Mitochondrial Dysfunction: Mechanisms and Advances
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: 30 November 2025 | Viewed by 9
Special Issue Editor
Interests: PARP; hypoxia; tumor microenvironment; PARP inhibitor; mitochondrial diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mitochondria, due to their biochemical properties and their intricate networks of information processing, play a key role in various aspects of health regulation and pathology progression. The main mitochondrial functions such as respiratory coupling, fatty acid oxidation, and mitochondrial dynamic processes have been associated with cancer, neurological disorders, and metabolic diseases. A large group of human diseases, called mitochondrial diseases, such as Leigh Syndrome and MELAS, are myopathies caused exclusively by mutations in the mitochondrial genome or in those nuclear genes with essential functions in the electron transport chain. Therefore, the potential value of mitochondria as therapeutic targets has led to the clinical development of a wide range of chemical inhibitors targeting several proteins working on mitochondrial dysfunction. However, the mechanism is much more complex and the biology of mitochondrial regulator enzyme inhibition is still far from fully understood.
This Special Issue welcomes both original research manuscripts, as well as reviews, focusing on the current state of mitochondrial pathology strategies and on potential advances.
Dr. Jose Manuel Rodriguez-Vargas
Guest Editor
Manuscript Submission Information
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Keywords
- mitochondrial disease
- neurological disorders
- cancer
- targeted therapy
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