Innovations in Understanding and Treating Pancreatic Diseases
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 18
Special Issue Editor
Special Issue Information
Dear Colleagues,
Pancreatic diseases, including pancreatitis and pancreatic cancer, represent some of the most challenging conditions in gastroenterology and oncology due to their complex pathogenesis, late diagnosis, and limited therapeutic options. Despite advances in molecular and translational research, patient outcomes remain poor, especially in pancreatic ductal adenocarcinoma (PDAC), where the tumor microenvironment, immune evasion, and metastatic spread to organs like the liver play central roles.
This Special Issue aims to provide a platform for cutting-edge research that unravels the cellular, molecular, and immunological mechanisms underlying pancreatic disorders. We welcome original research and reviews addressing topics such as the genetic and epigenetic drivers of pancreatic disease, inflammation–fibrosis–cancer transition, epithelial–mesenchymal transition (EMT), tumor microenvironment remodeling, immune regulation, and mechanisms of metastasis. Special emphasis will be given to translational and clinical studies exploring novel biomarkers, targeted therapies, immunotherapies, and innovative treatment strategies that may reshape patient management.
By gathering contributions across disciplines—from basic science to clinical applications—this Special Issue seeks to advance our understanding of pancreatic diseases and promote the development of more effective, personalized interventions.
Dr. Federica Rubbino
Guest Editor
Manuscript Submission Information
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Keywords
- pancreatic cancer
- pancreatitis
- tumor microenvironment
- epithelial–mesenchymal transition (EMT)
- metastasis
- liver metastatic niche
- immunotherapy
- biomarkers
- targeted therapies
- inflammation and fibrosis
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