Precision Microbiome Modulation for Metabolic and Inflammatory Diseases
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Microbiology in Human Health and Disease".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 34
Special Issue Editor
Special Issue Information
Dear Colleagues,
Disrupted gut microbial composition and loss of epithelial barrier integrity (“leaky gut”) are increasingly recognized as central drivers of chronic systemic inflammation, metabolic endotoxemia, insulin resistance, fatty liver disease, cardiovascular dysfunction, and neuroinflammation. Emerging evidence indicates that microbial metabolites, dietary components, and host–microbe interactions converge on mucosal immunity and tight junction regulation, creating new therapeutic opportunities. Identifying mechanistic pathways and microbiome-based interventions is critical for translating microbiota science into metabolic and clinical solutions.
This Special Issue will bring together cutting-edge research elucidating how gut microbes, microbial metabolites, and mucosal barrier function shape systemic health with emphasis on mechanistic discovery, biomarkers, precision nutrition, next-generation probiotics, and clinical translation.
We welcome original research, multi-omics studies, mechanistic animal or human models, clinical investigations, and comprehensive reviews related to the following:
- Gut microbiota regulation of barrier integrity, mucin biology, and tight-junction proteins (e.g., ZO-1, occludin, claudins);
- Endotoxemia, metabolic inflammation, and immune activation driven by gut microbes;
- Microbial metabolites impacting epithelial function: ethanolamine, SCFAs, bile acids, TMAO, and indoles;
- Diet-microbiome interactions and precision nutrition approaches for metabolic restoration;
- Next-generation probiotics, synbiotics, and postbiotics targeting gut permeability;
- Faecal microbiota transplantation, engineered probiotics, and microbiome-based therapeutics;
- Biomarkers and diagnostic signatures of barrier dysfunction or microbial dysbiosis;
- Clinical and translational studies in aging related ailments such as obesity, diabetes, NAFLD, cardiovascular disease, and neuroinflammation;
- Multi-omics integration (metagenomics, metabolomics, meta-transcriptomics, proteomics) in microbiome-mediated pathophysiology;
- Host–microbe crosstalk in gut immune regulation and mucosal inflammation.
Dr. Sidharth Mishra
Guest Editor
Manuscript Submission Information
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Keywords
- gut microbiome
- systemic inflammation
- insulin resistance
- non-alcoholic fatty liver disease (NAFLD)
- neuroinflammation
- metabolic syndrome
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