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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Photosynthetic Adaptation and Photoprotection in Plants

edited by

Roland Valcke

submission deadline 28 Feb 2026 | Viewed by 83 | Submission Open

Keywords: pigment– protein complexes; excess energy; quenching; photoprotection; electron transport; reactive oxygen species

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Alcohol-Related Nervous System Damage and Disease: From Mechanisms to Therapies

edited by

Suzanne M. De La Monte

submission deadline 14 Mar 2026 | 1 articles | Viewed by 439 | Submission Open

Keywords: alcohol; brain; neurodegeneration; diagnostics; treatment; disease mechanisms; prevention; pathology; imaging; molecular and cellular studies; co-factor effects

(This special issue belongs to the Section Molecular Medicine)

Molecular Insights into Treatment and Prognosis of Autoimmune Bullous Diseases

edited by Kristina Seiffert-Sinha and Animesh A. Sinha

submission deadline 15 Mar 2026 | 1 articles | Viewed by 1245 | Submission Open

Keywords: autoimmunity; blistering; gene expression; immunome; keratinocyte; pathomechanism; proteome; skin

(This special issue belongs to the Section Molecular Medicine)

Molecular Insights into Bronchiolitis Obliterans

edited by Ralf Schubert and Silvija-Pera Jerkic

submission deadline 15 Mar 2026 | Viewed by 103 | Submission Open

Keywords: bronchiolitis obliterans (BO); inflammation; fibrosis; molecular mechanisms

(This special issue belongs to the Section Molecular Medicine)

Molecular Effects of Environmental Pollutants on Health of Human, Animals and Plants, 2nd Edition

edited by

Marina Piscopo

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1745 | Submission Open

Keywords: health damage; reproductive health; environmental pollution; epigenetics; human; animals and plants

(This special issue belongs to the Section Natural and Bio-derived Molecules)

DNA Damage Response for Targeted Cancer Therapy: Molecular Basis and Mechanisms Pathways

edited by

Renata Krupa

submission deadline 20 Mar 2026 | Viewed by 209 | Submission Open

Keywords: DNA repair; targeted cancer therapy; DNA damage response; predictive factors; gene editing; personalized cancer therapy

(This special issue belongs to the Section Molecular Biology)

Future Innovation and Challenges in Bioactive Compounds from Plant Foods: Towards Sustainable Health

edited by

Giacomo Fais

and

Giorgia Sarais

submission deadline 20 Mar 2026 | Viewed by 178 | Submission Open

Keywords: bioactive compounds; plant-based foods; functional phytochemicals; sustainable nutrition; nutraceuticals; eco-friendly extraction; agro-industrial byproducts; microalgae and cyanobacteria; food waste valorization; innovative food systems

The Kynurenine Pathway in Mood Disorders: From Mechanisms to Therapeutics

edited by Gregory F. Oxenkrug

submission deadline 27 Mar 2026 | Viewed by 114 | Submission Open

Keywords: kynurenine; tryptophan; mood disorders; stress; inflammation

(This special issue belongs to the Section Biological Factors)

Research Progress on Anti-Aging with Natural Products

edited by

Sang-Han Lee

submission deadline 29 Mar 2026 | 2 articles | Viewed by 2806 | Submission Open

Keywords: natural products; anti-aging signaling; autophagy; antioxidants; skin aging; bioactive compounds; molecular mechanisms; translational applications

(This special issue belongs to the Section Biological Factors)

Advances in Lysosomal Disorders: From Molecular Mechanisms to Diagnosis

edited by

Gianandrea Pasquinelli

and Irene Capelli

submission deadline 29 Mar 2026 | Viewed by 81 | Submission Open

Keywords: Fabry disease; lysosomal disorders; globotriaosylceramide (GB3); inherited disease; GLA-gene; nephropathy; hypertrophic cardiomyopathy; small fiber neuropathy

(This special issue belongs to the Section Molecular Medicine)

