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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms and Signaling Pathways in Autoimmune Diseases

edited by

Daniele Saverino

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2136 | Submission Open

Keywords: autoimmune diseases; molecular mechanisms; signaling pathways; therapeutic targets; biomarkers

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Anti-Tumor Metal Complexes and Drug Delivery Systems: 2nd Edition

edited by Jasmina Dimitrić Marković,

Goran Kaluđerović

and

Dušan Dimić

submission deadline 30 Apr 2026 | 1 articles | Viewed by 2092 | Submission Open

Keywords: transition metal complexes; synthesis; structural characterization; biological activity; in silico methods; drug delivery

Food, Microbe, Viral and Parasite-Derived Antibodies in Autoimmune and Chronic Diseases

edited by

Phaedra Eleftheriou

submission deadline 30 Apr 2026 | 1 articles | Viewed by 2047 | Submission Open

Keywords: food antigens; antigens; auto-antigens; antibodies; auto-antibodies; auto-immune diseases; chronic diseases; microbes; bacteria; fungi; virus; parasites; cross-reaction; infection; chronic diseases

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Advances in Antimicrobial Peptides (AMPs)

edited by

Andrea Bosso

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1844 | Submission Open

Keywords: antimicrobial peptides (AMPs); host defense peptides (HDPs); peptidomimetics; antimicrobial resistance (AMR); membrane interaction; cryptides; immunomodulation; peptide design and synthesis; biofilm inhibition; drug delivery systems

Homocysteine and H₂S in Health and Disease, 2nd Edition

edited by

Anton Hermann

and

Guzel F. Sitdikova

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1675 | Submission Open

Keywords: homocysteine (Hcy); hydrogen sulfide (H2S); oxidative stress; inflammation

(This special issue belongs to the Section Chemical Biology)

Metallic Nanoparticles: Biosynthesis and Therapeutic Potential

edited by

Sónia Gonçalves

and

Isabelle Michaud-Soret

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1603 | Submission Open

Keywords: silver nanoparticle; antibacterial agent; green synthesis; therapeutics

(This special issue belongs to the Section Biological Factors)

Multiple Myeloma: From Pathophysiology to Novel Therapeutic Approaches

edited by

Cirino Botta

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1032 | Submission Open

Keywords: multiple myeloma; tumor immunology; MGUS; sMM

The Role and Metabolism of Metals in Cancer

edited by

Anna Martina Battaglia

submission deadline 30 Apr 2026 | 1 articles | Viewed by 943 | Submission Open

Keywords: metals; cancer; cancer metabolism

(This special issue belongs to the Section Chemical Biology)

Metal-Based Complexes in Medicine: From Therapeutics to Diagnostics and Theranostics

edited by

Iogann Tolbatov

and

Andrea Melchior

submission deadline 30 Apr 2026 | 1 articles | Viewed by 806 | Submission Open

Keywords: anticancer metal complexes; antitumor metallodrugs; antimicrobial agents; antiviral metallodrugs; medicinal inorganic chemistry; bioinorganic chemistry; computational design; molecular dynamics; docking; spectroscopic methods; NMR; mechanistic studies; rational drug development; synthesis; biological evaluation; drug delivery; experimental; in vitro; in vivo; theranostics; medicinal imaging

Phytochemicals: Bioactivity in Disease Prevention, Anti-Inflammation, and Animal/Human Health

edited by

Jayasimha Rayalu Daddam

and

Kotha Peddanna

submission deadline 30 Apr 2026 | Viewed by 781 | Submission Open

Keywords: phytochemicals; anti-inflammatory; metabolic health; oxidative stress; gut microbiome; nutrigenomics; animal health; human health; systems biology; AI/ML

(This special issue belongs to the Section Molecular Medicine)

Lipids and Lipoproteins in Human Health and Disease

edited by

Menno Hoekstra

submission deadline 30 Apr 2026 | 1 articles | Viewed by 648 | Submission Open

Keywords: lipid; lipoprotein; lipophilic molecules

(This special issue belongs to the Section Biological Factors)

