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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Glutamate and Glutamate Receptors in Health and Diseases, Second Edition

edited by

Jolanta H. Kotlińska

and

Marta Marszalek-Grabska

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1149 | Submission Open

Keywords: glutamate receptors; addiction; pain; learning and memory; anxiety; depression; autism; neurodegeneration

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Novel Therapeutic Approaches of Neurodegenerative Diseases

edited by

Zhidong Zhou

submission deadline 31 Aug 2025 | 1 articles | Viewed by 868 | Submission Open

Keywords: neurodegenerative disease; therapeutic approaches; molecular mechanisms; RNA-based therapies; gene therapy; small-molecule inhibitors; immunotherapy

(This special issue belongs to the Section Biological Factors)

New Insights into Autacoids in Disease

edited by

Katsutoshi Yayama

submission deadline 31 Aug 2025 | Viewed by 849 | Submission Open

Keywords: angiotensin; bradykinin; endothelin; prostaglandins; thromboxanes; leukotrienes; serotonin; histamine; angiotensin-converting enzyme; angiotensin receptor; renin; kininogen; kallikrein; cyclooxygenase; phospholipase A2

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms and Pathophysiology of Gliomas

edited by Fengchao Lang

submission deadline 31 Aug 2025 | 1 articles | Viewed by 555 | Submission Open

Keywords: gliomas; cell cycle; epigenetic modifications; metabolic reprogramming; tumor microenvironment; targeted therapies

(This special issue belongs to the Section Molecular Biology)

Bioactive Compounds as Modifiers of Mitochondrial Function

edited by Mihail "Mike" Mitov

submission deadline 31 Aug 2025 | Viewed by 548 | Submission Open

Keywords: natural bioactive compounds; synthesized bioactive compounds; mitochondrial function; electron transport chain (ETC); ATP production rate; oxygen consumption rate (OCR); extracellular acidification rate (ECAR)

(This special issue belongs to the Section Natural and Bio-derived Molecules)

State-of-the-Art Protein X-Ray Crystallography

edited by Wu-Pei Su and

Hongxing He

submission deadline 31 Aug 2025 | Viewed by 532 | Submission Open

Keywords: ab initio phasing methods; X-ray crystallography; protein structural determination; image reconstruction from Fourier amplitudes; iterative projection algorithms; phasing with deep learning methods

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Cellular and Molecular Mechanisms of Endometriosis: 2nd Edition

edited by

Luciana Bordin

, Alessandra Andrisani and Chiara Sabbadin

submission deadline 31 Aug 2025 | 1 articles | Viewed by 489 | Submission Open

Keywords: endocrine disfunction in endometriosis; glycosylphosphatidylinositols (GPIs) and GPI-anchored proteins; oxidative stress markers (glutathione; carbonic anhydrase; etc.); endometriosis and deep endometriosis; endometriosis-related immune system

(This special issue belongs to the Section Molecular Biology)

Applications of NMR Spectroscopy in Structure-Based Drug Discovery

edited by Alexander L. Breeze and Reto Walser

submission deadline 31 Aug 2025 | Viewed by 452 | Submission Open

Keywords: NMR; structural biology; structure-based drug discovery; fragment screening; lead generation

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Advances in Purinergic Signaling Research: From Molecular Biology to Human Diseases

edited by Ricardo Rodrigues

submission deadline 31 Aug 2025 | Viewed by 307 | Submission Open

Keywords: ATP; adenosine; P1 receptors; P2 receptors; P2X receptors; P2Y receptors; ecto-nucleotidases

(This special issue belongs to the Section Molecular Biology)

Biomolecular Sciences and Precision Medicine in Vascular Disease

edited by

Raffaele Serra

submission deadline 31 Aug 2025 | Viewed by 254 | Submission Open

Keywords: precision medicine; vascular disease; vascular surgery

(This special issue belongs to the Section Molecular Medicine)

