Exploring Antiangiogenic Agents in Drug Discovery: Molecular Mechanisms and Therapeutic Implications
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Drug Discovery, Development and Delivery".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 10
Special Issue Editor
Interests: natural products; pharmacognosy; angiogenesis; chemoprevention; angioprevention; tumor promoting inflammation; antiarthritis; gastroprotective
Special Issue Information
Dear Colleagues,
Angiogenesis, the formation of new blood vessels from pre-existing ones, plays a critical role in both health and disease. While it is essential for tissue repair, wound healing, and embryonic development, its dysregulation can contribute to various diseases such as cancer, cardiovascular diseases, and retinal disorders. It is also involved in the pathogenesis of inflammatory diseases such as rheumatoid arthritis, where it can foster the infiltration of inflammatory cells into the joints. Therefore, the inhibition of angiogenesis in disease pathways has become crucial for the development of new therapeutic strategies for diseases in which it plays an important role. Current anti-angiogenic drugs established for the treatment of various conditions are still being developed. Examples of such molecules include anti-VEGF and tyrosine kinase inhibitors (TKIs), used to treat various types of cancer. In the field of drug discovery, the development of new drugs that may directly target angiogenesis or act as adjuvants in the treatment of diseases is essential to minimize the risk of drug resistance and adverse effects. Thus, we consider this subject to be of particular interest; the topic can expand biomedicine toward new horizons.
We invite authors to submit original research and review articles on phytochemicals or synthetic compounds that inhibit angiogenesis via their mechanistic pathways as potential antiangiogenic agents. Potential topics include, but are not limited to, the following:
- Mechanistic pathways involving growth factors in preclinical and clinical models;
- Crosstalk signaling as part of antiangiogenic mechanisms;
- Exploring synergistic approaches and leveraging computational tools to accelerate the development of more effective and targeted anti-angiogenic therapies;
- Recent advancements in antiangiogenic therapy.
Dr. Roslida Abdul Hamid
Guest Editor
Manuscript Submission Information
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Keywords
- angiogenesis
- antiangiogenic agents
- signaling pathway
- preclinical model
- drug discovery
- computational tools
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