Biogenic Amines, Their Receptors and Transporters in Health and Disease: Commemorative Issue in Honor of Professor Marc G. Caron (1946–2022)

edited by

Raul Gainetdinov

Bruno Giros

, Jean Martin Beaulieu and Stephen S.G. Ferguson

submission deadline 31 Mar 2026 | 16 articles | Viewed by 64233 | Submission Open

Keywords: dopamine; serotonin; norepinephrine; epinephrine; histamine; trace amines; beta-phenylethylamine; GPCR; TAAR

(This special issue belongs to the Section Biological Factors)

Esophageal Diseases: Molecular Basis and Therapeutic Approaches

edited by

Hiroshi Nakagawa

and Amanda B. Muir

submission deadline 31 Mar 2026 | 6 articles | Viewed by 17431 | Submission Open

(This special issue belongs to the Section Molecular Medicine)

The Role of Astrocytes in Neurodegenerative Diseases

edited by

Nima Sanadgol

submission deadline 31 Mar 2026 | 4 articles | Viewed by 13702 | Submission Open

Keywords: astrocytes; neurodegeneration; neuroinflammation; neuroprotection; neuroregeneration

(This special issue belongs to the Section Cellular Biochemistry)

Molecular Mechanisms and Novel Therapeutic Approaches of Neurodegenerative Diseases

edited by

Zhidong Zhou

submission deadline 31 Mar 2026 | 6 articles | Viewed by 11166 | Submission Open

Keywords: neurodegenerative disease; therapeutic approaches; molecular mechanisms; RNA-based therapies; gene therapy; small-molecule inhibitors; immunotherapy

(This special issue belongs to the Section Biological Factors)

State of the Art and Perspectives in Retinal Pigment Epithelium

edited by

Paola Secchiero

and

Elisabetta Melloni

submission deadline 31 Mar 2026 | 3 articles | Viewed by 9975 | Submission Open

Keywords: retinal pigment epithelium; innovative treatments/therapeutic approaches; retinal diseases; bioactive molecules; eye delivery strategy

(This special issue belongs to the Section Cellular Biochemistry)

Metabolic Pathways, COVID-19 and Other Viral Acute Respiratory Infections: Mechanisms and Clinical Implications: 2nd Edition

edited by

Simona Iftimie

and

Jordi Camps

submission deadline 31 Mar 2026 | 3 articles | Viewed by 7605 | Submission Open

Keywords: COVID-19; respiratory syncytial virus; influenza; SARS-CoV-2; viral acute respiratory infections; metabolic pathways; herpes virus

(This special issue belongs to the Section Molecular Medicine)

Novel Antimicrobial Strategies for Animal Health

edited by

Anna Aris

and

Elena Garcia-Fruitos

submission deadline 31 Mar 2026 | 2 articles | Viewed by 7532 | Submission Open

Keywords: antimicrobial alternatives; antimicrobial resistance; animal health; infectious disease

(This special issue belongs to the Section Molecular Medicine)

Molecular Advances in Drug Resistance and Novel Therapies for Cancer

edited by

Agnieszka Wolnicka-Glubisz

and

Konrad Kleszczyński

submission deadline 31 Mar 2026 | 4 articles | Viewed by 7401 | Submission Open

Keywords: cell signalling; cancer treatment; cancer metastasis; target validation; cancer and new molecules; cancer and cellular organelles

(This special issue belongs to the Section Biological Factors)

Advances in Nano-Based Drug Delivery: Unveiling the Next Frontier

edited by

Yuping Bao

and

Jessica M. Larsen

submission deadline 31 Mar 2026 | 3 articles | Viewed by 7217 | Submission Open

Keywords: targeted drug delivery; smart nanoformulation; controlled drug release; biocompatible nanocarriers; extracellular vesicles; immunotherapy

(This special issue belongs to the Section Bio-Engineered Materials)

