Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in p53 Research submission deadline 30 Nov 2025 | 3 articles | Viewed by 8536 | Submission Open
Keywords: p53; small molecules; tumor suppressor; apoptosis; tumor– host interaction; targeted therapies; tumor microenvironment (TME)
(This special issue belongs to the Section Molecular Biology)
Colorectal and Gastric Cancers: Molecular Mechanisms and Potential Biomarkers submission deadline 30 Nov 2025 | 5 articles | Viewed by 7168 | Submission Open
Keywords: colorectal cancer; gastric cancer; molecular mechanism; biomarkers signalling; molecules gastrointestinal; microbiome; artificial intelligence
(This special issue belongs to the Section Molecular Biomarkers)
Molecular Aspects of Female Infertility
edited by
submission deadline 30 Nov 2025 | 5 articles | Viewed by 6777 | Submission Open
Keywords: female infertility; reproduction; ovary; reproductive aging; genetic disorders
(This special issue belongs to the Section Molecular Biology)
Skeletal Muscle in Health, Exercise and Aging
edited by Barbara Munz
submission deadline 30 Nov 2025 | 3 articles | Viewed by 6743 | Submission Open
Keywords: skeletal muscle; molecular mechanisms of exercise adaptation; aging; cachexia; sarcopenia
(This special issue belongs to the Section Molecular Biology)
Microbial Biocontrol and Plant-Microbe Interactions
edited by
submission deadline 30 Nov 2025 | 5 articles | Viewed by 5122 | Submission Open
Keywords: endophytic microbiome for disease management; plant– microbe interactions; plant– insect– pathogen interactions; microbial and plant metabolites against pathogens; pathogen signaling; microbial communities shift for disease prevention; omics approaches; abiotic stress response
(This special issue belongs to the Section Cellular Biochemistry)
The Role of Mechanotransduction in Cellular Biology submission deadline 30 Nov 2025 | 3 articles | Viewed by 3686 | Submission Open
Keywords: cell membrane; cytosol; nuclear membrane; integrin; mechanotransduction; map kinase pathway; ERKs; JNKs; p38/SAPKs; YAP/TAZ; Hippo pathway
(This special issue belongs to the Section Cellular Biochemistry)
New Insights into Neuroimmunology submission deadline 30 Nov 2025 | 1 articles | Viewed by 3123 | Submission Open
Keywords: neuroimmunology (in health and disease); multiple sclerosis (MS); experimental autoimmune encephalomyelitis (EAE); acute disseminated encephalomyelitis (ADEM); neuromyelitis optica spectrum disorders (NMOSD); transverse myelitis; anti-NMDA receptor encephalitis (NMDAR encephalitis); paraneoplastic autoimmune diseases; neurodegenerative diseases with immunological components; Parkinson’ s disease; Alzheimer’ s disease; neuroinfections
(This special issue belongs to the Section Cellular Biochemistry)
Properties and Functions of Endometrial Stromal Cells submission deadline 30 Nov 2025 | 2 articles | Viewed by 2993 | Submission Open
Keywords: endometrium; endometriosis; molecular reproduction; implantation; decidualization; placentation; inflammation; reproductive endocrinology; assisted reproductive technology; molecular reproductive biology
(This special issue belongs to the Section Molecular Reproduction)
Tumor Microenvironment, Immunology and Precision Medicine of Liver Cancer
edited by Lynn Jeanette Savic
submission deadline 30 Nov 2025 | 2 articles | Viewed by 2959 | Submission Open
Keywords: hepatocellular carcinoma; hypoxia; tumor microenvironment; immunometabolic crosstalk; tumor-associated macrophages
(This special issue belongs to the Section Biological Factors)
Mass Spectrometry Imaging in Neuroscience
edited by Nhu Thi Ngoc Phan
submission deadline 30 Nov 2025 | 1 articles | Viewed by 2861 | Submission Open
Keywords: mass spectrometry imaging; secondary ion mass spectrometry (SIMS); matrix-assisted laser desorption/ionization (MALDI); desorption electrospray ionization (DESI); laser ablation– inductively coupled plasma– mass spectrometry imaging (LA-ICP-MSI); multi-isotope imaging mass spectrometry (MIMS); molecular and organelle turnover; brain; neurons; synapses; neuronal stem cells; membrane lipids; synaptic proteins; neural peptides; metabolites; diseases; disorders
(This special issue belongs to the Section Molecular Medicine)
Advances in Cancer and Glycosylation
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 2095 | Submission Open
Keywords: glycosylation; glycobiology; N-glycans; O-glycans; glycosyltransferases; glycosidases
(This special issue belongs to the Section Molecular Medicine)
Calcium Signaling and Transport in Health and Disease: Recent Developments and New Insights
edited by and Brandi M. Wynne
submission deadline 30 Nov 2025 | 1 articles | Viewed by 2074 | Submission Open
