Current Trends in Diabetic Foot Disease

Dear Colleagues,

Diabetic foot ulcer (DFU) is one of the most refractory complications in diabetes mellitus, resulting in enormous economic, social, and public health burdens. Normal wound healing includes four continuous phases, that is, hemostasis, inflammation, proliferation, and remodeling. Diabetes causes delayed wound healing via multifarious biological mechanisms, which affect the transition of the organized phases.

Conventional therapeutic strategies of DFU consist of glucose and infection control, debridement, wound off-loading, dressings, and revascularization. However, the healing duration of DFUs ranges from 3 months to more than 12 months after these current treatments. It is of significant interest to develop more effective and economic treatments for DFUs.

This Special Issue welcomes the submission of original research articles, clinical trials, case report, reviews, short communications, and commentaries on the new therapeutic strategies targeting these mechanisms, such as bioengineered skin substitutes, exogenous growth factors, drugs regulating unbalanced inflammatory responses, and the transplantation of stem/progenitor cells.

Prof. Dr. Xuefeng Yu
Guest Editor

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