Biomolecular Sciences and Precision Medicine in Vascular Disease

edited by

Raffaele Serra

submission deadline 30 Apr 2026 | 1 articles | Viewed by 630 | Submission Open

Keywords: precision medicine; vascular disease; vascular surgery

(This special issue belongs to the Section Molecular Medicine)

Metabolic Syndrome and Type 2 Diabetes: From Molecular Pathogenesis to Novel Therapies

edited by

Srinivas Nammi

submission deadline 30 Apr 2026 | Viewed by 369 | Submission Open

Keywords: metabolic syndrome; type 2 diabetes; insulin resistance; molecular pathogenesis; novel therapies

(This special issue belongs to the Section Molecular Medicine)

Omics in Entomology: Unraveling the Molecular Mechanisms of Insects

edited by

Kaio Cesar Chaboli Alevi

submission deadline 30 Apr 2026 | Viewed by 301 | Submission Open

Keywords: entomology; medical entomology; forensic entomology; agricultural entomology; omics

(This special issue belongs to the Section Molecular Genetics)

Advances in S-Triazine-Based Therapeutics: From Antimicrobials to Neurodegenerative Disease Modulators

edited by

Danuta Drozdowska

submission deadline 30 Apr 2026 | Viewed by 257 | Submission Open

Keywords: 1; 3; 5-triazine; s-triazine; biological activity; drug discovery; antibacterial agent; antifungal agent; anticancer activity; antiviral agents; antimalarial activity; anti-Alzheimer’ s activity; anti-Alzheimer’ s agents; cholinesterase inhibitors; BACE1 inhibitors; anti-neurodegenerative effects; anti-inflammatory activity; molecular mechanisms of s-triazine activity

(This special issue belongs to the Section Chemical Biology)

Psilocybe Mushrooms Constituents—Therapeutic Implications

edited by

Andrea Bugarcic

and Janet Schloss

submission deadline 30 Apr 2026 | Viewed by 244 | Submission Open

Keywords: Psilocybe mushrooms; psilocybin; pre-clinical research; neurodegeneration

Cell Death and Clearance

edited by

Ivan Poon

and Jascinta Santavanond

submission deadline 30 Apr 2026 | Viewed by 206 | Submission Open

Keywords: cell death; apoptosis; efferocytosis; cell clearance

(This special issue belongs to the Section Molecular Medicine)

Enzyme Inhibitors as Novel Medicinal Agents: From Current to Future Applications

edited by George Kokotos and

Christiana Mantzourani

submission deadline 30 Apr 2026 | Viewed by 187 | Submission Open

Keywords: design and synthesis of inhibitors; structure-activity relationship studies; inhibitors of histone deacetylases; inhibitors of proteases; inhibitors of kinases; inhibitors of lipid hydrolyzing enzymes; inhibitors of viral enzymes

(This special issue belongs to the Section Molecular Medicine)

Recent Advances in Structure-Based Inhibitor/Drug Design

edited by

Guoping Zhou

submission deadline 30 Apr 2026 | Viewed by 136 | Submission Open

Keywords: biomolecular interactions; structures and functions of biomolecules; nuclear magnetic resonance (NMR); X-ray crystallography; bioinformatics; structural studies using Artificial Intelligence (AI); machine learning (ML); deep learning (DL); molecular dynamics simulation (MDS)

Functional Structures in RNA Viruses

edited by Riccardo Delli Ponti,

Gian Gaetano Tartaglia

Andrea Vandelli

and Laura Broglia

submission deadline 30 Apr 2026 | Viewed by 133 | Submission Open

Keywords: RNA secondary structure; RNA viruses; machine learning; SHAPE; protein– RNA interactions