Stem Cells in Musculoskeletal Tissue Engineering

edited by

Chenshuang Li

and

Zhong Zheng

submission deadline 31 Mar 2026 | 2 articles | Viewed by 4605 | Submission Open

Keywords: tissue regeneration; stem cell; cell reporgramming; iPSCs

(This special issue belongs to the Section Bio-Engineered Materials)

The Role of Glycosaminoglycans and Proteoglycans in Human Disease

edited by

Umesh Desai

submission deadline 31 Mar 2026 | 3 articles | Viewed by 4268 | Submission Open

Keywords: glycosaminoglycans (GAGs); proteoglycans (PGs); diseases; mechanisms; molecules

(This special issue belongs to the Section Molecular Biology)

New Discoveries in the Field of Neuropharmacology

edited by

Beatrice Mihaela Radu

and Bogdan Amuzescu

submission deadline 31 Mar 2026 | 2 articles | Viewed by 3276 | Submission Open

Keywords: neurologic and psychiatric diseases pharmacology; in silico drug screening; in vitro pharmacology assays; animal models; neuropharmacogenomics; drug safety; blood brain barrier; electrophysiology; patch-clamp

(This special issue belongs to the Section Molecular Medicine)

Unraveling the Complexity of Autoimmune and Autoinflammatory Skin Diseases: From Molecular Pathways to Targeted Therapies

edited by

Chiara Moltrasio

Angelo Valerio Marzano

and

Sergio Crovella

submission deadline 31 Mar 2026 | 1 articles | Viewed by 3182 | Submission Open

Keywords: autoimmune/autoinflammatory skin diseases; omics; bioinformatics; pathogenesis; tailored medicine

(This special issue belongs to the Section Molecular Genetics)

Advances in Glycosaminoglycans (GAGs) and Mimetics

edited by

Daniel Afosah

and

Rami A. Al-Horani

submission deadline 31 Mar 2026 | 2 articles | Viewed by 2656 | Submission Open

Keywords: glycosaminoglycans (GAGs); hyaluronan; heparin; chondroitin sulfate; keratan sulfate; dermatan sulfate; sulfation; GAG mimetics; GAG-binding proteins

(This special issue belongs to the Section Chemical Biology)

Advanced Therapeutic Strategies for Hormone-Dependent Cancers

edited by

Athanasios A. Panagiotopoulos

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1574 | Submission Open

Keywords: hormone-dependent cancers; endocrine therapy resistance; targeted therapy; combination treatment strategies; cancer biomarkers

(This special issue belongs to the Section Molecular Medicine)

Updates on Molecular Mechanisms of Lysosomal Storage Disease

edited by

Anna Tylki-Szymanska

and

Patryk Lipiński

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1482 | Submission Open

Keywords: lysosomal storage disease (LSD); molecular mechanisms of LSD; genetic analyses; genotype– phenotype correlation in LSD; molecular biomarkers in LSD; gene therapy in LSD

(This special issue belongs to the Section Biological Factors)

Light as a Tool to Manipulate the Structure and Function of Membranes and Membrane Proteins

edited by

Peter Pohl

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1444 | Submission Open

Keywords: photopharmacology; optogenetics; membrane transport; light-gated channels; photoswitchable lipids

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Breast Cancer: Molecular Pathology, Drug Resistance and Novel Treatment Strategies

edited by

Yesim Gökmen-Polar

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1343 | Submission Open

Keywords: breast cancer; mechanism of resistance; targeted therapy resistance; ER+; HER2; TNBC; tumor microenvironment; recurrence; metastasis; tumor evasion

(This special issue belongs to the Section Molecular Medicine)

Extracellular Vesicles and Their Roles in Cancer Progression

edited by

Federica Calore

and

Giovanni Nigita

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1294 | Submission Open

Keywords: extracellular vesicles; tumor microenvironment; biomolecule profiling; multi-omics; cancer biomarkers

(This special issue belongs to the Section Molecular Biology)

