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Brain Sciences
Special Issues
Concussion and Its Rehabilitation
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Concussion and Its Rehabilitation

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurorehabilitation".

Deadline for manuscript submissions: closed (31 May 2026) | Viewed by 1471

Editors

Dr. Ioannis Asterios Mavroudis

E-Mail Website
Guest Editor
Department of Neurosciences, Leeds Teaching Hospitals, NHS Trust, Leeds LS97TF, UK
Interests: concussion; mild traumatic brain injury (mTBI); post-concussion syndrome (PCS); repetitive head injury; sports-related concussion; military-related concussion; biomechanics of concussion; neuroinflammation; axonal injury; metabolic crisis; neurovascular dysfunction; biomarkers; blood biomarkers; CSF biomarkers; imaging biomarkers; clinical assessment; neuroimaging; MRI; DTI; fMRI; MEG; electrophysiology; EEG; QEEG; evoked potentials; neurocognitive testing; digital diagnostics; eye-tracking; multidisciplinary rehabilitation; physical therapy; vestibular rehabilitation; cognitive rehabilitation; occupational therapy; speech and language therapy; pharmacological interventions; non-invasive brain stimulation; TMS; tDCS; pediatric concussion; adolescent athletes; female athletes; military personnel; veterans; older adults; return-to-play; return-to-learn; return-to-work; recovery trajectories; risk factors for prolonged symptoms; chronic traumatic encephalopathy (CTE); digital health tools; tele-rehabilitatio
Special Issues, Collections and Topics in MDPI journals
Dr. Alin Stelian Ciobică

E-Mail Website
Guest Editor
Faculty of Biology, Alexandru Ioan Cuza University, Iasi, Romania
Interests: neuropsychiatry; oxidative stress; models

Special Issue Information

Dear Colleagues,

Concussion, a form of mild traumatic brain injury (mTBI), represents a major public health concern due to its high incidence and potential for long-term symptoms, including cognitive, emotional, and physical impairments. Although traditionally considered a transient injury, a significant subset of patients experiences prolonged recovery, highlighting the need for improved understanding and targeted rehabilitation strategies.

This Special Issue seeks to consolidate current research and clinical advancements in the diagnosis, treatment, and rehabilitation of concussion. Emphasis will be placed on the pathophysiological mechanisms of injury, identifying predictive factors for recovery, and developing innovative neurorehabilitation techniques and interdisciplinary approaches to managing persistent symptoms.

We welcome contributions exploring neuroimaging biomarkers, digital and wearable technologies, neurocognitive therapies, exercise-based interventions, and AI-driven diagnostic tools. Studies focusing on vulnerable populations, such as athletes, military personnel, and children, are particularly encouraged.

Original research articles, systematic and narrative reviews, case series, and clinical trials are all welcome, particularly those addressing mechanisms, rehabilitation strategies, and translational neuroscience in the context of concussion.

Dr. Ioannis Asterios Mavroudis
Dr. Alin Stelian Ciobică
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • concussion
  • mild traumatic brain injury (mTBI)
  • post-concussion syndrome
  • neurorehabilitation
  • brain injury recovery
  • cognitive impairment
  • sports-related concussion

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Published Papers (2 papers)

