Mapping the Invisible: Mechanisms and Markers in Cerebral Small Vessel Disease
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurosurgery and Neuroanatomy".
Deadline for manuscript submissions: 30 May 2026 | Viewed by 23
Special Issue Editor
2. August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Rosselló 149, 08036 Barcelona, Spain
Interests: small vessel disease; imaging
Special Issue Information
Dear Colleagues,
This Special Issue aims to bring together innovative research that explores the critical and often overlooked aspects of cerebral small vessel disease (CSVD). As a significant contributor to stroke, cognitive decline, and neuropsychiatric disorders, CSVD presents unique diagnostic and therapeutic challenges due to its subtle clinical signs and variability in radiological correlates. This issue showcases advancements in neuroimaging, fluid biomarkers, and neuropathological techniques that lead to earlier detection of CSVD, enabling better monitoring of its progression and a deeper understanding of the mechanisms driving vascular dysfunction, inflammation, and blood–brain barrier breakdown. By bridging basic science with clinical practice, this collection emphasizes the importance of interdisciplinary approaches to uncover the often-neglected clinical significance of CSVD.
Dr. Salvatore Rudilosso
Guest Editor
Manuscript Submission Information
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Keywords
- lacunar stroke
- small vessel disease
- white matter disease
- blood–brain barrier
- white matter hyperintensities
- perivascular spaces
- cerebral microbleeds
- vascular dementia
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