Skeletal Muscle Ageing: From Molecular Mechanism to Treatment
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 19
Special Issue Editors
Interests: musculoskeletal regeneration; neurophysiological degeneration; musculoskeletal aging issues; sarcopenia
Interests: skeletal muscle; muscular dystrophy; molecular mechanisms; signal transduction; extracellular matrix
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Skeletal muscle aging is a multifactorial process that contributes significantly to functional decline, frailty, and reduced quality of life in older adults. This Special Issue aims to explore the complex biological mechanisms underlying muscle aging, including cellular senescence, mitochondrial dysfunction, neuromuscular degeneration, and chronic inflammation. We welcome original research and reviews that investigate molecular pathways, biomarkers, and genetic factors associated with sarcopenia and musculoskeletal degeneration.
In addition to mechanistic insights, this issue will highlight translational approaches and emerging therapeutic strategies—ranging from pharmacological interventions and regenerative medicine to exercise physiology and nutritional modulation. Studies focusing on neurophysiological interactions, musculoskeletal regeneration, and integrative models of aging are particularly encouraged.
By bridging basic science with clinical applications, this Special Issue seeks to foster interdisciplinary dialogue and advance the development of effective treatments for age-related muscle loss. Researchers from fields such as orthopaedics, geriatrics, molecular biology, and rehabilitation are invited to contribute.
Dr. Can Cui
Dr. Manuela Bozzi
Guest Editors
Manuscript Submission Information
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Keywords
- skeletal muscle aging
- sarcopenia
- muscle regeneration
- neuromuscular degeneration
- molecular mechanisms of aging
- mitochondrial dysfunction
- inflammation and aging
- therapeutic interventions
- exercise and muscle health
- musculoskeletal disorders in aging
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