Role of Postbiotics on Health Maintenance and Recovery

Dear Colleagues,

Over the last few years, the interactions between the host and resident microorganisms have represented one of the most studied research areas; indeed, by studying these mechanisms, researchers are trying to understand the onset of disease and how it progresses. We know that our resident microbiota interacts with our metabolic pathways by producing metabolites, commonly named postbiotics. In this way, microorganisms can modulate the immune response, defend the host from pathogens, and regulate other functions such as the absorption of nutrients, endocrine functions, etc. 

One of the most studied interactions is the gut–brain axis. The metabolites produced by the gut microbiota affect the nervous system. However, similar relationships are arising in other body systems between the microbiota and organs.

All of these positive effects are possible under eubiosis, but things change during dysbiosis. In this condition, the status of the microbiota is altered and therefore so is the production of metabolites, which leads to an increase in the inflammation of body tissues.

Probiotics, beneficial microbes commercially available, can modify and regulate the resident microbiota thanks to several byproducts (i.e., salivaricins, lantibiotics, SCFAs, etc.), improving the host's health status.

With the Special Issue “Role of Postbiotics on Health Maintenance and Recovery”, we aim to focus on the current state of the art and highlight recent discoveries on the role of such metabolites derived from resident microbiota and supplemented probiotics.

Prof. Dr. Luigi Santacroce
Guest Editor

Marica Colella
Guest Editor Assistant

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