Special Issues

Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Extracellular Vesicles and Exosomes as Therapeutic Agents—2nd Edition submission deadline 31 Jan 2026 | Viewed by 211 | Submission Open
Keywords: extracellular vesicles; exosomes; therapeutics; drug delivery; bioengineering
(This special issue belongs to the Section Cell Biology and Pathology)
Advances in 3D Printing for Drug Delivery Systems
edited by , Cristina Manuela Drăgoi and Alina Crenguța Nicolae
submission deadline 31 Jan 2026 | Viewed by 201 | Submission Open
Keywords: 3D printing; drug delivery systems; personalized medicine; pharmaceutical engineering; controlled release
(This special issue belongs to the Section Biomedical Engineering and Materials)
Metabolic Disorders and Their Complications: From Molecular Mechanisms to Therapeutic Perspectives submission deadline 31 Jan 2026 | Viewed by 199 | Submission Open
Keywords: metabolism; diabetes; obesity; nutrition; AMPK and mTOR
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Advanced Research in Liver Diseases
edited by
submission deadline 31 Jan 2026 | Viewed by 192 | Submission Open
Keywords: liver; obesity; alcohol; oxidative stress; nutrients; vitamins; metabolism; homeostasis
(This special issue belongs to the Section Cell Biology and Pathology)
Organisms as Diagnostic Technologies: Harnessing Life for Sensing Mechanisms
edited by and Hideshi Ishii
submission deadline 31 Jan 2026 | Viewed by 187 | Submission Open
Keywords: biological sensors; diagnostic technologies; diagnostic technologies; biological sensing mechanisms; conversion of biological signals; bio-interfaces
(This special issue belongs to the Section Biomedical Engineering and Materials)
Biologics for Bone and Soft Tissue Regeneration: What Is New, What Is True—Second Edition submission deadline 31 Jan 2026 | Viewed by 184 | Submission Open
Keywords: regenerative medicine; stem cells; exosomes; musculoskeletal injuries; osteoarthritis; tissue regeneration; tissue engineering; biologics; bone; soft tissue
(This special issue belongs to the Section Biomedical Engineering and Materials)
Signal Peptides in Health and Disease: Molecular Mechanisms and Therapeutic Potential
edited by
submission deadline 31 Jan 2026 | Viewed by 176 | Submission Open
Keywords: signal peptides; protein targeting; protein trafficking; therapeutic peptides; synthetic signal peptides; signal recognition particle; drug delivery system; biomarker discovery
(This special issue belongs to the Section Molecular and Translational Medicine)
Shock Syndromes: Pathophysiology, Diagnostics and Emerging Therapeutics Across the Clinical Spectrum submission deadline 31 Jan 2026 | Viewed by 160 | Submission Open
Keywords: shock; critical illness; cardiogenic shock; septic shock; hypovolemic shock; obstructive shock; inflammation; hemodynamics; artificial intelligence in medicine; precision medicine; vasopressors; mechanical circulatory support; diagnostics
(This special issue belongs to the Section Molecular and Translational Medicine)
Exploring Antiangiogenic Agents in Drug Discovery: Molecular Mechanisms and Therapeutic Implications submission deadline 31 Jan 2026 | Viewed by 159 | Submission Open
Keywords: angiogenesis; antiangiogenic agents; signaling pathway; preclinical model; drug discovery; computational tools
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Biologic Drugs: The Evolution of Asthma Therapeutics submission deadline 31 Jan 2026 | Viewed by 158 | Submission Open
Keywords: severe asthma; IgE; IL-4; IL-5; IL-13; TSLP; monoclonal antibodies
(This special issue belongs to the Section Immunology and Immunotherapy)
New Advances in Neuroprotective Agent
edited by
submission deadline 31 Jan 2026 | Viewed by 157 | Submission Open
Keywords: mitochondrial disfunction; antioxidant molecules; gene therapy; stem cell; nanomedicine; cellular reprogramming
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Molecular Signatures and Therapeutic Strategies in Urological Cancers
edited by Haoyue Sheng
submission deadline 31 Jan 2026 | Viewed by 156 | Submission Open
Keywords: urological cancers; molecular signatures; precision medicine; non-coding RNAs; tumor microenvironment
(This special issue belongs to the Section Molecular and Translational Medicine)
New Treatments for Colorectal Cancer
edited by
submission deadline 31 Jan 2026 | Viewed by 155 | Submission Open
Keywords: biomarkers; signaling pathway; chemotherapy; reactive oxygen species; angiogenesis
