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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Mechanisms and Management of Chronic Pain: Nociceptive, Neuropathic, and Nociplastic Perspectives

edited by

César Fernández-de-las-Peñas

submission deadline 1 Jul 2026 | Viewed by 40 | Submission Open

Keywords: pain; nociplastic; sensitization; neuropathic; mechanisms; treatment; classification

(This special issue belongs to the Section Molecular and Translational Medicine)

Exploring Human Diseases Through Genomic and Genetic Analyses

edited by Fernando Regateiro and

Henriqueta Silva

submission deadline 15 Jul 2026 | 4 articles | Viewed by 5228 | Submission Open

Keywords: genomic and genetic analyses; genomic medicine; personalized medicine; technologies and testing methods; complex diseases; monogenic diseases; pharmacogenomics

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

The Role of Iron in Human Diseases

edited by Margherita Correnti

submission deadline 15 Jul 2026 | 3 articles | Viewed by 4165 | Submission Open

Keywords: iron metabolism; iron dysregulation; diseases; iron deficiency; iron overload

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Animal Models of Human Pathology: Revision, Relevance and Refinements (4th Edition)

edited by

Martina Perše

submission deadline 15 Jul 2026 | 4 articles | Viewed by 1774 | Submission Open

Keywords: animal models; biomarkers; human disease; pathology; translation; mechanisms; nephrology; gastroenterology; urology; neuroscience; cancer; experimental design; reproducibility; refinements

(This special issue belongs to the Section Molecular and Translational Medicine)

Photodynamic Therapy (4th Edition)

edited by

Stefano Bacci

submission deadline 15 Jul 2026 | Viewed by 320 | Submission Open

Keywords: antimicrobial photodynamic treatment; chronic wounds; inflammatory dermatoses; photobiology photochemistry; photochemotherapy; photosensitizing agents; skin cancer; oral mucosa

(This special issue belongs to the Section Immunology and Immunotherapy)

Extracellular Matrix in Health and Disorders (2nd Edition)

edited by

Caterina Licini

submission deadline 15 Jul 2026 | Viewed by 182 | Submission Open

Keywords: ECM; connective tissue; healthy tissues; pathological tissues; imaging; drug targets; markers; dermis; bone; tendon

(This special issue belongs to the Section Molecular and Translational Medicine)

Advancing Pharmacogenetics and Pharmacogenomics in Pre-Clinical Research: Unveiling New Avenues for Precision Medicine

edited by

Shengying Qin

and

Cong Huai

submission deadline 30 Jul 2026 | 1 articles | Viewed by 862 | Submission Open

Keywords: pharmacogenetics; pharmacogenomics; precision medicine; individualized medicine

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Immune Checkpoint Blockade and Beyond: Next-Generation Cancer Immunotherapies

edited by Wenxuan Zhang

submission deadline 30 Jul 2026 | Viewed by 41 | Submission Open

Keywords: immune checkpoint blockade; cancer immunotherapy; tumor microenvironment; immune resistance; PD-1/PD-L1; CTLA-4; combinatorial therapy; immunometabolism; biomarkers; translational oncology

(This special issue belongs to the Section Immunology and Immunotherapy)

Ovarian Physiology and Reproduction

edited by Atefeh Najafi

submission deadline 31 Jul 2026 | 6 articles | Viewed by 17332 | Submission Open

Keywords: ovarian physiology; female fertility; folliculogenesis; oocyte; hormonal regulation; endocrine disruptors; ovarian aging; genetic modifications; environmental factors and female fertility; female reproductive health and disorders

(This special issue belongs to the Section Molecular and Translational Medicine)

Biological Therapies for Asthma: Targeting Type 1 and Type 2 Inflammation

edited by Mohammad Irshad Reza and Nilesh Sudhakar Ambhore

submission deadline 31 Jul 2026 | 2 articles | Viewed by 11038 | Submission Open

Keywords: asthma endotypes; type 1 inflammation; type 2 inflammation; biological therapies for asthma; non-type 2 asthma; cytokine pathways in asthma; precision medicine in asthma; inflammatory biomarkers in asthma; Th1/Th2 immune responses

