Biomedical Applications of Microfluidics
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Biomedical Engineering and Materials".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 54
Special Issue Editor
Special Issue Information
Dear Colleagues,
Microfluidics has emerged as a translational platform in biomedical science, allowing the precise manipulation of fluids, cells, and tissues within microscale environments. More than just miniaturization, it promotes the accurate recapitulation of the human-specific physiological environment. Organ-on-a-chip and lab-on-a-chip systems mimic key structural and functional characteristics of human organs, providing viable options to traditional cell cultures and animal models. This transition is becoming increasingly vital due to the rising demand for human-relevant non-animal methods (NAMs), driven by changing regulations and ethical concerns. Recent directives from the U.S. Food and Drug Administration (FDA) and the National Institutes of Health (NIH) emphasize the importance of NAM technologies in enhancing predictive accuracy in drug development while reducing the need for animal testing.
Microfluidics addresses this need by offering scalable, reproducible, and ethically sound platforms for preclinical research. The integration of real-time sensing technologies, mathematical modeling and simulation, and artificial intelligence and machine learning (AI/ML) further enhances its capabilities. For example, real-time biosensors in organ-on-a-chip models offer the continuous monitoring of immune responses and therapeutic efficacy. AI-driven analytics can reveal complex cellular interactions and optimize experimental designs, facilitating personalized treatment strategies. These advancements not only accelerate biomedical discovery but also align with NAM initiatives, positioning microfluidics as crucial for next-generation diagnostics, drug testing, and translational research, paving the way for safer health solutions.
This Special Issue is dedicated to the most recent innovations and emerging applications of microfluidics in the biomedical domain. Topics of interest include, but are not limited to, the following:
- Microfluidic systems for disease modeling and regenerative medicine;
- Organ-on-a-chip and lab-on-a-chip platforms;
- Integration of biosensors and real-time sensing technologies;
- AI/ML and mathematical modeling in microfluidic analysis;
- Microfluidics for personalized therapy and drug screening;
- Point-of-care testing (POCT) devices and clinical diagnostics.
We welcome both original research and comprehensive reviews that contribute to the advancement of microfluidics in biomedical science.
Dr. Surjendu Maity
Guest Editor
Manuscript Submission Information
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Keywords
- microfluidics
- organ-on-a-chip
- lab-on-a-chip
- disease modeling
- regenerative medicine
- cancer immunotherapy
- biosensors
- mathematical modeling
- AI/ML
- realtime sensing
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