RNA Therapy in Cancer Treatment: From Design to Clinical Translation

Dear Colleagues,

This Special Issue explores the rapidly evolving field of RNA oncology therapy, focusing on innovations in molecular design, delivery platforms, and preclinical-to-clinical translation. We welcome submissions on the development of mRNA vaccines, non-coding RNA modulators (e.g., miRNA, siRNA, circRNA), and innovative strategies to overcome tumor resistance and immune evasion. Topics of interest include the following:

Novel RNA Therapies: mRNA vaccines targeting oncogenes or tumor suppressor genes, RNA interference, and antisense oligonucleotides.

Delivery Systems: Lipid nanoparticles, polymer vectors, and viral vectors optimized for tumor targeting and bioavailability.

Combination Therapy Regimens: Combining RNA therapy with immunotherapy, chemotherapy, or radiotherapy to enhance anti-tumor efficacy.

Clinical Advances: Biomarker-based patient stratification, combination therapy trials, and long-term safety assessments.

We welcome original research, reviews, and perspectives that connect RNA biology with clinical oncology, aiming to accelerate the application of precision RNA therapy in cancer treatment.

Dr. Zhouxiao Li
Guest Editor

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