(This special issue belongs to the Section Molecular and Translational Medicine)

Animal Models of Neurological Disorders: Where Are We Now? (3rd Edition)

edited by

Marc Ekker

submission deadline 31 Jul 2026 | 3 articles | Viewed by 6398 | Submission Open

Keywords: animal model of neurological disorders; Parkinson’ s disease; Alzheimer’ s disease; epilepsy; seizures; Huntington’ s disease; schizophrenia

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Zebrafish Models for Development and Disease—5th Edition

edited by

James A. Marrs

submission deadline 31 Jul 2026 | 1 articles | Viewed by 3376 | Submission Open

Keywords: disease model; drug screening model; teratogen screening; toxicological screening; neuroscience; behavior; developmental biology

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Extracellular Vesicles in Therapeutics

edited by

Mangesh D. Hade

and

Akil Akhtar

submission deadline 31 Jul 2026 | 1 articles | Viewed by 3103 | Submission Open

Keywords: extracellular vesicles (EVs); exosomes; regenerative medicine; immunotherapy; nanocarriers; biomarkers

(This special issue belongs to the Section Immunology and Immunotherapy)

Diagnosis, Pathogenesis and Treatment of CNS Tumors (2nd Edition)

edited by

Dimitrios Kanakis

submission deadline 31 Jul 2026 | 3 articles | Viewed by 2119 | Submission Open

Keywords: CNS tumors; diagnosis; pathogenesis; treatment; prognosis; molecular markers

(This special issue belongs to the Section Molecular and Translational Medicine)

State-of-the-Art Molecular and Translational Medicine in Japan

edited by

Takemichi Fukasawa

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1750 | Submission Open

Keywords: molecular and translational research; targeting inflammatory cytokines; targeted drugs; skin diseases; basic mechanisms; novel therapies

(This special issue belongs to the Section Molecular and Translational Medicine)

Platelets in Human Health and Diseases

edited by Joanna Sikora

submission deadline 31 Jul 2026 | 2 articles | Viewed by 1058 | Submission Open

Keywords: platelet; hemostasis; thrombosis; antiplatelet drugs; inflammation; cancer; cardiovascular diseases

(This special issue belongs to the Section Cell Biology and Pathology)

Clinical Advances in Hepatocellular Carcinoma

edited by Mohamed A. Abd El Aziz

submission deadline 31 Jul 2026 | 1 articles | Viewed by 371 | Submission Open

Keywords: hepatocellular cancer; liver cirrhosis; chemotherapy; immunotherapy; radiofrequency ablation; microwave ablation

(This special issue belongs to the Section Cancer Biology and Oncology)

Unleashing the Power of Innovative Nanoparticles for Enhanced Radiation Therapy

edited by Fangchao Jiang

submission deadline 31 Jul 2026 | Viewed by 326 | Submission Open

Keywords: nanomedicine; drug delivery; radiation therapy; nanotheranostics; nanoparticles; cancer treatment; biomaterial

(This special issue belongs to the Section Nanomedicine and Nanobiology)

Novel Strategies for Oncogene-Addicted Lung Cancers: Not Rare Anymore

edited by

Carminia Maria Della Corte

submission deadline 31 Jul 2026 | Viewed by 237 | Submission Open

Keywords: target therapy; EMT; biomarkers; cancer mutations; preclinical models

(This special issue belongs to the Section Cancer Biology and Oncology)

Advances in the Diagnosis and Interventional Management of Peripheral Artery Disease: Emerging Technologies, Evidence, and Clinical Pathways

edited by Ioannis Skalidis

submission deadline 31 Jul 2026 | 1 articles | Viewed by 215 | Submission Open

Keywords: peripheral artery disease; peripheral interventions; atherosclerosis; angioplasty; diagnosis and treatment

(This special issue belongs to the Section Molecular and Translational Medicine)

RNA Therapy in Cancer Treatment: From Design to Clinical Translation

edited by Zhouxiao Li

submission deadline 31 Jul 2026 | Viewed by 144 | Submission Open

Keywords: mRNA vaccines; RNA interference (siRNA/miRNA); non-coding RNA therapeutics; lipid nanoparticles (LNPs); tumor microenvironment; neoantigen targeting; combination immunotherapy; clinical translation

