Alzheimer’s Disease: Symptoms, Early Diagnosis, Treatment, and Prevention

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurodegenerative Diseases".

Deadline for manuscript submissions: 31 May 2026 | Viewed by 630

Special Issue Editor


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Guest Editor
Department of Biomedical Sciences, Alexander Campus, International Hellenic University, P.O. Box 141, Sindos, 57400 Thessaloniki, Greece
Interests: Alzheimer’s disease; clinical neurophysiology; mild cognitive impairment
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Special Issue Information

Dear Colleagues,

Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease, characterized by progressive memory impairment, and functional deterioration, and it is believed to affect over 55 million people worldwide. Despite significant advances in neuroscience and clinical practice, early diagnosis and effective therapeutic strategies remain limited. 

This Special Issue, “Alzheimer’s Disease: Symptoms, Early Diagnosis, Treatment, and Prevention”, welcomes original articles, reviews, and case reports that address the multifactorial nature of AD. We invite contributions that include clinical and neuropathological characterization, advances in neuroimaging, neurophysiology, and other biomarkers, and innovative diagnostic tools for early detection. Equally emphasized are pharmacological and non-pharmacological interventions, lifestyle and dietary approaches, and preventive strategies aimed at delaying onset or mitigating progression. 

Dr. Vasileios Papaliagkas
Guest Editor

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Keywords

  • Alzheimer’s disease
  • mild cognitive impairment
  • clinical neurophysiology
  • biomarkers
  • diagnosis
  • prevention

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Published Papers (1 paper)

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Research

15 pages, 242 KB  
Article
Factors Associated with the Social Behaviour of People with Alzheimer’s Dementia: A Video Observation Study
by Jasmine Shaw, Fern Rodgers, Deniz Eda Kavustu, Yuding Wang, Sarah Assaad, Gill Livingston and Andrew Sommerlad
Brain Sci. 2025, 15(11), 1205; https://doi.org/10.3390/brainsci15111205 - 8 Nov 2025
Viewed by 474
Abstract
Background/Objectives: People with Alzheimer’s dementia (AD) experience distressing changes in social behaviour. However, little is understood about whether social behaviour is associated with support provided by, or familiarity with, conversation partners. We aimed to explore the association between support provided by, and familiarity [...] Read more.
Background/Objectives: People with Alzheimer’s dementia (AD) experience distressing changes in social behaviour. However, little is understood about whether social behaviour is associated with support provided by, or familiarity with, conversation partners. We aimed to explore the association between support provided by, and familiarity with, conversation partners and the social behaviour of people with mild AD during conversation. Method: We designed an exploratory within-subjects study wherein conversations between 19 participants with mild AD and a familiar informant, followed by an unfamiliar researcher, were video-recorded and double-rated using two measures of social behaviour (Social Observation Inventory and Measure of Participation in Conversation—Dementia), and one measure of support from the conversation partner (Measure of Support in Conversation—Dementia). Multilevel linear regression with within-subject clusters was used to explore adjusted associations between support and familiarity and social behaviour. Results: Greater support in conversation was associated with more appropriate participation in social conversation of participants with AD. In fully adjusted models, every 1-point increase in MSC-D score was associated with a 0.29 (95% CI: 0.14 to 0.44) increase in MPC-D score and a 1.59 (95% CI: 0.87 to 2.32) increase in SOI score. Familiarity with the conversation partner was not associated with the social behaviour of the participants with AD. Conclusions: We found evidence for an association between social behaviour in AD and support provided by unimpaired conversation partners, but the numbers were small, and this should be interpreted cautiously. Future research should continue this hypothetical lead to expand our understanding of how support and familiarity influence social behaviour to inform potential interventions. Full article
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