GPCRs: Structure, Biology and Potential Applications
This special issue belongs to the section "Cellular Biochemistry".
Special Issue Information
Dear Colleagues,
The more than 800 human GPCRs impact almost all aspects of physiology and represent the largest family of drug targets. The recent revolution in the structural biology of GPCRs in complexes with agonists, antagonists, allosteric modulators, and intracellular signaling partners has been crucial in determining a general mechanism of GPCR activation and has provided structural frameworks for the rational design of pharmacological GPCR regulators.
For this Special Issue, we would like to invite review articles by leading experts on the structure–function relationship of select GPCRs and GPCR subfamilies, GPCRs as therapeutics, and the coupling of GPCRs to G proteins, arrestins, and GRKs.
Prof. Dr. Karsten Melcher
Guest Editor
Manuscript Submission Information
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Keywords
- GPCR
- medicinal chemistry
- G proteins
- arrestins
- GPCR kinases
- X-ray crystallography
- Cryo-EM
- computational drug discovery
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Published Papers
Biomolecules - ISSN 2218-273X