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Insights into G-Quadruplexes and I-Motifs: Structure, Dynamics and Function

edited by

Keiko Kawauchi

and Tamaki Endoh

submission deadline 30 Apr 2026 | Viewed by 119 | Submission Open

Keywords: non-B DNA structures; G-quadruplex; i-motif; nucleic acid structural dynamics; gene regulation; bioinformatics; ligand development; therapeutic applications

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Molecular Mechanisms and Current Treatment Strategy of Sarcomas

edited by

Katia Scotlandi

and

Caterina Mancarella

submission deadline 30 Apr 2026 | Viewed by 118 | Submission Open

Keywords: sarcoma; therapeutic vulnerabilities; preclinical models; molecular target

(This special issue belongs to the Section Molecular Medicine)

Glycomics in Health, Aging and Disease

edited by

Domenico Garozzo

submission deadline 30 Apr 2026 | Viewed by 118 | Submission Open

Keywords: glycome; glycobiology; glycochemistry; glycans; glycoconjugates

(This special issue belongs to the Section Cellular Biochemistry)

The Immune Response to Severe Trauma

edited by

Jon Hazeldine

and David N Naumann

submission deadline 30 Apr 2026 | Viewed by 117 | Submission Open

Keywords: trauma-induced immune response; systemic inflammation; immune suppression; immune dysregulation; critical care

(This special issue belongs to the Section Molecular Medicine)

Molecular Factors Involved in Healthy and Diseased States of Skeletal Muscle: Overview and Perspectives

edited by

Virginia Tancredi

Roberto Bonanni

and

Ida Cariati

submission deadline 30 Apr 2026 | Viewed by 111 | Submission Open

Keywords: skeletal muscle; ageing; muscle physiology; muscle-multiorgan crosstalk; muscle health; muscle atrophy; molecular factors; sedentariness; exercise

(This special issue belongs to the Section Biological Factors)

Molecular Mechanisms, Pathogenesis, and Treatment of Cardiovascular Diseases

edited by

Mahavir Singh

and

Zsuzsa Bagoly

submission deadline 30 Apr 2026 | Viewed by 84 | Submission Open

Keywords: cardiovascular diseases; molecular pathogenesis; genomics and metabolomics; AI/ML diagnostics; precision medicine; translational research

(This special issue belongs to the Section Molecular Medicine)

Application of Spectral Analysis in Disease Diagnosis and Treatment

edited by

Entesar Al-Hetlani

and

Igor Lednev

submission deadline 30 Apr 2026 | Viewed by 83 | Submission Open

Keywords: molecular spectroscopy; mass spectrometry; medical diagnostics; disease treatment/treatment monitoring; lipidomics/proteomics/metabolomics; biofluids; machine learning

(This special issue belongs to the Section Molecular Medicine)

Therapeutic Applications of Extracellular Vesicles in Inflammation and Immunoregulation

edited by

Ahmed Abdal Dayem

submission deadline 30 Apr 2026 | Viewed by 81 | Submission Open

Keywords: extracellular vesicles; inflammatory diseases; immunomodulation; regenerative therapy; therapeutic applications

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Signal Transduction and Pathway Regulation in Cancer

edited by

Carmen Cristina Diaconu

submission deadline 30 Apr 2026 | Viewed by 81 | Submission Open

Keywords: signal transduction; pathway modulation; targeted treatment strategies; cancer treatment; drug resistance; cancer diagnosis; cancer prognosis

(This special issue belongs to the Section Molecular Biology)

Gas Chromatography–Mass Spectrometry as a Versatile Tool for Plant Metabolomics

edited by

Andrej Frolov

and

Tatiana E. Bilova

submission deadline 30 Apr 2026 | Viewed by 79 | Submission Open

Keywords: GC-MS; plant metabolomics; biologically active metabolites; metabolomics-assisted breeding; stress response; multi-omics integration

(This special issue belongs to the Section Molecular Biology)

