Advances in Heart Failure Pharmacotherapy
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Drug Discovery, Development and Delivery".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 702
Editor
Special Issue Information
Dear Colleagues,
Heart failure is the final common pathway for many cardiovascular risk factors and diseases. It is a complex clinical syndrome caused by structural or functional abnormalities that impair ventricular filling or ejection, in turn leading to an inability to meet metabolic demands. Despite advances in care, heart failure remains associated with high morbidity and mortality. An estimated 26 million people live with chronic heart failure worldwide, with substantial healthcare costs and marked reduction in quality of life. Guideline-directed medical therapy emphasizes the modulation of overactive neurohormonal pathways, using a quadruple regimen that includes β-blockers, renin angiotensin aldosterone system inhibitors or angiotensin receptor neprilysin inhibitors, mineralocorticoid receptor antagonists, and sodium glucose cotransporter 2 inhibitors. Treatment response varies widely between individuals, and the optimal regimen for a given patient may differ based on individual factors, such as sex, disease phenotype, complications, and co-morbidities.
This Special Issue focuses on advancing pharmacotherapy for heart failure, including studies focusing on personalized medicine. We welcome clinical and pre-clinical mechanistic studies, as well as rigorous evidence syntheses, that evaluate novel therapeutic targets, combinations, and treatment algorithms. Submissions that address variations in pharmacokinetics and pharmacodynamics, sequencing or dosing protocols, biomarker or genotype-guided care, and drug combinations that reduce adverse clinical outcomes while providing mechanistic insight are also encouraged.
Dr. Persoulla A. Nicolaou
Guest Editor
Manuscript Submission Information
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Keywords
- heart failure
- pharmacotherapy
- precision medicine
- pharmacogenomics
- pharmacokinetics
- pharmacodynamics
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