(This special issue belongs to the Section Neurotechnology and Neuroimaging)

Modulating Brain Network Dynamics Through Training: Impacts on Perception, Cognition, and Action in Health and Disorder

edited by

Mukesh Dhamala

submission deadline 31 May 2026 | 4 articles | Viewed by 8806 | Submission Open

Keywords: perception; cognition; motor actions; behavioral training; music; video game playing; neuroimaging; computational models; physical exercise

(This special issue belongs to the Section Behavioral Neuroscience)

Application of Nerve Stimulation: Current Status and Future Directions—2nd Edition

edited by

Younbyoung Chae

and Hee Young Kim

submission deadline 31 May 2026 | 2 articles | Viewed by 3542 | Submission Open

Keywords: acupuncture; neuroanatomy; neuroimaging; neuromodulation; peripheral nervous system

(This special issue belongs to the Section Neurotechnology and Neuroimaging)

Climate-Related Neurological Problems and Diseases

edited by Karel Kostev

submission deadline 31 May 2026 | 2 articles | Viewed by 1437 | Submission Open

Keywords: climate; heat; stroke; migraine; headache; depression

(This special issue belongs to the Section Environmental Neuroscience)

Genetic and Epigenetic Foundations of Dopaminergic Neurobiology: From Addictions Through Personality Traits and Physical Activity to the Spectrum of Reward-Driven Behaviors

edited by

Anna Grzywacz

and

Remigiusz Recław

submission deadline 31 May 2026 | 1 articles | Viewed by 974 | Submission Open

Keywords: genetic factors; epigenetic regulation; dopaminergic system; substance use disorders; behavioral addictions; personality traits; physical activity and motivation

(This special issue belongs to the Section Neuropsychiatry)

Alzheimer’s Disease: Symptoms, Early Diagnosis, Treatment, and Prevention

edited by Vasileios Papaliagkas

submission deadline 31 May 2026 | 1 articles | Viewed by 620 | Submission Open

Keywords: Alzheimer’ s disease; mild cognitive impairment; clinical neurophysiology; biomarkers; diagnosis; prevention

(This special issue belongs to the Section Neurodegenerative Diseases)

Trends and Challenges in Neuroengineering

edited by

Edgard Morya

submission deadline 31 May 2026 | Viewed by 191 | Submission Open

Keywords: neuroengineering; human interface; brain interface; neuromodulation; neurorobotic; neuroethic; artificial intelligence; neurotechnology; neurorehabilitation

(This special issue belongs to the Section Neural Engineering, Neuroergonomics and Neurorobotics)

Mapping the Brain: Neural Correlates of Cognition and Mental Illness

edited by Giacomo Deste and

Daniele Corbo

submission deadline 31 May 2026 | Viewed by 143 | Submission Open

Keywords: cognition; neural circuits; neurodevelopmental disorders; mental illness

(This special issue belongs to the Section Developmental Neuroscience)

Cerebrovascular Disease: Update on Diagnosis and Treatment

edited by Marialuisa Zedde and Rosario Pascarella

submission deadline 31 May 2026 | Viewed by 130 | Submission Open

Keywords: ischemic stroke; SVD; vasculitides; fibromuscular dysplasia; thrombolysis; EVT; plaque imaging; intracranial stenosis

(This special issue belongs to the Section Neurosurgery and Neuroanatomy)

Inflammation and Its Treatment in Spinal Cord Injury and Neurodegenerative Diseases

edited by Angélica Coyoy-Salgado,

Julio Morán

and

Julia Jeanett Segura-Uribe

submission deadline 31 May 2026 | Viewed by 85 | Submission Open

Keywords: spinal cord injury; neuroprotection; neurodegenerative diseases; oxidative stress; inflammatory biomarkers; neuroregeneration; therapeutic strategies

(This special issue belongs to the Section Neuropharmacology and Neuropathology)

