Multidisciplinary Approaches in Complex Ear, Nose and Throat Pathology

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 31 July 2026 | Viewed by 1218

Special Issue Editors


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Guest Editor
ENT Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Interests: head and neck pathology; cancer; immunology; salivary glands; thyroid; AI
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
ENT Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Interests: head and neck pathology; rhinology; immunology; salivary glands; AI; robotic surgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Today, otorhinolaryngology and head and neck surgery span over seven fields of activity, with a tendency towards supra-specialization (rhinology, skull base surgery, laryngology, phoniatrics, otology, neuro-otology, head and neck surgery, facial plastic surgery, pediatric ENT, and others). However, complex pathology requires input from other specialists, such as neurologists, neurosurgeons, radiologists, radiotherapists, oncologists, pathologists, dermatologists, allergologists and others. The development of such highly trained teams is necessary to enable personalized state-of-the-art treatment for every complex case, and recently this process has been accelerated due to the rise of telemedicine and AI-powered technology. The goal is to expedite treatment and increase the quality of life of the patients. This Special Collection aims to bring together the latest developments, research and advancements in the multidisciplinary management of complex ENT pathology. We welcome original research and reviews.

Potential topics for submissions include, but are not limited to,

  • Complex interdisciplinary management for nasal, laryngeal, and pharyngeal cancers.
  • Complex benign lesions of the aerodigestive tract, both pediatric and adult.
  • Interdisciplinary management of otology and neurotology pathology.
  • Interdisciplinary management of sleep disorders.
  • Immune diseases in ENT.
  • Artificial intelligence. 

Dr. Daniela Vrinceanu
Dr. Mihai Dumitru
Guest Editors

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Keywords

  • complex ENT pathology
  • head and neck cancer
  • cancer
  • personalized therapy
  • trauma
  • sleep disorders
  • immune ENT diseases
  • artificial intelligence

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Published Papers (1 paper)

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Review

24 pages, 2582 KB  
Review
Th9 and IL9 in Chronic Superior Airway Inflammation: A Narrative Review
by Mihai Dumitru, Ovidiu Berghi, Gabriela Musat, Crenguta Serboiu, Alina Oancea, Alina Gabriela Berghi, Adina Zamfir-Chiru-Anton and Daniela Vrinceanu
Biomedicines 2026, 14(5), 1026; https://doi.org/10.3390/biomedicines14051026 - 30 Apr 2026
Viewed by 826
Abstract
Inflammation at the superior airway level has multiple manifestations, and allergic rhinitis and chronic rhinosinusitis with or without polyps are two of the most frequent and troublesome of them, with innate and adaptive immunity being implicated. Dendritic cells, epithelial cells, neutrophils, macrophages, mucosal [...] Read more.
Inflammation at the superior airway level has multiple manifestations, and allergic rhinitis and chronic rhinosinusitis with or without polyps are two of the most frequent and troublesome of them, with innate and adaptive immunity being implicated. Dendritic cells, epithelial cells, neutrophils, macrophages, mucosal mast cells, eosinophils, basophils, innate lymphoid cells (ILCs), and NK cells are the players in innate immunity, while regulatory T (Treg), TH1, TH2, TH17, T follicular helper, and B cells are components of the adaptative immune system. Th9 cells, a subset of T helper cells discovered in 2008 that produce interleukin-9 (IL-9), play a vital role in the adaptive immune response and have advantageous and harmful effects in different diseases due to the induction pattern. We queried international databases for current, up-to-date information regarding the interplay between interleukin 9 (IL-9) and helper T cells (especially Th9 cells), and by other immune cells. Interleukin-9 has multiple immunological functions, acting on various target cells through its specific receptor (IL-9R), such as the following: the regulation of allergic (Th2-type) immune responses; effects on epithelial and mucosal cells, mast cells, and eosinophils; chronic inflammation; and autoimmunity. Thus, there is a further need to translate laboratory findings into clinical practice regarding IL-9. Full article
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