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Biomedicines
Special Issues
Feature Reviews in Cell Death
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Feature Reviews in Cell Death

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 3168

Special Issue Editors

Dr. Adrian-Bogdan Țigu

E-Mail Website
Guest Editor
Department of Translational Medicine, Institute of Medical Research and Life Sciences—MEDFUTURE, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania
Interests: signaling pathways; biochemistry; cell-culture; cell death mechanism; cancer research; hematology
Special Issues, Collections and Topics in MDPI journals
Dr. Madalina Nistor

E-Mail Website
Guest Editor
Department of Translational Medicine, Institute of Medical Research and Life Sciences—MEDFUTURE, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania
Interests: cell death mechanisms; cell signaling; molecular biology; tumor biology

Special Issue Information

Dear Colleagues,

This Special Issue aims to present a comprehensive collection of state-of-the art reviews exploring the multifaced mechanism of cell death and its implication in different diseases and therapies. The latest advancements in the field are welcomed, debating molecular pathways governing apoptosis, necrosis, or autophagy and the intricate roles of cell death in development, disease, and therapy. We encourage scientists to submit their papers on in-depth analysis of novel biomarkers, cutting-edge techniques, and emerging therapeutic strategies targeting cell death pathways. By integrating diverse perspectives and innovative research, this collection will serve as a valuable resource for scientists and clinicians seeking to understand cell death and how to manipulate it for improved health outcomes.

Aims and scope

This Special Issue highlights the importance of cell death studies in the context of personalized medicine, precision oncology, and regenerative medicine. By elucidating the complex interplay between cell death and disease states, this collection aims to provide a platform for researchers to exchange ideas, share their latest findings and collaborate on innovative approaches to harnessing the power of cell death for therapeutic purposes.

We welcome contributions that address the challenges and opportunities in translating basic research on cell death into clinical applications, thereby identifying potential novel druggable targets and developing new strategies for personalized treatments.

This Special Issue will be a comprehensive resource for researchers, clinicians, and industry professionals interested in advancing our understanding of cell death and its implication in human health. We look forward to receiving high-quality submissions that will contribute to the growing body of knowledge on this crucial biological process and its therapeutic potential.

This collection aims to include only review papers: comprehensive reviews, systematic reviews, and literature reviews.

Dr. Adrian-Bogdan Țigu
Dr. Madalina Nistor
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cell death pathways
  • apoptosis
  • necrosis
  • biomarkers
  • therapies

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

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15 pages, 3257 KiB  
Article
Unveiling the Potency of Gardenia Extract Against H. pylori: Insights from In Vitro and In Vivo Studies
by Pornpen Werawatganone, Duangporn Werawatganon, Nattida Noonak, Maneerat Chayanupatkul, Tanittha Chatsuwan, Naruemon Klaikeaw, Walaisiri Muangsiri and Prasong Siriviriyakul
Biomedicines 2025, 13(1), 92; https://doi.org/10.3390/biomedicines13010092 - 2 Jan 2025
Viewed by 897
Abstract
Background and aim: Gardenia jasminoides (G. jasminoides) could treat various inflammatory diseases. This study aimed to investigate the effects of G. jasminoides fruit extract on gastric inflammation and protective mechanisms in Helicobacter pylori (H. pylori)-induced gastritis. Experimental procedure: G. [...] Read more.
Background and aim: Gardenia jasminoides (G. jasminoides) could treat various inflammatory diseases. This study aimed to investigate the effects of G. jasminoides fruit extract on gastric inflammation and protective mechanisms in Helicobacter pylori (H. pylori)-induced gastritis. Experimental procedure: G. jasminoides fruit extract was prepared and analyzed for geniposide content. The inhibitory effect of the extract on H. pylori growth was investigated using the disk diffusion method. The in vitro anti-inflammatory property of the extract was evaluated using the erythrocyte membrane stabilization method. Thirty-five male Sprague–Dawley rats were inoculated with H. pylori (108–1010 colony-forming unit/mL) and divided into five groups. Each group was treated with various doses of the extract (98–395 mg/kg). The serum and stomach tissue of the rats were evaluated using enzyme-linked immunosorbent assay, histopathology, and immunohistochemistry. Results and conclusions: The geniposide content in the dried extract was 8.12% ± 0.79% by dry weight. The inhibition zone was observed at the extract ≥ 1.97 mg/disk, and the extract presented anti-inflammatory potential. The H. pylori-inoculated rats had a significant increase in serum interleukin (IL)-17, IL-33, and gastric epidermal growth factor (EGF) levels and a significant decrease in serum prostaglandin E2 level (p < 0.05) in conjunction with the development of gastric inflammation on histopathology. The treatment of the extract could significantly decrease the serum IL-17, IL-33, and gastric EGF levels, significantly increase the serum PGE2 level (p < 0.05), and improve gastric histopathology. Thus, G. jasminoides fruit extract attenuated H. pylori-induced gastritis by inhibiting bacterial growth, reducing inflammation, and enhancing protective mechanisms. Full article
(This article belongs to the Special Issue Feature Reviews in Cell Death)
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Review

