Tumour Angiogenesis and Anti-Angiogenic Therapy
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 15
Special Issue Editor
Interests: cancer stem cells; tumour angiogenesis; three-dimensional model of cancer cells; environmental toxicology; proteomics and metabolomics
Special Issue Information
Dear Colleagues,
The traditional perspective on tumour vascularization holds that tumours derive their blood supply from the surrounding normal stroma. However, research has shown that alternative mechanisms, including intussusceptive angiogenesis, vasculogenic mimicry, vessel co-option, and vasculogenesis, also contribute to tumour vascularization. Various immunohistochemistry (IHC) studies on tumour biopsies identified tumour blood vessel markers (e.g., CD31, CD34 on endothelial cells and Smooth Muscle Actin (SMA), Desmin on pericytes). Some of these tumour blood vessel markers were developed into tumour diagnostic markers and therapeutic targets. Micro-vessel density of tumour blood vessel markers by IHC in solid tumours helps to understand the extent of tumour angiogenesis. Moreover, signal transduction pathways such as THE vascular endothelial growth factor (VEGF) pathway was identified as one of the potential anti-angiogenic therapies in different cancers. Developing therapeutic drugs such as monoclonal antibodies to target tumour blood vessel markers is a promising approach to prevent tumour progression as well as its metastasis. This Special Issue highlights recent advancements in identifying and characterizing tumour blood vessel biomarkers, as well as anti-angiogenic therapies designed for clinical applications to target vascularization across various tumour types. The goal is to encourage new research in tumour angiogenesis, fostering the development of therapeutic drugs aimed at targeting tumour vascularization thereby preventing tumour progression and metastasis of tumours.
Dr. Krishna Priya Syama
Guest Editor
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Keywords
- tumour angiogenesis
- vascularization
- endothelial cells
- pericytes
- vascular endothelial growth factor (VEGF)
- bevacizumab
- micro vessel density
- anti-angiogenic therapy
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