Keywords: calcium signaling; calcium transport; calcium channel; calbindin; calcium pump; calcium stores; mitochondrial calcium; store-operated calcium entry; calcium release
(This special issue belongs to the Section Cellular Biochemistry)
Mechanisms of Kidney Injury and Treatment Modalities
edited by Utpal Sen
submission deadline 30 Nov 2025 | 2 articles | Viewed by 2027 | Submission Open
Keywords: acute and chronic kidney injury; autophagy and mitophagy; bioenergetics; mitochondrial damage; and biogenesis; current therapeutic modalities and future strategies; epigenetic DNA methylation; histone modification; and non-coding RNAs and miRNAs; gaseous molecules and signaling pathways; gender differences; aging; and kidney dysfunction; glomerulosclerosis and renovascular remodelling following injury; gut– kidney axis and health; hypertensive; diabetic; and IgA nephropathy; inflammatory vs. reparatory macrophages and renal repair; ischemia and reperfusion injury; matrix protein; metalloproteinases; and their inhibitors; necrosis; necroptosis; apoptosis; pyroptosis; and ferroptosis; renal repair and regeneration
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Cellular and Non-Cellular Treatment of Stroke
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1827 | Submission Open
Keywords: stroke; treatment; therapy; biomolecules; stem cells
(This special issue belongs to the Section Molecular Medicine)
Molecular Advances in Platelet Disease, Thrombosis and Hemostasis
edited by
submission deadline 30 Nov 2025 | 2 articles | Viewed by 1662 | Submission Open
Keywords: platelets; hemostasis and thrombosis; inherited platelet disorders; coagulation; immunothrombosis; miRNA; GPVI; Runx1; antiplatelet therapy
(This special issue belongs to the Section Molecular Biology)
Recent Developments in the Biology of Extracellular or Cell-Free DNA, 2nd Edition
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1522 | Submission Open
Keywords: neutrophil extracellular traps; DNase; toll-like receptor 9; exosomes; autoimmunity
(This special issue belongs to the Section Molecular Biology)
Pluripotent Stem Cell Models of Human Disease
edited by Satish Kumar
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1490 | Submission Open
Keywords: pluripotent stem cells; cellular reprogramming; cellular differentiation; 2D and 3D cell models of human disease; cellular phenotypes; biomarkers; disease gene; multi-omics approaches; genome editing; drug screening and discovery
(This special issue belongs to the Section Cellular Biochemistry)
Biomolecules and Materials from Agro-Industrial Wastes, 2nd Edition submission deadline 30 Nov 2025 | 1 articles | Viewed by 1133 | Submission Open
Keywords: bioactive molecules from discarded plant parts; new extraction methodologies; green solvents; green chemistry; bioenergy; biorefinery; biofibres
(This special issue belongs to the Section Bio-Engineered Materials)
Impact of Exercise Physiology and Diet on Adipokines in Health and Diseases
edited by Aurora Daniele and
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1131 | Submission Open
Keywords: adipose tissue; adiponectin; adiponectin receptors; physical exercise; exercise; health; disease
(This special issue belongs to the Section Biological Factors)
Protein Self-Assembly in Diseases and Function
edited by , Srivastav Ranganathan and Maria del Carmen Fernandez Ramirez
submission deadline 30 Nov 2025 | 1 articles | Viewed by 989 | Submission Open
Keywords: protein folding; protein aggregation; amyloids; biomolecular condensates
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Metabolic Inflammation and Insulin Resistance in Obesity
edited by Bingxian Xie
submission deadline 30 Nov 2025 | 1 articles | Viewed by 402 | Submission Open
Keywords: obesity-linked inflammation; insulin resistance; adipose tissue
(This special issue belongs to the Section Lipids)
New Insights into Cardiometabolic Diseases, 2nd Edition submission deadline 30 Nov 2025 | Viewed by 387 | Submission Open
Keywords: metabolic diseases; hypertension; obesity; type-2 diabetes; vascular diseases; acute vascular events
(This special issue belongs to the Section Molecular Medicine)
Defects in the Transport Mechanism of Membrane Proteins and Related Diseases, 2nd Edition
edited by Daniela Valeria Miniero
submission deadline 30 Nov 2025 | 1 articles | Viewed by 349 | Submission Open
Keywords: function; structure and folding of membrane transport proteins; pathological mutations; mechanism of transport; neurological and metabolic disease; transport of nanoparticles; organelle membranes; cellular function and signaling; bioenergetics; neuroinflammation; nanoformulations for drug targets
