Advances in the Diagnosis and Interventional Management of Peripheral Artery Disease: Emerging Technologies, Evidence, and Clinical Pathways

Dear Colleagues,

Peripheral artery disease (PAD) remains a major global cause of functional impairment, limb loss, and cardiovascular mortality. Despite progress in diagnostic imaging and endovascular therapies, significant gaps persist in early detection, lesion-specific assessment, and personalized treatment strategies. This Special Issue aims to provide an updated and comprehensive overview of contemporary PAD, focusing on innovative diagnostic tools, optimized interventional techniques, and evidence-based medical therapies. Topics of interest include advances in non-invasive testing, duplex and cross-sectional imaging, and the use of intravascular modalities for plaque characterization. Contributions addressing chronic total occlusions, calcified lesions, vessel preparation, drug-coated technologies, and comparative effectiveness between angioplasty strategies are particularly encouraged. We encourage submissions on antithrombotic management, risk factor optimization, and multidisciplinary approaches to chronic limb-threatening ischemia. Emerging areas such as artificial intelligence, computational modeling, digital health applications, and remote monitoring for PAD management are highly relevant.

This Special Issue aims to bring together high-quality original research and reviews to advance precision evaluation and treatment of PAD, and to define future directions in vascular medicine.

Dr. Ioannis Skalidis
Guest Editor

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