Concussion and Its Rehabilitation

edited by

Ioannis Asterios Mavroudis

and Alin Stelian Ciobică

submission deadline 31 May 2026 | Viewed by 71 | Submission Open

Keywords: concussion; mild traumatic brain injury (mTBI); post-concussion syndrome; neurorehabilitation; brain injury recovery; cognitive impairment; sports-related concussion

(This special issue belongs to the Section Neurorehabilitation)

Current Advances in Intracranial Aneurysms: From Basic to Clinical Research

edited by Yanning Rui and Zhen Xu

submission deadline 10 Jun 2026 | 1 articles | Viewed by 2081 | Submission Open

Keywords: intracranial aneurysm; causes; treatment; clinical trials

(This special issue belongs to the Section Neurosurgery and Neuroanatomy)

Fetal Foundations of Cognition: Tracing Neurodevelopmental Pathways from an Integrated Perspective

edited by Pasquale Anthony Della Rosa and Cristina Baldoli

submission deadline 10 Jun 2026 | Viewed by 444 | Submission Open

Keywords: fetal neurodevelopment; neuroimaging techniques; cognitive outcomes; integrated perspectives; methodological innovations

(This special issue belongs to the Section Developmental Neuroscience)

Advances in Neurorehabilitation of Movement Disorders

edited by

Mariusz Drużbicki

and

Agnieszka Guzik

submission deadline 10 Jun 2026 | Viewed by 118 | Submission Open

Keywords: neurorehabilitation; virtual reality; robotic rehabilitation; advanced technologies; gait

(This special issue belongs to the Section Sensory and Motor Neuroscience)

Using Neuroimaging to Explore Neurodegenerative Diseases

edited by

Ting Shen

submission deadline 15 Jun 2026 | 2 articles | Viewed by 3246 | Submission Open

Keywords: neuroimaging; neurodegenerative diseases; multidisciplinary research; imaging-omics study; multimodal integration; AI-driven analytics

(This special issue belongs to the Section Neurodegenerative Diseases)

Exploration of the Effects of Circadian Rhythms on Behavior and Physiology

edited by Christos Frantzidis and Kalliopi Megari

submission deadline 15 Jun 2026 | Viewed by 409 | Submission Open

Keywords: behavior; chronobiology; computational modeling; depression; immune function; metabolism; neurodegeneration; sleep deprivation; translational neuroscience; wearable technology

(This special issue belongs to the Section Sleep and Circadian Neuroscience)

Neurosurgery on Epilepsy

edited by

Takehiro Uda

submission deadline 15 Jun 2026 | Viewed by 65 | Submission Open

Keywords: epilepsy surgery; stereoelectroencephalography (SEEG); functional neurosurgery; preoperative evaluations; minimally invasive techniques

(This special issue belongs to the Section Neurosurgery and Neuroanatomy)

How to Rewire the Brain—Neuroplasticity

edited by

Jianyang Du

and Hui Lu

submission deadline 19 Jun 2026 | 4 articles | Viewed by 18399 | Submission Open

Keywords: brain circuits; neural networks; synaptic plasticity; neural development; network dynamics; neural coding; information processing; neuron– glia interaction; behavioral output; neurological disorders

(This special issue belongs to the Section Molecular and Cellular Neuroscience)

Neuroimaging and Biomarker-Guided Neuromodulation: Advances in Personalized Brain and Autonomic Stimulation

edited by Mohsen Mosayebi-Samani and

Desmond Agboada

submission deadline 19 Jun 2026 | 4 articles | Viewed by 5646 | Submission Open

Keywords: neuromodulation; brain stimulation; autonomic regulation; neuroimaging; biomarkers; AI-driven Closed-loop Systems; transcranial magnetic stimulation (TMS); transcranial direct current stimulation (tDCS); transcranial alternating current stimulation (tACS); deep brain stimulation (DBS); transcranial ultrasound stimulation (TUS); vagus nerve stimulation (tVNS); heart rate variability (HRV); biofeedback; magnetic resonance imaging (MRI); electroencephalography (EEG); functional near-infrared spectroscopy (fNIRS); epilepsy; depression; stroke; Alzheimer; PTSD; anxiety