Regenerative Medicine in Wound Healing and Tissue Engineering

edited by

Jie Ding

submission deadline 31 Aug 2025 | Viewed by 159 | Submission Open

Keywords: wound healing; regeneration medicine; tissue engineering

Oxidative Stress and Ferroptosis in Health and Disease

edited by Udayakumar Karunakaran and Suma Elumalai

submission deadline 31 Aug 2025 | Viewed by 141 | Submission Open

Keywords: reactive oxygen species; antioxidants; glutathione; iron; H2S signaling; diabetes; metabolic disease; mitochondrial biology; ferroptosis; cell death; inflammation; aging; neurodegenerative diseases

Tumor Genomics and Liquid Biopsy in Cancer Biology

edited by

Milena Urbini

submission deadline 31 Aug 2025 | Viewed by 132 | Submission Open

Keywords: circulating tumor DNA (ctDNA); circulating tumor cells (CTCs); exosomes and extracellular vesicles; circulating free RNAs and microRNAs; tumor heterogeneity; mechanisms of metastasis; tumor clonal evolution; drug resistance; tumor microenvironment; multi-omics integration

(This special issue belongs to the Section Molecular Biology)

Probiotics and Their Metabolites, 2nd Edition

edited by

Hary Razafindralambo

submission deadline 31 Aug 2025 | Viewed by 126 | Submission Open

Keywords: probiotics; metabolites; functionality; biochemical aspects; biophysical aspects; physicochemical approach; molecular mechanism; interaction; synergy; adhesion; colonization; stability; prebiotics; postbiotics; synbiotics; viability; formulation; rational design; human health; animal health; plant health

Cellular and Molecular Mechanisms in Cardiorenal Syndrome

edited by

Rosemary Wangensteen

, María Carmen Ruiz Fuentes and Maria José Espigares Huete

submission deadline 31 Aug 2025 | Viewed by 111 | Submission Open

Keywords: cardiorenal syndrome; renal failure; heart; kidney; heart failure

(This special issue belongs to the Section Molecular Biology)

Small Aquatic Organisms as a Model for Predictive Toxicology and Stress Mechanisms

edited by Tetsuhiro Kudoh

submission deadline 31 Aug 2025 | Viewed by 108 | Submission Open

Keywords: fish model; zebrafish model; chemical toxicology

DNA Damage Response for Targeted Cancer Therapy: Molecular Basis and Mechanisms Pathways

edited by

Renata Krupa

submission deadline 31 Aug 2025 | Viewed by 72 | Submission Open

Keywords: DNA repair; targeted cancer therapy; DNA damage response; predictive factors; gene editing; personalized cancer therapy

(This special issue belongs to the Section Molecular Biology)

Advances in Antiviral Drug Development

edited by Angel S. Galabov

submission deadline 31 Aug 2025 | Viewed by 66 | Submission Open

Keywords: viral inhibitors; mechanism of action; antiviral tests

Updates on Molecular Mechanisms of Lysosomal Storage Disease

edited by

Anna Tylki-Szymanska

and

Patryk Lipiński

submission deadline 31 Aug 2025 | Viewed by 63 | Submission Open

Keywords: lysosomal storage disease (LSD); molecular mechanisms of LSD; genetic analyses; genotype– phenotype correlation in LSD; molecular biomarkers in LSD; gene therapy in LSD

(This special issue belongs to the Section Biological Factors)

Hyaluronic Acid and Proteoglycans: Basic and Biomedical Applications: 2nd Edition

edited by

Michele Scuruchi

submission deadline 31 Aug 2025 | Viewed by 56 | Submission Open

Keywords: hyaluronic acid; proteoglycans; GAGs; extracellular matrix; hyaluronic acid and proteoglycans in disease; cancer; inflammation; angiogenesis; vascular homeostasis and damage; arthritis and arthrosis; glycobiology