From Gene to Metabolite: Decoding the Transcriptional Regulatory Networks Controlling the Biosynthesis of Bioactive Compounds

edited by

Zhenming Yu

submission deadline 31 Mar 2026 | 1 articles | Viewed by 687 | Submission Open

Keywords: bioactive compounds; transcriptional regulation; abiotic and biotic factor; exogenous elicitor

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Bioinspired and Biomimicking Materials for Biomedical Applications: Second Edition

edited by

Bahman Anvari

submission deadline 31 Mar 2026 | Viewed by 582 | Submission Open

Keywords: biomedical and biological imaging; biophotonics; biosensors; cell-based therapy; delivery systems; theranostics

Advances in Genetic and Epigenetic Gene Therapy for Diabetic Wound Healing

edited by

Kanhaiya Singh

submission deadline 31 Mar 2026 | 1 articles | Viewed by 514 | Submission Open

Keywords: chronic wounds; DFU; wound healing; diet; diabetes; obesity; nutrition; genomics; epigenetics; DNA methylation; histone modifications

(This special issue belongs to the Section Molecular Genetics)

Molecular Advances in Stress Response, Growth, Development, and Breeding of Horticultural Crops

edited by

Bo Sun

Xin Li

and Jian Lyu

submission deadline 31 Mar 2026 | 1 articles | Viewed by 511 | Submission Open

Keywords: horticultural crops; multi-omics integration; genome editing; molecular plant breeding; abiotic and biotic stress; quality; metabolic pathways; plant hormones; transcriptional and epigenetic regulation; protein interaction networks

(This special issue belongs to the Section Biological Factors)

Tissue-Specific Organelle Dynamics

edited by

Agnese De Mario

and

Marta Giacomello

submission deadline 31 Mar 2026 | Viewed by 359 | Submission Open

Keywords: organelles crosstalk; organelles contact sites; organelle dynamics

(This special issue belongs to the Section Cellular Biochemistry)

Fibrinogen and Fibrin in Human Diseases

edited by

Abha Sahni

submission deadline 31 Mar 2026 | Viewed by 249 | Submission Open

Keywords: fibrinogen; fibrin; inflammation; cardiovascular; neurological; endothelium; thrombosis; hemostasis; fibrosis

(This special issue belongs to the Section Molecular Biology)

Protein Arginine Methylation: Functions, Mechanisms, and Therapeutic Implications

edited by Yanzhong Yang

submission deadline 31 Mar 2026 | Viewed by 227 | Submission Open

Keywords: protein arginine methyltransferases; transcription; RNA splicing; signaling transduction; DNA repair; cancer; development; small molecule inhibitor

(This special issue belongs to the Section Molecular Genetics)

Nutritional Immunity and Inflammation: Decoding Mechanisms for Therapeutic Advancement

edited by

Franziska Roth-Walter

and

Carolina Frizzo-Ramos

submission deadline 31 Mar 2026 | Viewed by 211 | Submission Open

Keywords: nutritional deficiencies; antioxidants; minerals; vitamins; mucosal block; cross feeding; microbes; inflammation; tolerance

Molecular Chaperones in Neurodegenerative Diseases: Mechanistic Role and Therapeutic Potential

edited by Umesh Kumar Jinwal

submission deadline 31 Mar 2026 | Viewed by 186 | Submission Open

Keywords: molecular chaperones; neurodegenerative diseases; Hsp90; Hsp70; Alzheimer's Disease; Parkinson’ s Disease; Huntington's disease; amyotrophic lateral sclerosis

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Genetics and Molecular Mechanisms of Parkinson's Disease

edited by

Hugo Fernandes

submission deadline 31 Mar 2026 | Viewed by 170 | Submission Open

Keywords: Parkinson’ s disease; genetics; molecular mechanisms; neurodegeneration

(This special issue belongs to the Section Molecular Genetics)