(This special issue belongs to the Section Neurotechnology and Neuroimaging)

Advances in Biomedical Research and Clinical Studies of Parkinson’s Disease and Atypical Parkinsonian Disorders

edited by

Frank C. Church

and Stefania Brotini

submission deadline 19 Jun 2026 | Viewed by 435 | Submission Open

Keywords: neurodegenerative diseases; Parkinson’ s disease (PD); atypical parkinsonian disorders (APDs); Alzheimer’ s disease (AD); frontotemporal dementia (FTD); Dementia with Lewy Body (DLB); Multiple System Atrophy Parkinsonian Variant (MSA-P); Progressive Supranuclear Palsy (PSP); Corticobasal Degeneration (CBD); biomarkers of PD and APD; pathophysiology of neurodegeneration in PD and APD; α -synuclein; beta-amyloid; and tau; role of exercise in therapy for neurodegenerative disorders (PD and APD); recent discoveries in the genetics and therapies of neurodegenerative dementias in PD and APD; brain plasticity; Complementary & Alternative Medicine (CAM) approaches in PD and APD; research aimed to understand the role of neuroinflammation in PD and APD; advances in the role of a dysfunctional immune system in the etiology of PD and APD; mitochondria and cellular energy problems in PD and APD.

(This special issue belongs to the Section Neurodegenerative Diseases)

Quality of Life in Older Adults with Musculoskeletal or Neuromuscular Disorders: Assessment and Intervention Strategies

edited by

Tatsunori Ikemoto

submission deadline 20 Jun 2026 | Viewed by 148 | Submission Open

Keywords: musculoskeletal disorder (MSD); neuromuscular disorder (NMD); pain; numbness; muscle weakness; functional decline; quality of life; aging

(This special issue belongs to the Section Sensory and Motor Neuroscience)

Emotional Dysregulation: From Neurodevelopment to Adult Psychopathology—a Transdiagnostic Perspective

edited by

Giulio E. Brancati

submission deadline 20 Jun 2026 | Viewed by 111 | Submission Open

Keywords: emotional dysregulation; affective instability; irritability; neurodevelopmental disorders; transdiagnostic psychopathology; comorbidity; internalizing disorders; externalizing disorders; attention-deficit/hyperactivity disorder; mood disorders

(This special issue belongs to the Section Developmental Neuroscience)

Robot- and Brain Computer Interface Therapies for Neurorehabilitation: Current State of the Art and Applications

edited by

Amin Hekmatmanesh

submission deadline 20 Jun 2026 | Viewed by 98 | Submission Open

Keywords: robot; brain computer interface; neurorehabilitation; machine learning

(This special issue belongs to the Section Neurorehabilitation)

Controlling Emotion: Neural Systems and Psychological Strategies

edited by

Jennifer J. Quinn

submission deadline 20 Jun 2026 | Viewed by 70 | Submission Open

Keywords: neuroplasticity; cortical-subcortical interactions; development; habit; psychopathology; intervention; regulation; cognitive strategies

(This special issue belongs to the Section Neuropsychology)

Research Progress and Insights into Brain Visual Mechanisms

edited by

Thiago P. Fernandes

and

Guifen Chen

submission deadline 20 Jun 2026 | Viewed by 60 | Submission Open

Keywords: visual perception; sensory neuroscience; visual neuroscience; brain mechanisms; neural basis of vision; spatial cognition

(This special issue belongs to the Section Sensory and Motor Neuroscience)

Immune Response Dysregulation in Neurological Infections: Diagnostic and Therapeutic Challenges

edited by

Ryutaro Kajihara

submission deadline 20 Jun 2026 | Viewed by 51 | Submission Open

Keywords: neurological infections; immune response dysregulation; neuroinflammation; diagnostic biomarkers; therapeutic strategies; viral encephalitis; bacterial meningitis; neuroimmunology