Genetics and Molecular Mechanisms of Parkinson's Disease

edited by

Hugo Fernandes

submission deadline 31 Aug 2025 | Viewed by 52 | Submission Open

Keywords: Parkinson’ s disease; genetics; molecular mechanisms; neurodegeneration

(This special issue belongs to the Section Molecular Genetics)

Advances in Nano-Based Drug Delivery: Unveiling the Next Frontier

edited by

Yuping Bao

and

Jessica M. Larsen

submission deadline 15 Sep 2025 | 1 articles | Viewed by 2777 | Submission Open

Keywords: targeted drug delivery; smart nanoformulation; controlled drug release; biocompatible nanocarriers; extracellular vesicles; immunotherapy

(This special issue belongs to the Section Bio-Engineered Materials)

Roles of Alpha-1 Antitrypsin in Human Health and Disease Models

edited by

Sihong Song

submission deadline 15 Sep 2025 | 1 articles | Viewed by 1568 | Submission Open

Keywords: alpha-1 antitrypsin; serine proteinase inhibitor (SERPIN); autoimmunity; inflammation; aging; cancer

(This special issue belongs to the Section Molecular Medicine)

Molecular Insights into Treatment and Prognosis of Autoimmune Bullous Diseases

edited by Kristina Seiffert-Sinha and Animesh A. Sinha

submission deadline 15 Sep 2025 | Viewed by 344 | Submission Open

Keywords: autoimmunity; blistering; gene expression; immunome; keratinocyte; pathomechanism; proteome; skin

(This special issue belongs to the Section Molecular Medicine)

Recent Advances in Bioactive Compounds from Microalgae

edited by

Giuseppe Martelli

and

Rosa Paola Radice

submission deadline 15 Sep 2025 | Viewed by 59 | Submission Open

Keywords: microalgae; bioactive compounds; biomolecules; innovations

Dysregulated Cytokine Signals in Human Disease

edited by

Alister C. Ward

submission deadline 25 Sep 2025 | Viewed by 259 | Submission Open

Keywords: cytokine; signaling; dysregulation; immunity; development; disease

(This special issue belongs to the Section Molecular Medicine)

Molecular Aspects of Diseases Origin and Development

edited by

Natalia Kurhaluk

submission deadline 30 Sep 2025 | 6 articles | Viewed by 13635 | Submission Open

(This special issue belongs to the Section Molecular Medicine)

Diabetes, Overweight and Obesity: From Molecular Mechanisms to Therapies Strategies

edited by

Othmar Moser

and

Harald Sourij

submission deadline 30 Sep 2025 | 7 articles | Viewed by 13306 | Submission Open

Keywords: diabetes mellitus; overweight; obesity; molecular mechanisms; microbiome; liver metabolism; advanced therapy

(This special issue belongs to the Section Molecular Medicine)

Prebiotics and Probiotics in Health and Disease: Looking at the Future

edited by

Pio Maria Furneri

Virginia Fuochi

and

Giovanna Furneri

submission deadline 30 Sep 2025 | 7 articles | Viewed by 10560 | Submission Open

Keywords: probiotics; live biotherapeutic product (LBP); next-generation probiotic (NGP); prebiotic; synbiotic/symbiotic; pharmabiotics; post-biotics; paraprobiotic/ghost probiotics/inactivated probiotics; probioceuticals/probiotaceuticals; biogenic; gut balance; gut– brain axis; vaginal homeostasis; vaginal microbiota modification or augmentation; oral microbiota; skin microbiota; new therapeutic approaches using bacteria; psychobiotics

(This special issue belongs to the Section Molecular Medicine)

The Role of Vascular Dysfunction in Neuronal Degeneration and Cognitive Impairment (2nd Edition)

edited by

David Lominadze

submission deadline 30 Sep 2025 | 7 articles | Viewed by 9815 | Submission Open

Keywords: blood cells; plasma components; vascular wall components; neurovascular unit; neuroinflammation; cognitive decline