Targeted Protein Degradation and Beyond: Integrated Biological, Chemical and Computational Approaches to Proximity-Based Modulation

edited by

Gabriele La Monica

and

Antonino Lauria

submission deadline 31 Mar 2026 | Viewed by 159 | Submission Open

Keywords: PROTACs; protein degradation; drug discovery; chemical biology; ternary complex; undruggable targets

Zebrafish: A Powerful Model in Neuroscience to Investigate Genes, Brain Mechanisms, and Behavior

edited by

Marco Dal Maschio

Nicola Facchinello

and

Maria Elena Miletto Petrazzini

submission deadline 31 Mar 2026 | Viewed by 135 | Submission Open

Keywords: zebrafish; behavioural neuroscience; neurodevelopment; neurodegeneration

(This special issue belongs to the Section Chemical Biology)

The Role of Heparin in Blood

edited by

Viktoria Weber

Stephan Harm

and Denisa Cont

submission deadline 31 Mar 2026 | Viewed by 132 | Submission Open

Keywords: heparin; glycocalyx; anti-inflammatory properties; immunothrombosis; sepsis; inflammation; hemocompatibility; extracorporeal therapies; antiviral activity; heparin-induced thrombocytopenia (HIT)

(This special issue belongs to the Section Molecular Medicine)

Obesity-Related Diseases: Molecular Basis and Therapeutic Approaches

edited by

Dénes Molnár

and

Szilvia Bokor

submission deadline 31 Mar 2026 | Viewed by 129 | Submission Open

Keywords: obesity; causes; therapy; epigenetics; biomolecules

Structure, Molecular Dynamics, Assembly, and Evolution of Protein Systems with AI-Enhanced Modeling in Pharmacology and Structural Biology

edited by

Michal Blazej Ponczek

and

Mohamed Ragab AbdelGawwad

submission deadline 31 Mar 2026 | Viewed by 129 | Submission Open

Keywords: machine learning in structural biology; molecular dynamics simulations; protein– ligand interactions; computational pharmacology; structure-based drug design

(This special issue belongs to the Section Molecular Biology)

Post-Translational Modifications in Disease: From Computational Prediction to Functional Mechanisms

edited by

Mengsha Tong

submission deadline 31 Mar 2026 | Viewed by 122 | Submission Open

Keywords: post-translational modifications; PTMs; disease

Exploring the Molecular and Cellular Mechanisms of Pulmonary Arterial Hypertension

edited by

Fabrice Antigny

and Grégoire Ruffenach

submission deadline 31 Mar 2026 | Viewed by 116 | Submission Open

Keywords: pulmonary arterial hypertension; PAH predisposing genes; ion channels; transcription factors; RNA-binding protein; omics approaches

(This special issue belongs to the Section Molecular Medicine)

SAM Domains in Health and Diseases: Structural and Functional Insights

edited by

Flavia Anna Mercurio

and

Marilisa Leone

submission deadline 31 Mar 2026 | Viewed by 111 | Submission Open

Keywords: SAM domains; oligomer- and polymer-forming SAM; mid-loop/end-helix architecture of binding; SAM physiological and pathological signaling pathways; SAM domains as drug targets

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Amino Acids and Their Metabolism in Disease

edited by

Toshiyuki Kitoh

submission deadline 31 Mar 2026 | Viewed by 110 | Submission Open

Keywords: amino acid metabolism; disease pathophysiology; cancer metabolism; immunometabolism; metabolic reprogramming; amino acid transporters; therapeutic targeting; biomarkers; nutrient sensing; systems biology

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Citrin Deficiency: Molecular Pathogenesis and Novel Targets for Therapy

edited by

Takeyori Saheki

submission deadline 31 Mar 2026 | Viewed by 93 | Submission Open

Keywords: citrin deficiency; pathogenesis; therapeutic procedures

(This special issue belongs to the Section Molecular Medicine)

Fibronectin, Integrins and Related Molecules in Health and Diseases

edited by