(This special issue belongs to the Section Gene and Cell Therapy)

Biomedical Applications of Microfluidics

edited by

Surjendu Maity

submission deadline 31 Jul 2026 | Viewed by 138 | Submission Open

Keywords: microfluidics; organ-on-a-chip; lab-on-a-chip; disease modeling; regenerative medicine; cancer immunotherapy; biosensors; mathematical modeling; AI/ML; realtime sensing

(This special issue belongs to the Section Biomedical Engineering and Materials)

Dopamine and Androgen Receptor Signaling: Novel Insights in Cancer Biology

edited by Srijan Acharya

submission deadline 31 Jul 2026 | Viewed by 132 | Submission Open

Keywords: dopamine signaling; androgen receptor; cancer biology; hormone-sensitive tumors; signal transduction; tumor microenvironment; neurotransmitters in cancer; prostate cancer; breast cancer; targeted therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Skeletal Muscle Ageing: From Molecular Mechanism to Treatment

edited by Can Cui and

Manuela Bozzi

submission deadline 31 Jul 2026 | Viewed by 116 | Submission Open

Keywords: skeletal muscle aging; sarcopenia; muscle regeneration; neuromuscular degeneration; molecular mechanisms of aging; mitochondrial dysfunction; inflammation and aging; therapeutic interventions; exercise and muscle health; musculoskeletal disorders in aging

(This special issue belongs to the Section Molecular and Translational Medicine)

Molecular Research of Chronic Kidney Disease

edited by Jingyuan Xie

submission deadline 31 Jul 2026 | Viewed by 73 | Submission Open

Keywords: chronic kidney disease; molecular mechanisms; biomarker discovery; inflammation; fibrosis; genetic kidney disease; glomerulonephritis; diabetic nephrology

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Cardiac Dysfunction: From Early Detection to Innovative Therapies

edited by

Carla Contaldi

submission deadline 31 Jul 2026 | Viewed by 70 | Submission Open

Keywords: cardiac dysfunction; heart failure; early detection; advanced heart failure; advanced cardiac imaging; biomarkers; innovative therapies; risk stratification; precision medicine

(This special issue belongs to the Section Molecular and Translational Medicine)

Esophageal Cancer: Pathogenesis and Therapeutic Strategies

edited by

Boopathi Subramaniyan

submission deadline 31 Jul 2026 | Viewed by 61 | Submission Open

Keywords: ESCC; EACC; biomarkers; transcription factors; signaling pathways; immune cells; metabolism; animal model; cell lineage and gender

(This special issue belongs to the Section Cancer Biology and Oncology)

Advancing Precision Radiation Oncology in Head and Neck Cancers

edited by

Wing-Keen Yap

submission deadline 31 Jul 2026 | Viewed by 58 | Submission Open

Keywords: precision radiation oncology; head and neck cancers; oncogenetics; genomic biomarkers; radiosensitivity; adaptive radiotherapy; artificial intelligence; immunotherapy integration; proton therapy; deescalation strategies

(This special issue belongs to the Section Cancer Biology and Oncology)

Advanced Single-Cell Sequencing in Diseases

edited by Sedat Kacar

submission deadline 31 Jul 2026 | Viewed by 57 | Submission Open

Keywords: single-cell sequencing; bioinformatics analysis; spatial transcriptomics; cellular heterogeneity; data-driven discovery; disease biology

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Inflammatory Bowel Disease: Pathomechanisms, Diagnostics, and Novel Therapeutic Strategies

edited by

Ziming Zheng

submission deadline 31 Jul 2026 | Viewed by 57 | Submission Open

Keywords: inflammatory bowel disease; Crohn’ s disease; bowel inflammation; targeted therapy

(This special issue belongs to the Section Molecular and Translational Medicine)

Cardiac Arrhythmias and Arrhythmogenic Disorders: Pathomechanisms, Diagnostics and Novel Treatment Options

edited by Michela Casella and

Yari Valeri

submission deadline 31 Jul 2026 | Viewed by 51 | Submission Open

Keywords: arrhythmias; arrhythmogenic disorders; cardiomyopathies; genetics; cardiac MRI; atrial fibrillation; premature ventricular contraction; ventricular tachycardia; catheter ablation