(This special issue belongs to the Section Molecular Biology)

Amyloid-Beta and Alzheimer’s Disease

edited by

Fumiaki Ito

and

Toshifumi Akizawa

submission deadline 30 Sep 2025 | 6 articles | Viewed by 8589 | Submission Open

Keywords: Alzheimer's disease (AD); amyloid-beta (Aβ ); neurotoxicity of Aβ ; Tau protein; Aβ phagocytosis; Aβ clearance; autophagy– lysosome system; anti-Aβ monoclonal antibodies; neuroinflammation in AD; glial cells in AD

(This special issue belongs to the Section Cellular Biochemistry)

Recent Advances in the Role of Translation Machinery and Translational Control in the Cardiovascular System

edited by Peng Yao and

Wei Guo

submission deadline 30 Sep 2025 | 4 articles | Viewed by 5273 | Submission Open

Keywords: translational control; translation machinery; RNA-binding protein; non-coding RNA

(This special issue belongs to the Section Molecular Medicine)

The Structure and Function of Neurotransmitter Receptors and Transporters: From Molecular Biology to Translational Research

edited by Riccardo Fesce

submission deadline 30 Sep 2025 | 1 articles | Viewed by 4765 | Submission Open

Keywords: neurotransmitters; receptors; neurotransporters; structure– function relationship; neuropharmacology

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Pathogenesis and Neuropathology of Alzheimer's Disease

edited by

Venkata Atluri

and

Fanpeng Zhao

submission deadline 30 Sep 2025 | 4 articles | Viewed by 4453 | Submission Open

Keywords: Alzheimer disease; pathogenesis; neuropathology; diagnosis; neurodegenerative diseases; microRNA as diagnostic marker; the important modulatory action of DNA repair enzyme DNA-PKcs in synaptic plasticity

(This special issue belongs to the Section Molecular Medicine)

Health and Environmental Effect of Advanced Materials and Fine Particles: 2nd Edition

edited by

Il Je Yu

submission deadline 30 Sep 2025 | 1 articles | Viewed by 4365 | Submission Open

Keywords: advanced materials; fine particles; nanoparticles; nanomaterials; ultrafine particles; health effect; environmental effect; risk assessment; toxicity; exposure; biomaterials

(This special issue belongs to the Section Molecular Medicine)

Oxidative Stress and Inflammation in Aging and Cancer: Biological Bases, Therapeutic Strategies and Opportunities

edited by

Antonio Garrido

submission deadline 30 Sep 2025 | 1 articles | Viewed by 3511 | Submission Open

Keywords: ROS; inflammatory compounds; oxidative stress; chronic inflammation; aging; cancer; immunomodulation; antioxidant strategies; exercise; nutrition

(This special issue belongs to the Section Biological Factors)

Mitochondria and Central Nervous System Disorders: 3rd Edition

edited by

Marta Zaninello

and

Camilla Bean

submission deadline 30 Sep 2025 | 3 articles | Viewed by 3243 | Submission Open

Keywords: mitochondria; metabolism; neurodegeneration; neuroinflammation; ageing; central nervous system

(This special issue belongs to the Section Molecular Biology)

Lipids Metabolism in Cardiovascular Disease

edited by Anand K. Rohatgi

submission deadline 30 Sep 2025 | 1 articles | Viewed by 2780 | Submission Open

Keywords: lipid; lipoprotein; vascular disease; therapy; atherosclerosis

(This special issue belongs to the Section Molecular Medicine)

Redox Balance and Proteostasis Surveillance in Neurodegenerative Disorders

edited by

Fabio Di Domenico

and

Antonella Tramutola

submission deadline 30 Sep 2025 | 1 articles | Viewed by 2597 | Submission Open

Keywords: redox homeostasis; oxidative stress; antioxidant response; proteostasis; protein folding; protein oxidation; unfolded protein response; ubiquitin proteosome system; autophagy; neurodegeneration