Pathophysiological Insights into Congenital Myasthenic Syndromes

edited by Xin-Ming Shen, Kinji Ohno and Duygu Selcen

submission deadline 30 Apr 2026 | Viewed by 79 | Submission Open

Keywords: neuromuscular junction; neurotransmission; developmental biology; myasthenia; congenital myasthenic syndrome; human genetics; variant; mutation; animal model

(This special issue belongs to the Section Molecular Medicine)

Microbiome–Gut–Brain Axis in Neurodevelopmental Disorders

edited by Katerina Karaivazoglou and

Konstantinos Kotsis

submission deadline 30 Apr 2026 | Viewed by 77 | Submission Open

Keywords: microbiome– gut– brain axis; neurodevelopmental disorders; autism; schizophrenia; intestinal dysbiosis

(This special issue belongs to the Section Molecular Biology)

Tumor Biomarkers and Precision Therapy: Epigenetic, Immune, and Proteomic Strategies

edited by

Ximena Maria Muresan

and

Ioana Ecaterina Pralea

submission deadline 30 Apr 2026 | Viewed by 72 | Submission Open

Keywords: tumors; biomarkers; epigenetics; immune targets; proteomics; mass-spectrometry based proteomics; targeted therapy

(This special issue belongs to the Section Molecular Biomarkers)

Advances in the Molecular Mechanisms of Inflammatory Arthritis and Inflammation-Related Bone Changes: 2nd Edition

edited by

Carlo Perricone

submission deadline 30 Apr 2026 | Viewed by 71 | Submission Open

Keywords: inflammatory arthritis; molecular mechanisms; bone changes; osteoimmunology; autoimmunity

(This special issue belongs to the Section Molecular Medicine)

The Role of Scavenger Receptors in Health and Disease

edited by

Laura Cristina Ceafalan

and Mihail E. Hinescu

submission deadline 30 Apr 2026 | Viewed by 70 | Submission Open

Keywords: scavenger receptor; CD36; lipid scavenger; cell-to-matrix adhesion; metastasis; neoangiogenesis; biomarker

(This special issue belongs to the Section Biological Factors)

AI-Driven Approaches to Neurodegeneration: From Disease Models to Therapeutic Strategies

edited by

Thomas R. Caulfield

, Jianfu Li and Naeyma N. Islam

submission deadline 30 Apr 2026 | Viewed by 68 | Submission Open

Keywords: artificial intelligence (AI); neurodegeneration; disease modeling; therapeutic discovery; machine learning in biomedicine

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Structural and Functional Insights into Metalloantibiotics

edited by

Li-June Ming

submission deadline 30 Apr 2026 | Viewed by 55 | Submission Open

Keywords: metal ion; biomolecules; enzyme; antimicrobial resistance

(This special issue belongs to the Section Enzymology)

Molecular Genetics and Molecular Diagnosis in Precision Oncology

edited by Andrea Ferreira-Gonzalez

submission deadline 30 Apr 2026 | Viewed by 50 | Submission Open

Keywords: cancer; genetics; molecular therapy; immunotherapy; molecular genetics; molecular diagnostics; NGS; liquid biopsy

(This special issue belongs to the Section Molecular Genetics)

Multidrug-Resistant Microorganisms: Overcoming the Challenges in Antibiotic Treatment

edited by Eleni E. Mylona and

Dimitris Kounatidis

submission deadline 30 Apr 2026 | Viewed by 39 | Submission Open

Keywords: multidrug-resistant; antibiotic treatment; MDR pathogens; therapeutic strategies

Molecular Circuits of Cell Fate Reprogramming and Plasticity

edited by

Myon Hee Lee

submission deadline 30 Apr 2026 | Viewed by 27 | Submission Open

Keywords: stem cell self-renewal and differentiation; pluripotency networks; cell fate reprogramming (dedifferentiation and trans-differentiation); cellular plasticity; transcriptional; post-transcriptional; and epigenetic regulation; chemical reprogramming; regenerative medicine; technologies for cell fate reprogramming; model organisms; disease models