(This special issue belongs to the Section Cancer Biology and Oncology)
Advancements in Research on Pancreatic Cancer: From Biomarkers to Targeted Therapies
edited by
submission deadline 31 Jan 2026 | Viewed by 155 | Submission Open
Keywords: pancreatic cancer; novel biomarkers; diagnostic techniques; therapeutic approaches
(This special issue belongs to the Section Cancer Biology and Oncology)
Cell Cycle in Normal Physiology and Disease
edited by
submission deadline 31 Jan 2026 | Viewed by 154 | Submission Open
Keywords: cell cycle; DNA replication; DNA damage; cyclins; cyclin-dependent kinases (CDKs); CDK inhibitors; cell proliferation; cancer
(This special issue belongs to the Section Cell Biology and Pathology)
Emerging Insights into HIV: Second Edition
edited by , Antonios Papadopoulos and
submission deadline 31 Jan 2026 | Viewed by 151 | Submission Open
Keywords: HIV/AIDS; antiretroviral treatment; comorbidities; co-infection; neuroHIV
(This special issue belongs to the Section Microbiology in Human Health and Disease)
The Latest Advancements in Tumor Drug Delivery Systems
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 150 | Submission Open
Keywords: tumor targeting; gene delivery; biomemetic drug delivery; cancer-targeting nanorobot; specific cancer cell targeting; antitumor immunotherapy; cancer nanovaccine; tumor-suppressing nanoenzyme
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Antibody Responses to Viral Infections: Insights from Structural Biology
edited by Pragati Agnihotri and
submission deadline 31 Jan 2026 | Viewed by 150 | Submission Open
Keywords: crystal structure; virus– antibody complexes; broadly neutralizing antibodies; immunology; epitope mapping
(This special issue belongs to the Section Microbiology in Human Health and Disease)
Risk Factors and Molecular Mechanisms in Diabetes and Cardiovascular Complications
edited by
submission deadline 31 Jan 2026 | Viewed by 147 | Submission Open
Keywords: diabetes; cardiovascular disease; atherosclerosis; ischemic heart disease; insulin resistance; risk factors; molecular mechanisms  
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Tumour Angiogenesis and Anti-Angiogenic Therapy submission deadline 31 Jan 2026 | Viewed by 144 | Submission Open
Keywords: tumour angiogenesis; vascularization; endothelial cells; pericytes; vascular endothelial growth factor (VEGF); bevacizumab; micro vessel density; anti-angiogenic therapy
(This special issue belongs to the Section Cancer Biology and Oncology)
Bioactive Lipids in Disease: Diagnosis, Prognosis, and Pathophysiology
edited by
submission deadline 31 Jan 2026 | Viewed by 143 | Submission Open
Keywords: bioactive lipids; eicosanoids; endocannabinoids; lysophospholipids; sphingolipids; oxysterols; bile acids; lipidomics; pathophysiology; biomarkers
(This special issue belongs to the Section Molecular and Translational Medicine)
Molecular Pathways and Their Clinical Implications in Ischemic Heart Disease and Heart Failure: From Pathophysiology to Therapeutic Strategies submission deadline 31 Jan 2026 | Viewed by 140 | Submission Open
Keywords: ischemic heart disease; heart failure; molecular mechanisms; biomarkers; targeted therapy; precision medicine
(This special issue belongs to the Section Molecular and Translational Medicine)
Pharmacogenetics and Pharmacogenomics: Driving Forces in Modern Precision Medicine
edited by Miriam Saiz-Rodríguez and Dora Koller
submission deadline 31 Jan 2026 | Viewed by 134 | Submission Open
Keywords: pharmacogenetics; pharmacogenomics; precision medicine; polygenic risk scores; phenoconversion; drug response; genetic biomarkers; personalized therapy; underrepresented populations; clinical implementation
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Advances in Cancer Metastasis Modeling: From Mechanisms to Therapies
edited by
submission deadline 31 Jan 2026 | Viewed by 130 | Submission Open
Keywords: cancer metastasis; tumor microenvironment; extracellular matrix; metastasis models; drug resistance; in vivo imaging; molecular mechanisms; targeted therapy; computational modeling; and antibody-drug conjugates
(This special issue belongs to the Section Cancer Biology and Oncology)
Mechanisms and Novel Therapeutic Approaches for Nephrology
edited by
submission deadline 31 Jan 2026 | Viewed by 129 | Submission Open
Keywords: chronic kidney disease; acute kidney injury; therapeutics; molecular mechanisms; biomarkers; drug discovery; regenerative medicine; precision medicine
(This special issue belongs to the Section Molecular and Translational Medicine)