(This special issue belongs to the Section Molecular Medicine)

Biomarkers of Cardiovascular and Cerebrovascular Diseases, 2nd Edition

edited by

Ana Catarina Fonseca

submission deadline 30 Sep 2025 | 3 articles | Viewed by 1782 | Submission Open

Keywords: biomarkers; cardiovascular disease; cerebrovascular disease; cardiovascular therapy; diagnosis

(This special issue belongs to the Section Molecular Biomarkers)

Cellular Quiescence and Dormancy

edited by

Jürg Bähler

submission deadline 30 Sep 2025 | 3 articles | Viewed by 1569 | Submission Open

Keywords: quiescent cells; dormant cells; biostasis; diapause; spores; dauer larva

(This special issue belongs to the Section Molecular Genetics)

Molecular Mechanisms and Therapeutic Targets in Leukaemia

edited by

Sabrina Tosi

and

Denise Ragusa

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1401 | Submission Open

Keywords: leukaemia; blood; genetics; genomics; chromosome

(This special issue belongs to the Section Molecular Medicine)

Experimental and Bioinformatic Approaches for Biomarker Discovery in Disease: From Molecular Mechanisms to Therapeutic Challenges

edited by

Valeria Gasperi

Maria Valeria Catani

and

Alessandra Gambacurta

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1260 | Submission Open

Keywords: biomarker; molecular biology; bioinformatics

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Stem Cells in Musculoskeletal Tissue Engineering

edited by

Chenshuang Li

and

Zhong Zheng

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1045 | Submission Open

Keywords: tissue regeneration; stem cell; cell reporgramming; iPSCs

(This special issue belongs to the Section Bio-Engineered Materials)

Recent Advances in Anti-Tumor Metal Complexes and Drug Delivery Systems: 2nd Edition

edited by Jasmina Dimitrić Marković,

Goran Kaluđerović

and

Dušan Dimić

submission deadline 30 Sep 2025 | 1 articles | Viewed by 923 | Submission Open

Keywords: transition metal complexes; synthesis; structural characterization; biological activity; in silico methods; drug delivery

Role of Postbiotics on Health Maintenance and Recovery

edited by

Luigi Santacroce

submission deadline 30 Sep 2025 | 1 articles | Viewed by 596 | Submission Open

Keywords: human microbiota; postbiotics; lantibiotics; SCFAs; SCFAs receptors; immune regulation; synbiotics; psychobiotics; dysbiosis; TMAO

(This special issue belongs to the Section Molecular Biology)

Mechanisms, Biology and Regulation of Proteasomes—in Memory of Professor Alfred L. Goldberg (1942–2023)

edited by

Galen A. Collins

and Alexander John Dear

submission deadline 30 Sep 2025 | 1 articles | Viewed by 518 | Submission Open

Keywords: proteasomes; ubiquitin; protease mechanisms; protease inhibitors; ATPases; muscle atrophy; antigen presentation

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

State of the Art and Perspectives in Retinal Pigment Epithelium

edited by

Paola Secchiero

and

Elisabetta Melloni

submission deadline 30 Sep 2025 | Viewed by 486 | Submission Open

Keywords: retinal pigment epithelium; innovative treatments/therapeutic approaches; retinal diseases; bioactive molecules; eye delivery strategy

(This special issue belongs to the Section Cellular Biochemistry)

Breast Cancer: Molecular Pathology, Drug Resistance and Novel Treatment Strategies

edited by

Yesim Gokmen-Polar

submission deadline 30 Sep 2025 | Viewed by 474 | Submission Open

Keywords: breast cancer; mechanism of resistance; targeted therapy resistance; ER+; HER2; TNBC; tumor microenvironment; recurrence; metastasis; tumor evasion

(This special issue belongs to the Section Molecular Medicine)

Identifying New Therapeutic Targets for Psychiatric Disease Using Transcriptomics and Epigenomics

edited by