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Research

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26 pages, 1665 KB  
Article
A Diagnostic Framework for the Management of Post-Concussion Visually Induced Dizziness: Recognising Postural and Visuoperceptual Subtypes Using an Optokinetic Balance Assessment
by Meyer Samuel, Beppi Carolina, Bockisch J. Christopher, Penner Marco, Straumann Dominik and Feddermann-Demont Nina
Brain Sci. 2026, 16(7), 719; https://doi.org/10.3390/brainsci16070719 - 4 Jul 2026
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Abstract
Background/Objectives: Dizziness is highly prevalent in patients with concussion, with a significant proportion of these patients experiencing visually induced dizziness (VID) in complex visual environments. As current diagnoses rely primarily on subjective questionnaires, establishing objective diagnostic frameworks remains a challenge. This study aimed [...] Read more.
Background/Objectives: Dizziness is highly prevalent in patients with concussion, with a significant proportion of these patients experiencing visually induced dizziness (VID) in complex visual environments. As current diagnoses rely primarily on subjective questionnaires, establishing objective diagnostic frameworks remains a challenge. This study aimed to quantify responses to optokinetic stimulation to explore potential clinical subtypes based on objective postural and subjective symptom measures. Methods: Concussed patients and healthy controls underwent optokinetic stimulation, with patients stratified into High and Low VVAS groups by the median Visual Vertigo Analogue Scale (VVAS) score. Induced postural metrics and symptoms were statistically compared and modelled to establish a framework for subtype classification of VID. Results: Patients with High VVAS exhibited significantly greater postural instability and higher symptom scores during optokinetic stimulation than healthy controls. While mean induced postural performance and dizziness in patients with Low VVAS were comparable to healthy controls, this patient cohort demonstrated increased heterogeneity in individual responses. Regression modelling successfully distinguished patients with High VVAS from healthy controls, achieving strong diagnostic accuracy for the postural (AUC = 0.815) and symptom-based (AUC = 0.958) models. Using this diagnostic framework, distinct postural and visuoperceptual subtypes were identified within the visual–vestibular mismatch cohort. Conclusions: This study provides a robust framework for post-concussive VID by combining objective postural metrics with subjective induced symptom scales. This classification identifies distinct clinical subtypes and characterises specific manifestations to facilitate tailored rehabilitation programmes. Future research should investigate whether these findings can guide targeted and individualised programmes to optimise rehabilitation. Full article
(This article belongs to the Special Issue Concussion and Its Rehabilitation)
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Review

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14 pages, 815 KB  
Review
Hybrid Evidence-Informed Synthesis of Resting-State Functional Connectivity Alterations in Mild Traumatic Brain Injury
by Ioannis Mavroudis, Foivos Petridis, Alin Ciobica, Roxana O. Cojocariu, Dimitrios Kazis, Ahmed Adel Mansour Kamar, Cătălina Ionescu, Diana Gheban, Catalin Morosan, Bogdan Gurzu, Otilia Novac and Bogdan Novac
Brain Sci. 2026, 16(6), 557; https://doi.org/10.3390/brainsci16060557 - 23 May 2026
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Abstract
Background: Mild traumatic brain injury (mTBI) is frequently followed by persistent cognitive, affective, and sensory complaints despite unremarkable conventional structural imaging. Resting-state functional MRI (rs-fMRI) has been increasingly employed to detect subtle alterations in large-scale brain networks. However, variability in analytical approaches and [...] Read more.
Background: Mild traumatic brain injury (mTBI) is frequently followed by persistent cognitive, affective, and sensory complaints despite unremarkable conventional structural imaging. Resting-state functional MRI (rs-fMRI) has been increasingly employed to detect subtle alterations in large-scale brain networks. However, variability in analytical approaches and the potential influence of neurovascular factors complicate interpretation of BOLD-derived connectivity findings. Objective: This study provides a focused, evidence-informed synthesis integrating umbrella review principles with a targeted narrative analysis of recent high-quality rs-fMRI studies in mild traumatic brain injury (mTBI). Rather than a comprehensive systematic review, the aim was to identify convergent patterns of network dysfunction while critically examining methodological constraints, including neurovascular confounds and variability in analytical approaches. Conclusions: This synthesis supports a network-level model of mTBI characterized by distributed connectivity disturbances. However, given the limited number of eligible studies and substantial methodological heterogeneity, findings should be interpreted as qualitative convergence rather than quantitative generalization. Future longitudinal, multimodal, and standardized imaging approaches are required to clarify the translational relevance of rs-fMRI findings. Full article
(This article belongs to the Special Issue Concussion and Its Rehabilitation)
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