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Brain Sciences
Special Issues
Neurosurgery on Epilepsy
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Neurosurgery on Epilepsy

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurosurgery and Neuroanatomy".

Deadline for manuscript submissions: 15 June 2026 | Viewed by 931

Special Issue Editor

Dr. Takehiro Uda

E-Mail Website
Guest Editor
Department of Neurosurgery, Osaka Metropolitan University Graduate School of Medicine, Osaka 545-0051, Japan
Interests: neurophysiology; epilepsy; neurosurgery; electroencephalography; magnetoencephalography
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Epilepsy surgery remains one of the most powerful interventions in modern neuroscience, offering the possibility of freedom from seizure for patients with drug-resistant epilepsy. Advances in neuroimaging, electrophysiology, and surgical techniques have revolutionized the way epileptogenic zones are identified and treated. Neurosurgical strategies continue to evolve toward greater precision and minimal invasiveness, from traditional temporal lobectomy and corpus callosotomy to innovative approaches such as stereoelectroencephalography (SEEG), laser interstitial thermal therapy (LITT), and endoscopic hemispherotomy.

This Special Issue, ‘Neurosurgery on Epilepsy’, invites original research articles, clinical studies, technical notes, case reports, and comprehensive reviews that highlight the current practices and future directions in epilepsy surgery. Submissions focusing on surgical outcomes, patient selection, presurgical evaluation, intraoperative monitoring, imaging-guided planning, and network-based approaches are particularly welcome. By showcasing diverse perspectives from neurosurgeons, neurologists, and neuroscientists, this Special Issue will provide a comprehensive overview of the state of the art in the surgical management of epilepsy, inspiring innovations that will shape the next generation of epilepsy care.

Dr. Takehiro Uda
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • epilepsy surgery
  • stereoelectroencephalography (SEEG)
  • functional neurosurgery
  • preoperative evaluations
  • minimally invasive techniques

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Published Papers (1 paper)

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Research

9 pages, 1247 KB  
Article
Lower Interhemispheric Coherence in Adults with Surgically Treated Severe Generalized Epilepsy than in Patients Without Epilepsy: A Scalp EEG Study
by Shugo Nishijima, Takehiro Uda, Vich Yindeedej, Toshiyuki Kawashima, Yuta Tanoue, Takeshi Inoue, Ichiro Kuki, Masataka Fukuoka, Megumi Nukui, Shin Okazaki, Noritsugu Kunihiro, Ryoko Umaba, Kotaro Ishimoto, Hiroshi Uda and Takeo Goto
Brain Sci. 2026, 16(2), 210; https://doi.org/10.3390/brainsci16020210 - 11 Feb 2026
Viewed by 581
Abstract
Background: Interhemispheric coherence, a coherence value between symmetrically opposite electroencephalography (EEG) electrodes, can be considered as a representation of connectivity through commissural fibers. In general, these commissural fibers are the major pathway of communication between hemispheres. However, in patients with drug-resistant generalized epilepsy [...] Read more.
Background: Interhemispheric coherence, a coherence value between symmetrically opposite electroencephalography (EEG) electrodes, can be considered as a representation of connectivity through commissural fibers. In general, these commissural fibers are the major pathway of communication between hemispheres. However, in patients with drug-resistant generalized epilepsy (GE), these fibers also play an important role in propagating seizure activities to the contralateral hemisphere. The differences in interhemispheric coherence between epilepsy patients and patients without epilepsy (non-E) remain poorly understood. This study compared interhemispheric coherence values between these groups and discussed the potential usage of coherence analysis in the field of epilepsy. Methods: We retrospectively collected EEG data from patients with severe non-lesional GE over 20 years old who underwent corpus callosotomy. To compare interhemispheric coherence, EEG data from 10 non-E patients were prepared. In each patient, EEG data during non-rapid eye movement (NREM) sleep were collected. Interhemispheric coherence in eight pairs of electrodes in five frequency bands was calculated. Interhemispheric coherence values were compared between GE and non-E groups. Results: In each frequency band and electrode pair, interhemispheric coherence values of P3-P4 in delta, C3-C4 in theta, C3-C4 in alpha, F3-F4 and C3-C4 in beta, and C3-C4 and P3-P4 in gamma frequency band were significantly lower for GE than for non-E. The overall interhemispheric coherence value was significantly lower for GE than for non-E. Conclusions: Interhemispheric coherence values were lower for severe GE than for non-E in adults during NREM sleep. Full article
(This article belongs to the Special Issue Neurosurgery on Epilepsy)
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