Tumor Microenvironment in Head and Neck Squamous Cell Carcinoma
edited by Julia Federspiel, and
submission deadline 31 Jan 2026 | Viewed by 120 | Submission Open
Keywords: head and neck oncology 3D tumor models; cancer-associated fibroblasts; phototherapy; exosomes
(This special issue belongs to the Section Cancer Biology and Oncology)
Microbiota and Immunity in Cancers
edited by Davide Frumento
submission deadline 31 Jan 2026 | Viewed by 118 | Submission Open
Keywords: immunology; cancer; microbiota; immunotherapy; probiotics; oncology
(This special issue belongs to the Section Molecular and Translational Medicine)
Dopamine in Health and Disease (3rd Edition)
edited by
submission deadline 31 Jan 2026 | Viewed by 114 | Submission Open
Keywords: dopamine; disease models; mitochondria; Parkinson’ s disease; schizophrenia
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Innovations in Understanding and Treating Pancreatic Diseases
edited by
submission deadline 31 Jan 2026 | Viewed by 109 | Submission Open
Keywords: pancreatic cancer; pancreatitis; tumor microenvironment; epithelial– mesenchymal transition (EMT); metastasis; liver metastatic niche; immunotherapy; biomarkers; targeted therapies; inflammation and fibrosis
(This special issue belongs to the Section Cell Biology and Pathology)
Emerging Therapeutic Approaches to Head and Neck Cancer
edited by and Daria Maria Filippini
submission deadline 31 Jan 2026 | Viewed by 98 | Submission Open
Keywords: head and neck cancer; HPV-related head and neck cancer; EBV-related nasopharyngeal cancer; prognostic biomarkers; predictive biomarkers; novel combinations; tumor microenvironment
(This special issue belongs to the Section Cancer Biology and Oncology)
Nanoparticles in Medicine: The Potential of “Empty” Nanoparticles and Future Challenges
edited by Cuthbert O Simpkins and
submission deadline 31 Jan 2026 | Viewed by 96 | Submission Open
Keywords: nanoparticles; empty nanoparticles; nanoparticle technology
(This special issue belongs to the Section Nanomedicine and Nanobiology)
Advances in Allergies and Autoimmunity
edited by
submission deadline 31 Jan 2026 | Viewed by 91 | Submission Open
Keywords: asthma; arthritis; diabetes; inflammatory bowel disease; dermatomyositis; Sjö gren's syndrome; systemic lupus erythematosus; psoriasis; multiple sclerosis
(This special issue belongs to the Section Cell Biology and Pathology)
Advances in Cancer Cell Metabolism and Tumor Microenvironment
edited by
submission deadline 31 Jan 2026 | Viewed by 91 | Submission Open
Keywords: metabolism; cancer; immune cells; tumor microenvironment; cancer-associated organ failure; cancer therapeutics
(This special issue belongs to the Section Endocrinology and Metabolism Research)
The Prefrontal Cortex in Cognition and Diseases
edited by
submission deadline 31 Jan 2026 | Viewed by 87 | Submission Open
Keywords: executive function; working memory; behavioral inhibition; attention; anxiety; social behavior; ADHD (attention-deficit hyperactivity disorder); schizophrenia; MDD (major depressive disorder); AD (Alzheimer's disease); PD (Parkinson’ s disease)
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Biochemical and Molecular Perspectives on Engineered Nanoparticles for Cancer Therapy submission deadline 10 Feb 2026 | Viewed by 212 | Submission Open
Keywords: cancer; oxidative stress; engineered nanoparticles (ENPs); drug delivery; biochemical processes; ferroptosis; apoptosis; cell death; molecular interactions; tumor microenvironment
(This special issue belongs to the Section Cancer Biology and Oncology)
Innovations in Bone and Craniofacial Tissue Engineering: From Biomaterials and Mechanobiology to Clinical Applications
edited by Zhekai Hu
submission deadline 15 Feb 2026 | Viewed by 198 | Submission Open
Keywords: bone tissue engineering; craniofacial regeneration; biomaterials and scaffolds; stem cells and exosomes; mechanobiology and orthodontic forces; osteoimmunology; oxidative stress modulation; gene/drug delivery; translational research; periodontal and alveolar bone regeneration
(This special issue belongs to the Section Biomedical Engineering and Materials)
Emerging Trends in Malignant Mesothelioma
edited by Yuan Xu
submission deadline 20 Feb 2026 | Viewed by 279 | Submission Open
Keywords: mesothelioma; asbestos; novel therapeutic strategies; treatment resistance; multi-omics analysis
(This special issue belongs to the Section Cancer Biology and Oncology)