(This special issue belongs to the Section Neuropharmacology and Neuropathology)

Alzheimer’s Disease and Dementia: Bridging Clinical Research and Brain Stimulation

edited by

Lucia Mencarelli

submission deadline 20 Jun 2026 | Viewed by 41 | Submission Open

Keywords: Alzheimer’ s disease; dementia; cognitive decline; brain stimulation; transcranial magnetic stimulation (TMS); transcranial electric stimulation (tES); neurorehabilitation; neuromodulation; translational neuroscience

(This special issue belongs to the Section Neurodegenerative Diseases)

Evolved Affects: Evolutionary Perspectives in Affective Neuroscience

edited by

Ivana Hromatko

and

Una Mikac

submission deadline 25 Jun 2026 | Viewed by 155 | Submission Open

Keywords: affective neuroscience; evolutionary psychology; adaptive function of emotions; domain-specificity; proximal mechanisms; neural correlates; hormonal correlates; ecological context; emotion and adaptation

(This special issue belongs to the Section Cognitive, Social and Affective Neuroscience)

Intracranial Pressure Management in Acute Brain Injury

edited by

Alessandro Bertuccio

submission deadline 25 Jun 2026 | Viewed by 90 | Submission Open

Keywords: severe brain trauma injury; subarachnoid hemorrhage (SAH); brain hemorrhage; stroke; intracranial pressure (ICP); monitoring; neurocritical care; biomarkers

(This special issue belongs to the Section Systems Neuroscience)

Astrocytes in Brain Health and Disease: From Development to Neurodegeneration

edited by

Luan Pereira Diniz

submission deadline 28 Jun 2026 | Viewed by 122 | Submission Open

Keywords: astrocytes; mitochondrial dynamics; neuroinflammation; glia– neuron interaction; brain aging; synaptic regulation; neurodegenerative diseases; Alzheimer’ s disease; Parkinson’ s disease; astrocyte-targeted therapy

(This special issue belongs to the Section Neuroglia)

Optimizing Driving Safety: Neurocognitive Insights, Health-Promoting Strategies, and Policy Innovation

edited by

Foteini Christidi

Pinelopi Vlotinou

and

Anna Tsiakiri

submission deadline 30 Jun 2026 | 2 articles | Viewed by 3430 | Submission Open

Keywords: driving; cognitive; sensory; and motor functions; decision-making; public health; aging; brain changes; cognitive decline

(This special issue belongs to the Section Behavioral Neuroscience)

Exploring the Neurobiology of the Sensory-Motor System

edited by

Daya Shankar Gupta

and Hubert Löffler

submission deadline 30 Jun 2026 | 1 articles | Viewed by 3253 | Submission Open

Keywords: sensory; perception; motor; execution; cognitive functions; space of the brain; temporal-spatial; time dimension

(This special issue belongs to the Section Sensory and Motor Neuroscience)

Applications of fMRI (Functional Magnetic Resonance Imaging) in Neuropsychiatry and Neurological Disease

edited by

Vincenzo Alfano

submission deadline 30 Jun 2026 | 1 articles | Viewed by 2272 | Submission Open

Keywords: functional MRI (fMRI); neuropsychiatric disorders; neurological disease; brain connectivity; functional connectivity; neuroimaging; brain networks

(This special issue belongs to the Section Neurotechnology and Neuroimaging)

Perinatal Psychiatry: Mental Health During Pregnancy and the Postpartum

edited by Saulo Gantes Tractenberg,

Thiago Wendt Viola

and Tagma Marina Schneider Donelli

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1384 | Submission Open

Keywords: perinatal; postpartum; mental health; pregnancy; postpartum depression; postpartum psychosis; psychiatric disorders; puerperal disorders; infant; perinatal care

(This special issue belongs to the Section Neuropsychiatry)

Ageing and Visual Working Memory: Cognitive and Neural Perspectives

edited by