Rewiring Immune Fate: Immunometabolic and Epigenetic Mechanisms in Therapeutic Immunomodulation in Inflammation, Aging, and Cancer
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 46
Special Issue Editors
Interests: immune system aging; immunosenescence and immune rejuvenation; inflammaging; biology of T cell aging and immunity; metabolic instruction of T cell immunity; epigenetic reprogramming of T cells; immunotherapy for inflammatory conditions and age-related immune decline
Interests: innate and adaptive immunity; autoimmune induced inflammation; cytokine and chemokine mediated metabolic reprogramming in inflammation and cancer; cell and immunotherapy; importance of stromal components in tumor initiation and progression in solid tumors
Special Issue Information
Dear Colleagues,
The past decade has revealed how metabolism and chromatin dynamics drive immune cell fate, plasticity, and function, offering new avenues to recalibrate immune responses. These discoveries are redefining how immune responses can be reprogrammed to promote tissue repair, restore tolerance, enhance antitumor immunity, and potentially restore age-related decline in immune function. However, key challenges remain in translating these insights into precise, durable, and safe therapies that consider the complex interplay among immune, stromal, and metabolic networks. Complexities arise from the dynamic crosstalk among immune, stromal, and metabolic networks, as well as the context-dependent nature of epigenetic regulation. By integrating metabolic and epigenetic principles into immunotherapy, the field is poised to achieve next-generation interventions that can recalibrate the immune system with unprecedented precision and durability. This special topic seeks to highlight cutting-edge research, emerging technologies, and conceptual frameworks that bridge basic science discoveries to translational and therapeutic strategies. We invite submissions for an upcoming Special Issue dedicated to harnessing the immune system through metabolic and epigenetic programming for novel immunotherapies in the treatment of inflammation, aging, and cancer. Original research, reviews, and perspectives are welcome, particularly those offering integrative insights into metabolic and epigenetic processes that may shape the next generation of immune-based interventions.
Dr. Sandip Ashok Sonar
Dr. Thoihen Heikrujam
Guest Editors
Manuscript Submission Information
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Keywords
- immunotherapy
- cell therapy
- immunometabolism
- epigenetic reprogramming
- chronic inflammation
- immunosenescence
- anti-cancer immunity
- regeneration of the immune system
- system biology of immunometabolism
- tumor microenvironment
- neuroimmune communication
- graft versus host diseases
- stromal regulation of structure and function of lymphoid organs
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