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21 pages, 1369 KiB  
Review
Immunogenic Cell Death and Metabolic Reprogramming in Cancer: Mechanisms, Synergies, and Innovative Therapeutic Strategies
by Jie Jiang, Yan Yan, Chunhui Yang and Hong Cai
Biomedicines 2025, 13(4), 950; https://doi.org/10.3390/biomedicines13040950 - 12 Apr 2025
Viewed by 530
Abstract
Immunogenic cell death (ICD) is a promising cancer therapy where dying tumor cells release damage-associated molecular patterns (DAMPs) to activate immune responses. Recent research highlights the critical role of metabolic reprogramming in tumor cells, including the Warburg effect, oxidative stress, and lipid metabolism, [...] Read more.
Immunogenic cell death (ICD) is a promising cancer therapy where dying tumor cells release damage-associated molecular patterns (DAMPs) to activate immune responses. Recent research highlights the critical role of metabolic reprogramming in tumor cells, including the Warburg effect, oxidative stress, and lipid metabolism, in modulating ICD and shaping the immune microenvironment. These metabolic changes enhance immune activation, making tumors more susceptible to immune surveillance. This review explores the molecular mechanisms linking ICD and metabolism, including mitochondrial oxidative stress, endoplasmic reticulum (ER) stress, and ferroptosis. It also discusses innovative therapeutic strategies, such as personalized combination therapies, metabolic inhibitors, and targeted delivery systems, to improve ICD efficacy. The future of cancer immunotherapy lies in integrating metabolic reprogramming and immune activation to overcome tumor immune evasion, with multi-omics approaches and microbiome modulation offering new avenues for enhanced treatment outcomes. Full article
(This article belongs to the Special Issue Feature Reviews in Cell Death)
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38 pages, 4838 KiB  
Review
Sesquiterpene Lactones as Promising Anti-Glioblastoma Drug Candidates Exerting Complex Effects on Glioblastoma Cell Viability and Proneural–Mesenchymal Transition
by Andrey V. Markov, Arseny D. Moralev and Kirill V. Odarenko
Biomedicines 2025, 13(1), 133; https://doi.org/10.3390/biomedicines13010133 - 8 Jan 2025
Viewed by 1002
Abstract
Glioblastoma is one of the most aggressive brain cancers, characterized by active infiltrative growth and high resistance to radiotherapy and chemotherapy. Sesquiterpene triterpenoids (STLs) and their semi-synthetic analogs are considered as a promising source of novel anti-tumor agents due to their low systemic [...] Read more.
Glioblastoma is one of the most aggressive brain cancers, characterized by active infiltrative growth and high resistance to radiotherapy and chemotherapy. Sesquiterpene triterpenoids (STLs) and their semi-synthetic analogs are considered as a promising source of novel anti-tumor agents due to their low systemic toxicity and multi-target pharmacological effects on key processes associated with tumor progression. The current review aims to systematize the knowledge on the anti-glioblastoma potential of STLs accumulated over the last decade and to identify key processes in glioblastoma cells that are most susceptible to the action of STLs. An analysis of published data clearly demonstrated that STLs, which can successfully cross the blood–brain barrier, exert a complex inhibitory effect on glioblastoma cells through the induction of the “mitochondrial dysfunction–oxidative stress–apoptosis” axis, the inhibition of glucose metabolism and cell cycle phase transition, and the suppression of glioblastoma cell motility and invasion through the blockade of proneural–mesenchymal transition. Taken together, this review highlights the promising anti-glioblastoma potential of STLs, which are not only able to induce glioblastoma cell death, but also effectively affect their diffusive spread, and suggests the possible directions for further investigation of STLs in the context of glioblastoma to better understand their mechanism of action. Full article
(This article belongs to the Special Issue Feature Reviews in Cell Death)
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