(This special issue belongs to the Section Molecular and Translational Medicine)

Periodontal Disease: From Pathophysiology to Novel Therapeutic Approaches—2nd Edition

edited by

Lu Li

submission deadline 31 Jul 2026 | Viewed by 48 | Submission Open

Keywords: periodontal disease; oral microbiome; dysbiosis; artificial intelligence (AI); personalized therapeutic interventions

(This special issue belongs to the Section Molecular and Translational Medicine)

Extracellular Vesicles for Diagnosis and Therapy of Human Diseases, 2nd Edition

edited by

Zoran Minic

submission deadline 31 Jul 2026 | Viewed by 47 | Submission Open

Keywords: human diseases; extracellular vesicles; biomarkers; diagnosis; prognosis; therapeutic targets; therapeutic applications; EV engineering; physiology; pathology

(This special issue belongs to the Section Molecular and Translational Medicine)

Rewiring Immune Fate: Immunometabolic and Epigenetic Mechanisms in Therapeutic Immunomodulation in Inflammation, Aging, and Cancer

edited by Sandip Ashok Sonar and

Thoihen Heikrujam

submission deadline 31 Jul 2026 | Viewed by 46 | Submission Open

Keywords: immunotherapy; cell therapy; immunometabolism; epigenetic reprogramming; chronic inflammation; immunosenescence; anti-cancer immunity; regeneration of the immune system; system biology of immunometabolism; tumor microenvironment; neuroimmune communication; graft versus host diseases; stromal regulation of structure and function of lymphoid organs

(This special issue belongs to the Section Immunology and Immunotherapy)

Multiple Sclerosis: Neuro-Technology and New Approaches for Treatment, Diagnosis and Symptom Monitoring

edited by

Michelangelo Dini

and Letizia Leocani

submission deadline 31 Jul 2026 | Viewed by 44 | Submission Open

Keywords: multiple sclerosis; treatment; neuromodulation; digital biomarkers; digital tools; artificial intelligence; wearable sensors; eHealth

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Advances in Radiological and Optical Imaging for Clinical Oncology

edited by

Jia-Sheng Hong

and

Wei-Kai Lee

submission deadline 31 Jul 2026 | Viewed by 44 | Submission Open

Keywords: clinical oncology; medical imaging; artificial intelligence; deep learning; radiomics; image-guided therapy; treatment response; prognosis; optical imaging; precision medicine

(This special issue belongs to the Section Cancer Biology and Oncology)

Insights into Musculoskeletal Diseases

edited by

Simon Fuk-Tan Tang

submission deadline 31 Jul 2026 | Viewed by 43 | Submission Open

Keywords: musculoskeletal diseases; myopathies; tendinopathy; tissue engineering; echo-guided injection; regenerative medicine

(This special issue belongs to the Section Molecular and Translational Medicine)

Molecular Diagnosis and Genomic Insights in Cancer

edited by Jingjing Hu

submission deadline 31 Jul 2026 | Viewed by 43 | Submission Open

Keywords: oncogenes; gene therapy; next-generation sequencing (NGS); targeted therapy; personalized medicine; cancer diagnosis; cancer therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Multidisciplinary Approaches in Complex Ear, Nose and Throat Pathology

edited by

Daniela Vrinceanu

and

Mihai Dumitru

submission deadline 31 Jul 2026 | Viewed by 41 | Submission Open

Keywords: complex ENT pathology; head and neck cancer; cancer; personalized therapy; trauma; sleep disorders; immune ENT diseases; artificial intelligence

(This special issue belongs to the Section Molecular and Translational Medicine)

Advanced Molecular Diagnosis and Treatment of Biliary Cancer

edited by Jing Han Hong

submission deadline 31 Jul 2026 | Viewed by 39 | Submission Open

Keywords: biliary tract cancer; cholangiocarcinoma; epigenetics; rare cancers; molecular characterisation; precision medicine; drug development; molecular heterogeneity; precision oncology; therapy; biomarkers; diagnosis; molecular mechanisms

