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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances and Novel Strategies for Studying Underexplored Post-Translational Modifications (PTMs)

edited by

Yue Chen

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2057 | Submission Open

Keywords: post-translational modifications proteomics; chemical biology; cell signaling; epigenetics; metabolic regulation; cancer; diabetes; microbiome; aging

(This special issue belongs to the Section Molecular Biology)

Key Molecules Regulating Plant Response to Abiotic Stress: Transcription Factors and Stress-Induced Proteins

edited by

Fei Gao

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1701 | Submission Open

Keywords: abiotic stress response; transcription factors; stress-induced proteins; molecular mechanisms; transcriptomics; omics; bioinformatics

(This special issue belongs to the Section Molecular Biology)

Current Advances of Metal Complexes for Biomedical Applications

edited by

Marcelino Maneiro

and

Sandra Fernández-Fariña

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1601 | Submission Open

Keywords: metal complexes; metals in medicine; bioinorganic; anti-cancer; antiviral; anti-inflammatory; antioxidant; imaging applications

(This special issue belongs to the Section Chemical Biology)

Effects of Weightlessness on Molecular Changes in Cellular Organisms, Animals and Plants: 2nd Edition

edited by

Daniela Grimm

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1407 | Submission Open

Keywords: cells; humans; animals; plants; microorganisms; microgravity; weightlessness; cancer research; tissue engineering; space-related health problems

(This special issue belongs to the Section Cellular Biochemistry)

State-of-the-Art Protein X-Ray Crystallography

edited by Wu-Pei Su and

Hongxing He

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1344 | Submission Open

Keywords: ab initio phasing methods; X-ray crystallography; protein structural determination; image reconstruction from Fourier amplitudes; iterative projection algorithms; phasing with deep learning methods

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Developmental Biology of the Kidney: From Molecular Mechanisms to Congenital Disorders

edited by

Katarina Vukojević

and Anita Racetin

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1237 | Submission Open

Keywords: kidney development; renal physiology; kidney disease; molecular mechanisms; cellular signaling; gene expression; biomarkers; renal pathophysiology; therapeutic targets

(This special issue belongs to the Section Molecular Medicine)

Lung Disease: From Molecular Mechanism to Therapeutic Opportunities

edited by

Patrick G. Arndt

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1043 | Submission Open

Keywords: biomarkers; pharmacotherapeutics; cell signaling; innate immunity; inflammation

(This special issue belongs to the Section Molecular Biology)

Cellular and Molecular Basis of Parasite Infection

edited by

Adekunle Sanyaolu

and

Ricardo Izurieta

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1026 | Submission Open

Keywords: parasite infection; host– parasite interaction; cellular invasion; molecular mechanisms; immune evasion

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms, Novel Diagnostics and Treatments of Gynecologic Cancer

edited by Panneerdoss Subbarayalu

submission deadline 31 Jan 2026 | 1 articles | Viewed by 757 | Submission Open

Keywords: biomarker; cancer biology; novel drug targets and therapeutics; cancer stem cells; tumorigenesis

(This special issue belongs to the Section Molecular Medicine)

Inflammation Biology in Orthodontic Tooth Movement

edited by

Masaru Yamaguchi

submission deadline 31 Jan 2026 | Viewed by 394 | Submission Open

Keywords: orthodontic tooth movement; inflammation; cytokine; root resorption; accelerated orthodontic tooth movement; relapse

(This special issue belongs to the Section Biological Factors)

Mechanisms of Gene Regulation in Embryos

edited by

Jo Qian

and Adam Davis

submission deadline 31 Jan 2026 | Viewed by 327 | Submission Open

Keywords: embryonic development; gene regulation; epigenetics; transcriptional control; post-transcriptional control; translational control; post-translational modification; signaling pathways; developmental disorders

(This special issue belongs to the Section Molecular Biology)

Advances in Molecular Therapy Targeting DNA Damage and Repair Systems

edited by

Joy Mitra

Anirban Chakraborty

and Anahita Mojiri

submission deadline 31 Jan 2026 | Viewed by 317 | Submission Open

Keywords: DNA repair; DNA repair inhibitors; homologous recombination; genome instability; inflammation; DNA damage; cell death; apoptosis

(This special issue belongs to the Section Biological Factors)

