Multiple Sclerosis Pathogenesis: Bridging Innate and Adaptive Immunity
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: 30 November 2025
Special Issue Editors
Interests: neuroinflammation; CSF inflammation; neuro-immune interactions; CSF barrier cells; meninges; ependyma; mouse models; in vitro assays; single-cell technologies
Interests: multiple sclerosis; neuroscience
Special Issue Information
Dear Colleagues,
Multiple sclerosis (MS) is increasingly recognized as a disorder in which innate and adaptive immune mechanisms converge to drive central nervous system injury and repair. Bridging these traditionally distinct domains is critical to advancing mechanistic understanding and therapeutic innovation. Recent insights into the roles of microglia, astrocytes, complement activation, and ependymal cell dysfunction reveal complex interactions between resident CNS cells and peripheral immune effectors, including B cells and T cells shaped by latent Epstein–Barr virus infection. Meanwhile, advances in cellular immunology and biomarker discovery offer new windows into these dynamic processes, with implications for diagnosis, prognosis, and targeted intervention. This special series brings together interdisciplinary contributions that span glial biology, complement and ependymal cell research, viral immunology, and biomarker translation, aiming to foster a more integrated view of MS pathogenesis and progression.
Dr. Jo Anne Stratton
Dr. Stephanie Zandee
Dr. Simon Thebault
Guest Editors
Manuscript Submission Information
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Keywords
- multiple sclerosis
- innate–adaptive immune crosstalk
- glial biology and complement
- cellular immunology
- biomarkers
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