(This special issue belongs to the Section Cellular Biochemistry)

Pathogenesis, Diagnosis, and Treatment of Diabetic Kidney Disease

edited by

Carlos Rosado

submission deadline 1 May 2026 | Viewed by 139 | Submission Open

Keywords: diabetic kidney disease; pathogenesis; novel biomarkers; metabolic memory; SGLT2 inhibitors; fibrotic pathways; epigenetic modification; multi-target pharmacotherapy

Transcription Factors in Hematopoiesis and Immunity: From Development to Therapeutic Targeting

edited by Amiya Kumar Patra

submission deadline 3 May 2026 | 2 articles | Viewed by 1848 | Submission Open

Keywords: transcription factors; immune regulation; epigenetics; cytokines and chemokines; molecular interaction; immunodeficiency; allergy; leukemia and lymphoma; small molecule inhibitors; hematopoietic disorders

(This special issue belongs to the Section Molecular Biology)

Pancreatic Cancer: From Molecular Mechanisms to Therapeutic Strategies

edited by

Harrys Kishore Charles Jacob

and

John Lalith Charles Richard

submission deadline 10 May 2026 | Viewed by 91 | Submission Open

Keywords: pancreatic cancer; multi-omics; epigenetics; single-cell transcriptomics; artificial intelligence; therapeutics

The Role of Vascular Dysfunction in Neuronal Degeneration and Cognitive Impairment (2nd Edition)

edited by

David Lominadze

submission deadline 15 May 2026 | 7 articles | Viewed by 17403 | Submission Open

Keywords: blood cells; plasma components; vascular wall components; neurovascular unit; neuroinflammation; cognitive decline

(This special issue belongs to the Section Molecular Biology)

Protein Self-Assembly in Diseases and Function

edited by

Anoop Arunagiri

, Srivastav Ranganathan and Maria del Carmen Fernandez Ramirez

submission deadline 15 May 2026 | 1 articles | Viewed by 1736 | Submission Open

Keywords: protein folding; protein aggregation; amyloids; biomolecular condensates

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Cancer Biology: Machine Learning and Bioinformatics

edited by Annalisa Santucci,

Ottavia Spiga

and

Anna Visibelli

submission deadline 15 May 2026 | 1 articles | Viewed by 646 | Submission Open

Keywords: cancer biology; bioinformatics; machine learning; big data

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Polysaccharides for Material Applications: From Plastics to Drug Carrier and Delivery Systems

edited by

Nicolas Joly

Patrick M. Martin

and

Vincent Sol

submission deadline 15 May 2026 | Viewed by 112 | Submission Open

Keywords: chemo/enzymatic modification; materials; plastics; composites; food applications; membranes; biomedical applications; biomaterials; drug delivery systems; nano carriers

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Ovarian Cancer and Breast Cancer: Molecular Mechanisms, and Therapeutic Targets

edited by

Emily Golden

and

Priya Gopal Krishnan

submission deadline 15 May 2026 | Viewed by 103 | Submission Open

Keywords: breast neoplasms; ovarian neoplasms; cancers; molecular subtyping; genomic instability; tumour heterogeneity; precision medicine; targeted therapy; PARP inhibitors; immunotherapy; chemotherapy resistance; triple negative breast neoplasms; HER2-positive breast cancer; high-grade serous ovarian cancer; low-grade serous ovarian cancer; rare cancer subtypes; next-generation sequencing

Neutrophils in Health and Disease: From Molecular Mechanisms to Therapies

edited by

Xin Xu

and

Lawrence Rasmussen

submission deadline 16 May 2026 | Viewed by 110 | Submission Open

Keywords: neutrophils; immune regulation; inflammation; infectious diseases; autoimmune disease; tumor

(This special issue belongs to the Section Biological Factors)

Industrial Microorganisms and Enzyme Technologies

edited by