Autophagic Signatures in Health and Disease: Molecular Insights and Clinical Applications submission deadline 20 Feb 2026 | Viewed by 151 | Submission Open
Keywords: autophagy; pathology; physiology; therapy; methods
(This special issue belongs to the Section Cell Biology and Pathology)
Obstructive Sleep Apnea: Mechanisms, Comorbidities, and Optimization of Emerging and Established Therapies submission deadline 25 Feb 2026 | 3 articles | Viewed by 6315 | Submission Open
Keywords: obstructive sleep apnea; sleep-disordered breathing; pathophysiology; cardiometabolic comorbidities; precision medicine; CPAP; sleep diagnostics; biomarkers; neurocognitive impairment; new therapies
(This special issue belongs to the Section Molecular and Translational Medicine)
Current Trends in Diabetic Foot Disease
edited by Xuefeng Yu
submission deadline 27 Feb 2026 | Viewed by 263 | Submission Open
Keywords: diabetes; diabetic foot; endocrinology; metabolic disease
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Pathology, Complications and Prognosis of Type 1 Diabetes
edited by Maurizio Delvecchio
submission deadline 27 Feb 2026 | Viewed by 83 | Submission Open
Keywords: type 1 diabetes mellitus; autoimmune β -cell destruction; diabetic complications; microvascular and macrovascular damage; diabetic ketoacidosis; glycemic control; disease prognosis; immunopathogenesis
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Advanced Research of Gut Microbiota in Health and Diseases—2nd Edition submission deadline 28 Feb 2026 | 8 articles | Viewed by 26356 | Submission Open
Keywords: microbiota; gut; dysbiosis; gut microbiome; pathological conditions; metabolic disorders; autoimmune disease; inflammatory disorders; degenerative diseases
(This special issue belongs to the Section Molecular and Translational Medicine)
Cellular and Molecular Biology of Neurodegenerative Disorders
edited by
submission deadline 28 Feb 2026 | 6 articles | Viewed by 19557 | Submission Open
Keywords: neurodegeneration; omics; biomarkers; systems biology; disease-modifying therapies
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Natural Product for the Interventions of Chronic Diseases: From Source to Therapy
edited by
submission deadline 28 Feb 2026 | 4 articles | Viewed by 18833 | Submission Open
Keywords: natural products; chronic diseases; drug discovery; pharmacodynamics; pharmacokinetics; nanotechnology
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Musculoskeletal Injuries: Clinical, Radiological, and Biochemical Evaluation in Orthopedics submission deadline 28 Feb 2026 | 7 articles | Viewed by 17775 | Submission Open
Keywords: orthopedic surgery; sports injuries; bone cancer; diabetic foot; clinical evaluation; radiological evaluation; biomarkers; prognostic markers
(This special issue belongs to the Section Molecular and Translational Medicine)
Glioblastoma: Pathogenetic, Diagnostic and Therapeutic Perspectives submission deadline 28 Feb 2026 | 5 articles | Viewed by 17594 | Submission Open
Keywords: drug delivery methods (TTFields; nanoparticles); immunotherapy; oncolytic virotherapy; cell metabolism (glycolysis; OXPHOS; fatty acid oxidation); epigenetic; biomarkers; gene therapy (CRISPR/Cas9)
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Cellular and Pathogenesis Mechanisms in Oral Cancer
edited by
submission deadline 28 Feb 2026 | 5 articles | Viewed by 15449 | Submission Open
Keywords: oral carcinogenesis; oral cancer model; OSCC; oral cytology; biomarkers; targeted therapies; precision medicine; bioinformatics
(This special issue belongs to the Section Molecular and Translational Medicine)
Feature Reviews in Cell Death
edited by and Madalina Nistor
submission deadline 28 Feb 2026 | 4 articles | Viewed by 14303 | Submission Open
Keywords: cell death pathways; apoptosis; necrosis; biomarkers; therapies
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Feature Reviews in Mesenchymal Stem Cells submission deadline 28 Feb 2026 | 3 articles | Viewed by 13356 | Submission Open
Keywords: mesenchymal stem cells; tissue repair and regeneration; immunomodulatory functions
(This special issue belongs to the Section Cell Biology and Pathology)
Progress in Cardiovascular Pharmacology submission deadline 28 Feb 2026 | 3 articles | Viewed by 12149 | Submission Open
Keywords: cardiovascular diseases; cardiovascular pharmacology; target therapies; molecular pharmacology; heart failure; preventive cardiology; atherosclerosis
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
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