Focus on Perineural Invasion in Pancreatic Cancer

edited by

Ingrid Garajová

submission deadline 31 Jan 2026 | Viewed by 296 | Submission Open

Keywords: pancreatic cancer; perineural invasion; pain; NGF; neutrophins

(This special issue belongs to the Section Molecular Medicine)

The Role of Extracellular Vesicles in Drug Delivery

edited by

Davide Brocco

submission deadline 31 Jan 2026 | Viewed by 286 | Submission Open

Keywords: extracellular vesicles; drug delivery systems; extracellular vesicle engineering; cancer treatment; gene therapy

(This special issue belongs to the Section Molecular Biology)

Genomics and Molecular Biology of Solid Tumors

edited by Dragoş Creţoiu and Silviu Cristian Voinea

submission deadline 31 Jan 2026 | Viewed by 268 | Submission Open

Keywords: solid tumors; tumor microenvironment; genomic instability; cancer stem cells; liquid biopsy

(This special issue belongs to the Section Molecular Biology)

Metabolic Diseases: From Molecular Mechanisms to Therapy Strategies

edited by

Livia Lenzini

and

Nicola Vitturi

submission deadline 31 Jan 2026 | Viewed by 233 | Submission Open

Keywords: inborn errors of metabolism; molecular mechanisms; gene identification; therapeutic; approaches; translation

New Insights into Mesothelial Cells

edited by Francesca Bodega and Cristina Porta

submission deadline 31 Jan 2026 | Viewed by 227 | Submission Open

Keywords: mesothelial cells; serous cavities; lubricating fluids; epithelial– mesenchymal transition; fibrosis; tissue repair; mesothelioma; tumor microenvironment; immune response

(This special issue belongs to the Section Molecular Biology)

Molecular Biology and Therapy of Breast Cancer

edited by

Norbert Nass

submission deadline 31 Jan 2026 | Viewed by 197 | Submission Open

Keywords: breast cancer; molecular pathology; biomarkers; novel therapy targets; personalized therapy; immunotherapy; tumor microenvironment; tumor stem cells; therapy resistance; non-coding RNA

Nucleic Acid-Lipid Interactions: Bridging Molecular Insights with Therapeutic Applications

edited by Weiwei He and Serdal Kirmizialtin

submission deadline 31 Jan 2026 | Viewed by 178 | Submission Open

Keywords: nucleic acids; lipid membranes; interactions; structural transitions; physical mechanism

Epigenetic Regulation of Vascular Smooth Muscle Cells During Development and Disease

edited by

Melina M. Musri

and

Victor I. Peinado

submission deadline 31 Jan 2026 | Viewed by 177 | Submission Open

Keywords: vascular smooth muscle cells; cell phenotypic change; epigenetics; gene expression regulation; cell differentiation

(This special issue belongs to the Section Molecular Biology)

Synthesis, Characterization and Validation of Small Molecule Compounds

edited by Mohamed Fares Metwaly

submission deadline 31 Jan 2026 | 1 articles | Viewed by 138 | Submission Open

Keywords: medicinal chemistry; structure-based drug design; enzyme inhibitors; multi-target therapeutics

(This special issue belongs to the Section Molecular Biology)

Endometriosis: Molecular Pathogenesis and Translational Implications

edited by

Ie-Ming Shih

submission deadline 31 Jan 2026 | Viewed by 135 | Submission Open

Keywords: endometriosis; pathogenesis; adenomyosis; diagnosis; detection

(This special issue belongs to the Section Molecular Medicine)

Genetic and Epigenetic Mechanisms Underlying Neurodevelopmental Disorders

edited by

Andrea L. Gropman

submission deadline 31 Jan 2026 | Viewed by 134 | Submission Open

Keywords: neurodevelopmental disorders; epigenetics; gene– environment interaction; chromatin remodeling; neurogenomics

(This special issue belongs to the Section Molecular Genetics)

Mechanisms in Stress-Related Disorders, Anxiety and Fear

edited by Veronica Begni

submission deadline 31 Jan 2026 | Viewed by 129 | Submission Open

Keywords: stress-related disorders; anxiety; fear; genetic and environmental interactions; behavioral neuroscience; biological pathways; biomarkers; therapeutic interventions

(This special issue belongs to the Section Molecular Biology)