(This special issue belongs to the Section Cancer Biology and Oncology)

Precision Microbiome Modulation for Metabolic and Inflammatory Diseases

edited by

Sidharth Mishra

submission deadline 31 Jul 2026 | Viewed by 34 | Submission Open

Keywords: gut microbiome; systemic inflammation; insulin resistance; non-alcoholic fatty liver disease (NAFLD); neuroinflammation; metabolic syndrome

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Natural Products in Cancer Research: From Traditional Medicine to Modern Drugs

edited by Chih-Jui Chang and

Che-Hsin Lee

submission deadline 31 Jul 2026 | Viewed by 34 | Submission Open

Keywords: natural products; cancer therapy; tranditional Chinese medicine (TCM); pharmacology; precision oncology; tanslational research

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Innovative Approaches in In Vitro Models: From Design to Application

edited by

Tina Maver

submission deadline 31 Jul 2026 | Viewed by 31 | Submission Open

Keywords: in vitro disease models; human cell isolation and characterization; organ-on-a-chip and microfluidic systems; 3D bioprinting and tissue engineering; translational biomedical research

(This special issue belongs to the Section Biomedical Engineering and Materials)

The Role of Immunity and Inflammation in Cardiovascular Diseases

edited by

Radu Sebastian Gavril

and

Florin Mitu

submission deadline 31 Jul 2026 | Viewed by 30 | Submission Open

Keywords: cardiovascular diseases; immunity; inflammation; atherosclerosis; vascular remodeling; biomarkers; microbiome; immunomodulation; targeted therapies

(This special issue belongs to the Section Immunology and Immunotherapy)

Advances in Heart Failure Pharmacotherapy

edited by Persoulla A. Nicolaou

submission deadline 31 Jul 2026 | Viewed by 27 | Submission Open

Keywords: heart failure; pharmacotherapy; precision medicine; pharmacogenomics; pharmacokinetics; pharmacodynamics

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

The Development of Cancer Immunotherapy (2nd Edition)

edited by

Satoshi Wada

submission deadline 31 Jul 2026 | Viewed by 24 | Submission Open

Keywords: cancer immunotherapy; immune checkpoint inhibitors; genetically modified T-cell therapy; hematological cancers; solid tumors

(This special issue belongs to the Section Cancer Biology and Oncology)

Metabolic Diseases—New Markers and Treatment Pathways

edited by Anna Różańska-Walędziak

submission deadline 31 Jul 2026 | Viewed by 24 | Submission Open

Keywords: metabolic diseases; diabetes; obesity; biomarkers; anti-diabetic medications

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Modern Approaches to Breast Cancer Biology and Therapy

edited by Zofia Łapińska and Anna Szewczyk

submission deadline 31 Jul 2026 | Viewed by 23 | Submission Open

Keywords: breast cancer; molecular pathology; hormonal therapy; estrogen receptor signaling; targeted therapies; immunotherapy; electric pulse-based therapies; precision oncology; biomarkers (ER/PR/HER2); multigene testing; combination therapies; therapeutic resistance; novel treatment strategies

(This special issue belongs to the Section Cancer Biology and Oncology)

Multidisciplinary Advances in Cancer Care—Innovations in Early Detection, Precision Medicine, and AI Driven Strategies

edited by Eva Y W Cheung,

Ricky Wu

and Ellie S.M. Chu

submission deadline 31 Jul 2026 | Viewed by 21 | Submission Open

Keywords: cancer early detection; multi-cancer screening; liquid biopsy; cancer biomarkers; tumor imaging and prognostics radiomics and artificial intelligence; precision oncology; targeted therapies; immunotherapy and tumor microenvironment; cancer prevention

(This special issue belongs to the Section Cancer Biology and Oncology)

New Insights into Bone and Cartilage Biology (2nd Edition)

edited by Vincent Yuan

submission deadline 31 Jul 2026 | Viewed by 20 | Submission Open

Keywords: bone remodeling; cartilage degeneration; osteoporosis osteoarthritis; mitochondrial function; protein modifications; immune signaling; therapeutic strategies

(This special issue belongs to the Section Molecular and Translational Medicine)

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