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Biomedicines
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Cardiac Arrhythmias and Arrhythmogenic Disorders: Pathomechanisms, Diagnostics and Novel Treatment...
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Cardiac Arrhythmias and Arrhythmogenic Disorders: Pathomechanisms, Diagnostics and Novel Treatment Options

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 31 July 2026 | Viewed by 763

Editors

Dr. Michela Casella

E-Mail Website
Guest Editor
1. Cardiology and Arrhythmology Clinic, Marche Polytechnic University, University Hospital “Umberto I–Lancisi–Salesi”, 60126 Ancona, Italy
2. Maria Cecilia Hospital, GVM Care & Research, 48033 Cotignola, Italy
Interests: cardiac arrhythmias; cardiomyopathies; catheter ablation; ventricular arrhythmias; endomyocardial biopsy; genetics
Special Issues, Collections and Topics in MDPI journals
Dr. Yari Valeri

E-Mail Website
Guest Editor
Department of Biomedical Sciences and Public Health, Marche Polytechnic University, Ancona, Italy
Interests: cardiomyopathies; catheter ablation; atrial fibrillation; ventricular arrhythmias; cardiac pacing

Special Issue Information

Dear Colleagues,

Cardiac arrhythmias and heart diseases with predominantly arrhythmic manifestations are common disorders with high and rising prevalence and incidence. Interest in elucidating their arrhythmogenic, diagnostic, and therapeutic mechanisms has therefore increased markedly. The management of cardiac arrhythmias remains one of the most complex and rapidly evolving challenges in modern cardiology. A deep understanding of the underlying pathogenic mechanisms is essential to improve prevention, enable earlier diagnosis, and enhance therapeutic efficacy.

In recent years, clinical arrhythmology has advanced substantially, including improvements in the interpretation and use of biochemical and molecular biomarkers and their correlation with arrhythmic events. Diagnostic capabilities have also progressed: cardiac magnetic resonance imaging, cardiac computed tomography, advanced echocardiography, and increasingly specific molecular/biochemical assays now enable more accurate and targeted evaluation of arrhythmias. Therapeutically, beyond the development of novel drugs that act selectively on disease-specific pathways, the introduction of new energy modalities—such as electroporation-based (pulsed-field) ablation—has inaugurated a new era in the treatment of arrhythmias and arrhythmogenic conditions.

This Special Issue, “Cardiac Arrhythmias and Arrhythmogenic Disorders: Pathomechanisms, Diagnostics and Novel Treatment Options”, invites original research and review articles that critically examine recent advances in basic and clinical science. Priority topics include novel diagnostic techniques, predictive tools based on advanced technologies, and innovative therapeutic approaches, including pharmacological therapies, ablative strategies, and gene- or molecular-targeted interventions.

Dr. Michela Casella
Dr. Yari Valeri
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • arrhythmias
  • arrhythmogenic disorders
  • cardiomyopathies
  • genetics
  • cardiac MRI
  • atrial fibrillation
  • premature ventricular contraction
  • ventricular tachycardia
  • catheter ablation

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Published Papers (1 paper)

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Research

15 pages, 891 KB  
Article
Beyond QRS Duration: Myocardial Work Indices for the Assessment of Left Bundle Branch Block
by Magdalena Potapowicz-Krysztofiak, Martyna Dąbrowska, Małgorzata Maciorowska, Zbigniew Orski, Paweł Krzesiński, Marek Kiliszek and Beata Uziębło-Życzkowska
Biomedicines 2026, 14(4), 941; https://doi.org/10.3390/biomedicines14040941 - 21 Apr 2026
Viewed by 425
Abstract
Background: Left bundle branch block (LBBB) and QRS prolongation are markers of electrical dyssynchrony in heart failure, but they do not fully reflect its mechanical consequences. Myocardial work (MW)-derived indices may provide a more comprehensive assessment of left ventricular (LV) mechanical dyssynchrony. We [...] Read more.
Background: Left bundle branch block (LBBB) and QRS prolongation are markers of electrical dyssynchrony in heart failure, but they do not fully reflect its mechanical consequences. Myocardial work (MW)-derived indices may provide a more comprehensive assessment of left ventricular (LV) mechanical dyssynchrony. We evaluated associations between LV MW parameters, QRS duration, and LBBB in patients with heart failure with reduced ejection fraction (HFrEF) referred for ICD/CRT implantation. Methods: In this single-centre observational cross-sectional study, 96 consecutive patients referred for ICD or CRT implantation were screened. All patients underwent standardized baseline comprehensive echocardiography followed by advanced MW analysis. Myocardial work index (MWI) dispersion was assessed using two complementary methods. MWI dispersion (SD) was calculated as the standard deviation of segmental MWI values across all LV segments, and MWI dispersion (IQR) was defined as the interquartile range (IQR) of segmental MWI values. We evaluated the associations between QRS duration and MW-derived dyssynchrony parameters (individual and composite), as well as their discriminative performance for LBBB. Seven patients were excluded from further analysis due to inadequate echocardiography image quality. Results: The final study group comprised 89 patients with HFrEF (median age 65.5 years), of whom 67.4% were assigned to CRT. LBBB was present in 41.6%, and the median QRS duration was 142 ms (112–162). All analyzed LV MW indices were significantly associated with QRS duration (all q < 0.01). The strongest correlations were observed for MWI dispersion (IQR) (r = 0.58), peak strain dispersion (PSD) (r = 0.54), lateral–septal work asymmetry (r = 0.53), and MWI dispersion (SD) (r = 0.52) (all q < 0.0001). All MW indices differed significantly between patients with and without LBBB (all q ≤ 0.0001). MWI dispersion (IQR) showed the best single-marker discrimination of LBBB (AUC = 0.852). Composite indices achieved AUC = 0.84 but did not significantly improve discrimination versus MWI dispersion (IQR) alone. Conclusions: Myocardial work-derived indices of left ventricular dyssynchrony are strongly associated with QRS duration and the presence of LBBB in patients with HFrEF. Among them, MWI dispersion (IQR) was shown to be the best-performing MW marker for identifying LBBB. These findings suggest that MW dispersion may serve as a robust echocardiographic marker of mechanical dyssynchrony and warrants further investigation as a potential tool for predicting CRT response. Full article
(This article belongs to the Special Issue Cardiac Arrhythmias and Arrhythmogenic Disorders: Pathomechanisms, Diagnostics and Novel Treatment Options)
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