Alcohol Consumption as a Cardiovascular Risk Factor: Focusing on Molecular Mechanisms

edited by

Ichiro Wakabayashi

and

Klaus Groschner

submission deadline 31 Jan 2026 | Viewed by 123 | Submission Open

Keywords: alcohol; ethanol metabolism; ethanol– protein interactions; ethanol– membrane interactions; cardiovascular health and disease

(This special issue belongs to the Section Molecular Medicine)

Cell Adhesion and Migration in the Nervous System

edited by

Igor Jakovčevski

submission deadline 31 Jan 2026 | Viewed by 104 | Submission Open

Keywords: cell adhesion molecules; extracellular matrix; glycans; nervous system regeneration; nervous system development; immune system; neurodegeneration

Pain and Therapy: Molecular Perspectives and Future Directions

edited by

Francesco Scaglione

submission deadline 31 Jan 2026 | Viewed by 99 | Submission Open

Keywords: pain; nociceptive pain; neuropathic pain; neoplastic pain; pain physiology; pain treatment

(This special issue belongs to the Section Molecular Biology)

Sterol Biosynthesis in Organisms

edited by Damjana Rozman and

Cene Skubic

submission deadline 31 Jan 2026 | Viewed by 96 | Submission Open

Keywords: sterol biosynthesis; sterol metabolism; sterol regulation; sterol-related diseases

(This special issue belongs to the Section Cellular Biochemistry)

Pathogenesis and Targeted Therapy of Neurodegenerative Diseases

edited by

Wioletta Rozpędek-Kamińska

submission deadline 31 Jan 2026 | Viewed by 89 | Submission Open

Keywords: neurodegeneration; neurodegenerative diseases; targeted therapy; molecular mechanisms; disease-modifying treatments

(This special issue belongs to the Section Molecular Medicine)

Regulation of Sperm Function and Embryo Development

edited by

Jacob Thundathil

and

John P. Kastelic

submission deadline 31 Jan 2026 | Viewed by 65 | Submission Open

Keywords: sperm; oocyte; embryo; genes; reproductive technologies

(This special issue belongs to the Section Molecular Reproduction)

Angiogenin: From Molecular Mechanisms to Clinical Implications

edited by

Iogann Tolbatov

submission deadline 31 Jan 2026 | Viewed by 30 | Submission Open

Keywords: angiogenin; angiogenesis; neuroprotection; cancer; neurodegeneration; biomarker; therapeutic target

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Antioxidant Effects of Bioactive Compounds

edited by

Katarzyna Dos Santos Szewczyk

submission deadline 5 Feb 2026 | 1 articles | Viewed by 1399 | Submission Open

Keywords: bioactive compounds; polyphenols; oxidative stress; chronic diseases; nutraceuticals

Advances in Cold Therapies: Novel Physical Approaches for Musculoskeletal Repair–Molecular Insights

edited by Fackson Mwale

submission deadline 6 Feb 2026 | Viewed by 150 | Submission Open

Keywords: cold therapy; cryotherapy; cryoablation; musculoskeletal repair; inflammation modulation; regenerative medicine; extracellular matrix; cold shock proteins; tissue regeneration; physical therapy

Mesenchymal Stem Cell-Derived Exosomes in Tissue Repair and Regeneration

edited by

Carl Randall Harrell

and

Crissy Fellabaum

submission deadline 11 Feb 2026 | Viewed by 197 | Submission Open

Keywords: MSC; vesicles; exosomes; tissue repair and regeneration

CD5 and CD6 Immunobiology: Multitask Immunomodulatory Molecules in Infection, Cancer and Autoimmunity

edited by Lozano Francisco and María Velasco-de Andrés

submission deadline 13 Feb 2026 | Viewed by 82 | Submission Open

Keywords: CD5; CD6; T cells; B1a cells; NK cells; immunomodulation; infection; cancer; autoimmunity; immunotherapy

(This special issue belongs to the Section Biological Factors)

Molecular Insights into the Mechanism of Antipsychotic Drugs

edited by Serdar Dursun and

Massimo Tusconi

submission deadline 15 Feb 2026 | 2 articles | Viewed by 9132 | Submission Open

Keywords: psychotropic medications; antipsychotic drugs; schizophrenia; molecular mechanisms

