Biogenic Polyamines and Related Metabolites

Dear Colleagues,

Biogenic polyamines spermine, spermidine, and their precursor putrescine are low molecular weight compounds that are present in all types of organisms. Cells maintain spermine and spermidine levels through tight control of expression of polyamine-metabolizing enzymes at transcriptional, translational, and post-translational levels, as well as by regulation of polyamine influx. In recent decades, numerous examples have shown that dysregulation of polyamine metabolism is associated and, in many cases, contributes to the development of various types of cancer, autoimmune, and metabolic diseases. In addition, polyamines are crucial for the replication/growth of viruses, bacteria, and parasites. The polyamine metabolism is considered as one of the possible targets for the treatment of some of the abovementioned diseases. This Special Issue will cover different aspects of polyamine metabolism, the roles of spermine and spermidine in cell growth and differentiation, and in the development of the diseases. In addition, we welcome any papers on the function of other metabolic systems, including S-adenosylmethionine and transmethylation, urea cycle, glutamate/glutamine, and proline metabolism having a link, or being tightly related to biogenic polyamines.

Dr. Alexander Ivanov
Prof. Alex Khomutov
Guest Editors

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