Esophageal Cancer: Pathogenesis and Therapeutic Strategies
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 61
Special Issue Editor
Interests: molecular biology; cancer biology; cell culture; cell signaling; western blot analysis; PCR; immunofluorescence; transfection; RNA isolation; cloning; co-immunoprecipitation; GST pull-down assay, ChIP assay, and CRISPR/Cas9 gene editing; establishment of transient and stable cell lines; transformation and lentivirus transduction; development of drug resistance cells (specifically to gemcitabine and paclitaxel)
Special Issue Information
Dear Colleagues,
Esophageal cancer arising from the lining of the esophagus has been classified into two main types: squamous cell carcinoma and adenocarcinoma. The main method of pathogenesis for esophageal cancers is chronic inflammation from acid reflux, which leads to Barrett’s esophagus and dysplasia. In addition, the consumption of tobacco and alcohol can induce cellular DNA damage and promote oxidative damage. Moreover, mutations in transcription factors and signaling pathways play crucial roles in pathogenesis. Therefore, understanding and identifying potential targets for esophageal cancer is the main goal of this Special Issue, which will focus on the following main categories:
- Understanding how the lineage of normal esophagus progressed to esophageal cancer;
- Major differences between squamous cell carcinoma and adenocarcinoma in terms of signaling pathway and targets;
- Gender differential roles in squamous cell carcinoma and adenocarcinoma;
- Identifying potential cancer and immune metabolisms;
- Biomarkers for clinical stage validation and targeting;
- Proposing new drugs to target esophageal cancer.
Dr. Boopathi Subramaniyan
Guest Editor
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Keywords
- ESCC
- EACC
- biomarkers
- transcription factors
- signaling pathways
- immune cells
- metabolism
- animal model
- cell lineage and gender
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