(This special issue belongs to the Section Molecular Biology)

Advances in Antiviral Drug Development

edited by Angel S. Galabov

submission deadline 15 Feb 2026 | Viewed by 150 | Submission Open

Keywords: viral inhibitors; mechanism of action; antiviral tests

(This special issue belongs to the Section Molecular Medicine)

Advances in Various Roles of High-Density Lipoproteins

edited by

Yoshinari Uehara

submission deadline 15 Feb 2026 | Viewed by 79 | Submission Open

Keywords: atherosclerosis; high-density lipoprotein (HDL); HDL functions; apolipoproteins; lipid and glucose metabolism

(This special issue belongs to the Section Lipids)

Recent Advances in Immunotherapy for Mesothelioma

edited by Licun Wu

submission deadline 15 Feb 2026 | Viewed by 63 | Submission Open

Keywords: mesothelioma; immunotherapy; tumor microenvironment; biomarkers; tumor heterogeneity

(This special issue belongs to the Section Molecular Medicine)

Targeting Protein Misfolding: From Alzheimer's Amyloids to Therapeutic Peptides

edited by

Dariusz Stępkowski

submission deadline 16 Feb 2026 | Viewed by 141 | Submission Open

Keywords: amyloidogenesis; amyloidosis; amyloid fibrils; dissolution of amyloid fibrils; beta-sheet breakers; peptide inhibitors; small molecule inhibitors

TRP Channels in Cardiovascular and Inflammatory Disease, 2nd Edition

edited by

Susan D. Brain

and Soraia Katia Pereira Costa

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1584 | Submission Open

Keywords: TRP channels; TRP ligands; biological functions; new drugs; cardiovascular diseases; inflammation

(This special issue belongs to the Section Molecular Medicine)

Evolutionary Genomics of Bacterial Endosymbionts: From Mutualism to Parasitism

edited by

Amit Sinha

submission deadline 20 Feb 2026 | Viewed by 154 | Submission Open

Keywords: host– symbiont coevolution; metabolic pathways; horizontal DNA transfer; phylogenetics

Molecular Mechanisms of Traumatic Brain Injury

edited by Xiang Gao

submission deadline 22 Feb 2026 | Viewed by 167 | Submission Open

Keywords: traumatic brain injury; cell death; neural degeneration/regeneration; genetic modification; neuroprotection

Endocrine Regulation of Reproductive Tissues: From Molecular Mechanisms to Therapies

edited by

Waldemar Grzegorzewski

submission deadline 25 Feb 2026 | Viewed by 98 | Submission Open

Keywords: hormone signaling; reproductive physiology; steroid receptors; infertility; endocrine disruptors; epigenetic regulation; gonadal steroids; hormone-dependent cancers; therapeutic targeting; gametogenesis

(This special issue belongs to the Section Biological Factors)

Role of Oxidative Stress in Vascular Diseases

edited by

Vittoria Cammisotto

and

Valentina Castellani

submission deadline 26 Feb 2026 | Viewed by 157 | Submission Open

Keywords: oxidative stress; vascular disease; endothelial dysfunction; NADPH oxidase/NOX2; platelet activation; autophagy; gut microbiota; inflammation; reactive oxygen species (ROS); cardiovascular risk

Extracellular Vesicles as Natural Nanocarriers: Advances in Cancer, Tissue Regeneration and Skin Health

edited by

Salvatore Panza

submission deadline 26 Feb 2026 | Viewed by 112 | Submission Open

Keywords: extracellular vesicles; natural nanocarriers; drug delivery; cancer therapy; regenerative medicine; skin health; dermocosmetics; tumor microenvironment; bioactive cargo; targeted delivery

Molecular Advances in Wound Healing and Skin Regeneration

edited by

Hiroyuki Ijima

and Muhammad Shafiq

submission deadline 28 Feb 2026 | 2 articles | Viewed by 23336 | Submission Open

Keywords: artificial dressings; electrospun fiber-based wound dressings; artificial skin equivalents; wound healing; instructive biomaterials for in situ skin repair; microneedles for skin therapy; drug delivery systems for wound healing; cell-free approaches for skin repair; stem cell therapy for wound healing; scarless skin repair

(This special issue belongs to the Section Biological Factors)

Cannabinoids in Neurobehavioral Modulation

edited by