Cell Cycle in Normal Physiology and Disease
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 37
Special Issue Editor
2. Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Boston, MA, USA
Interests: cell cycle; cancer biology; genetics; gene expression regulation; bioinformatics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The cell cycle is a fundamental biological process that governs cell growth, DNA replication, and division. It is essential for the development, maintenance, and repair of all multicellular organisms. Comprising tightly regulated phases—G1, S, G2, and M—the cell cycle ensures accurate duplication and distribution of genetic material. This coordination is maintained by a complex network of signaling pathways, checkpoints, and regulatory proteins such as cyclins and cyclin-dependent kinases (CDKs), which together preserve genomic integrity and tissue homeostasis.
In normal physiology, the cell cycle plays a crucial role in embryogenesis, tissue renewal, and immune responses. Its proper regulation allows organisms to adapt to physiological demands, repair damage, and replace senescent cells. However, dysregulation of the cell cycle is a hallmark of numerous diseases, most notably cancer. Aberrant activation of cell cycle components can lead to uncontrolled cell proliferation, genomic instability, and resistance to cell death, all of which contribute to tumor initiation and progression. Additionally, cell cycle anomalies are implicated in other pathological conditions such as neurodegenerative disorders, cardiovascular diseases, and developmental abnormalities.
Understanding the mechanisms that govern the cell cycle under normal and pathological conditions is critical for identifying novel therapeutic targets. Advances in cell cycle research have led to the development of CDK inhibitors and other cell cycle-targeted therapies, some of which are now in clinical use. Continued investigation into cell cycle regulation offers the potential to uncover new diagnostic markers and improve treatment strategies for a broad spectrum of diseases.
This Special Issue will cover all areas of the cell cycle and checkpoint control in normal and cancer cells. Both original research articles and reviews are welcome.
Dr. Chen Chu
Guest Editor
Manuscript Submission Information
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Keywords
- cell cycle
- DNA replication
- DNA damage
- cyclins
- cyclin-dependent kinases (CDKs)
- CDK inhibitors
- cell proliferation
- cancer
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