(This special issue belongs to the Section Cellular Biochemistry)
Thyroid Cancer: Molecular Mechanisms and Targeted Therapies submission deadline 30 Nov 2025 | Viewed by 299 | Submission Open
Keywords: differentiated thyroid cancer; medullary thyroid cancer; anaplastic thyroid carcinoma; advanced/metastatic thyroid cancer; refractory thyroid cancer; molecular biomarkers; oncogenic signaling pathways; thyroid cytology; targeted therapy; tyrosine kinase inhibitors; immune checkpoint inhibitors; therapeutic strategies; thyroid cancer prognosis; epigenomics in thyroid cancer
(This special issue belongs to the Section Molecular Medicine)
Antioxidant and Anti-Inflammatory Activities of Phytochemicals
edited by and
submission deadline 30 Nov 2025 | Viewed by 232 | Submission Open
Keywords: antioxidants; plant bioactives; inflammation; free radicals
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Advances in Nano-Based Drug Delivery Systems submission deadline 30 Nov 2025 | Viewed by 209 | Submission Open
Keywords: drug delivery system; nanotechnology; nanomedicine; nanocarriers; nanoparticles; nanoformulation; biomolecules
(This special issue belongs to the Section Molecular Medicine)
Genetic Insights into Biological Mechanisms Governing Aging
edited by and Duilio Michele Potenza
submission deadline 30 Nov 2025 | Viewed by 149 | Submission Open
Keywords: aging; genetics; cellular senescence; oxidative stress; inflammation; mitochondrial function
(This special issue belongs to the Section Molecular Genetics)
Advances in Molecular Mechanisms in Chronic Kidney Disease
edited by and María J. Izquierdo
submission deadline 30 Nov 2025 | Viewed by 148 | Submission Open
Keywords: chronic kidney disease; end-stage kidney disease; etiological diagnosis; biomarkers; personalized medicine; humans
(This special issue belongs to the Section Molecular Biomarkers)
New Insight into the Structures and Host Cell Interactions of Emerging Viruses
edited by and
submission deadline 30 Nov 2025 | Viewed by 134 | Submission Open
Keywords: emerging viruses; virus structure; structural biology; Cryo-EM/Cryo-ET/CLEM; virus– host interactions; viral receptor binding and entry; viral assembly; maturation; and egress; immune evasion; molecular dynamics simulation; antiviral targets
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Novel Evidence About Hydrogen Sulfide (H2S)-Donor Molecules as Innovative Therapeutical Tools 2025
edited by
submission deadline 30 Nov 2025 | Viewed by 133 | Submission Open
Keywords: hydrogen sulfide (H2S)-donor; H2S-releasing molecule; H2S-hybrid drug; hydrogen sulfide; therapeutical tool
(This special issue belongs to the Section Chemical Biology)
Molecular Mechanisms of Olfactory and Gustatory System
edited by
submission deadline 30 Nov 2025 | Viewed by 130 | Submission Open
Keywords: olfaction; smell; taste; chemical stimuli; sensation; perception; Volabolome; advanced diagnostic techniques
(This special issue belongs to the Section Molecular Biology)
Current Advances of Metal Complexes for Biomedical Applications submission deadline 30 Nov 2025 | Viewed by 128 | Submission Open
Keywords: metal complexes; metals in medicine; bioinorganic; anti-cancer; antiviral; anti-inflammatory; antioxidant; imaging applications
(This special issue belongs to the Section Chemical Biology)
Acute Kidney Injury and Mitochondrial Involvement
edited by
submission deadline 30 Nov 2025 | Viewed by 99 | Submission Open
Keywords: acute kidney injury; mitochondrial dysfunction; mitochondrial dynamics; mitophagy; biomarkers
(This special issue belongs to the Section Chemical Biology)
New Technologies and Translational Approach for an Early Diagnosis of Bipolar Spectrum and Hyperactive and Novelty Seeking Profiles
edited by , Serdar Dursun and
submission deadline 30 Nov 2025 | Viewed by 97 | Submission Open
Keywords: psychiatry; mental health; bipolar disorders; mood; biomarkers; new technology; BD
Deciphering Biomolecular Multimeric Systems: Computational Advances in Structure, Dynamics, and Function
edited by , Jinping Lei and Hui Wang
submission deadline 30 Nov 2025 | Viewed by 76 | Submission Open
Keywords: molecular glue; molecular simulations; PROTAC; binding affinity; binding mode; MSM; membrane
Cancer Biology: Machine Learning and Bioinformatics
edited by Annalisa Santucci, and
submission deadline 30 Nov 2025 | Viewed by 72 | Submission Open
Keywords: cancer biology; bioinformatics; machine learning; big data
(This special issue belongs to the Section Bioinformatics and Systems Biology)
Multiple Sclerosis Pathogenesis: Bridging Innate and Adaptive Immunity
edited by Jo Anne Stratton, Stephanie Zandee and Simon Thebault
submission deadline 30 Nov 2025 | Viewed by 71 | Submission Open
Keywords: multiple sclerosis; innate– adaptive immune crosstalk; glial biology and complement; cellular immunology; biomarkers
(This special issue belongs to the Section Molecular Medicine)
Advances in Type 2 Diabetes: Molecular Mechanisms and Therapeutic Innovations
edited by Orien L. Tulp
submission deadline 30 Nov 2025 | Viewed by 70 | Submission Open
Keywords: type 2 diabetes (T2DM); insulin resistance; GLUT4; sirtuins; epigenetic expression; nutrition; pharmacotherapeutics
(This special issue belongs to the Section Molecular Medicine)
Recent Advances in Retroviruses and Endogenous Retroviruses (ERVs) in Mammalian Placenta and Beyond 2025 submission deadline 30 Nov 2025 | Viewed by 70 | Submission Open
Keywords: retroviruses; ERVs (endogenous retroviruses); placental diversity; organ development (stem cells); immunoregulation
(This special issue belongs to the Section Biomacromolecules: Nucleic Acids)
Industrial Microorganisms and Enzyme Technologies
edited by
submission deadline 30 Nov 2025 | Viewed by 62 | Submission Open
Keywords: enzyme engineering; enzyme kinetics and optimization; industrial biotechnology; industrial microbiology; microbial metabolism
(This special issue belongs to the Section Enzymology)
Genetic and Epigenetic Basis of Schizophrenia submission deadline 30 Nov 2025 | Viewed by 47 | Submission Open
Keywords: schizophrenia; epigenetics; animal models; methylation; microRNA; gene-environment interactions
(This special issue belongs to the Section Molecular Genetics)
Mitochondrial Dysfunction: Mechanisms and Advances submission deadline 30 Nov 2025 | Viewed by 45 | Submission Open
Keywords: mitochondrial disease; neurological disorders; cancer; targeted therapy
Functional Structures in RNA Viruses
edited by Riccardo Delli Ponti, , and Laura Broglia
submission deadline 30 Nov 2025 | Viewed by 39 | Submission Open
Keywords: RNA secondary structure; RNA viruses; machine learning; SHAPE; protein– RNA interactions
(This special issue belongs to the Section Bioinformatics and Systems Biology)
New Insights into Stem Cell-Derived Exosomes in Human Health and Disease
edited by
submission deadline 30 Nov 2025 | Viewed by 38 | Submission Open
Keywords: stem cells; exosomes; regenerative medicine; diagnostics
(This special issue belongs to the Section Cellular Biochemistry)
Lipid Signaling in Human Disease
edited by Berit Johansen and Felicity Ashcroft
submission deadline 10 Dec 2025 | Viewed by 66 | Submission Open
Keywords: lipid signaling pathways; membrane-derived lipid signaling molecules; inflammation mechanisms; cellular disease mechanisms; phospholipids; phospholipases; glycerophospholipids; sphingolipids
(This special issue belongs to the Section Lipids)
Mechanisms and Kinetics of Interactions of Biomolecules at Interfaces: 2nd Edition submission deadline 15 Dec 2025 | 4 articles | Viewed by 12699 | Submission Open
Keywords: biomolecule adsorption; kinetics of biomolecule adsorption; mechanisms of biomolecule deposition; interactions of biomolecules; techniques for the detection of biomolecules at solid substrates; interactions of proteins with biomolecules/biopolymers; protein and biomolecule systems; protein and biomolecule complexes
(This special issue belongs to the Section Bio-Engineered Materials)
Antibiotic Resistance Mechanisms and Their Potential Solutions
edited by Sung-Pin Tseng, and
submission deadline 15 Dec 2025 | 4 articles | Viewed by 10807 | Submission Open
Keywords: antibiotic resistance; antimicrobial development; molecular mechanism; priority for antibiotics; newly therapeutic approach
(This special issue belongs to the Section Molecular Biology)
Role of Neuroactive Steroids in Health and Disease: 2nd Edition submission deadline 15 Dec 2025 | 5 articles | Viewed by 7901 | Submission Open
Keywords: neurosteroids; neurodegenerative disorders; psychiatric disorders; physiological effects
(This special issue belongs to the Section Molecular Biology)
Role of TRAF in Regulating Inflammation and Cell Survival
edited by Ali Abdul-Sater
submission deadline 15 Dec 2025 | 2 articles | Viewed by 4169 | Submission Open
Keywords: TRAF; inflammation; inflammasome; TNFRs; apoptosis; cellular survival
(This special issue belongs to the Section Biological Factors)
New Insights into Cardiovascular Immunology
edited by Susanne Sattler, Pilar Martín and Stephen Malin
submission deadline 15 Dec 2025 | 1 articles | Viewed by 3975 | Submission Open
Keywords: inflammation; autoimmunity; atherosclerosis; myocarditis; heart failure
(This special issue belongs to the Section Molecular Medicine)
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