Bioactive Lipids in Disease: Diagnosis, Prognosis, and Pathophysiology
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 28
Special Issue Editor
Special Issue Information
Dear Colleagues,
The paradigm of lipid biology has evolved dramatically, shifting the scholarly view of lipids from simple structural components or energy depots to critical regulators of cellular and systemic physiology. Among them, bioactive lipids represent an exceptionally diverse and potent class of signaling molecules that regulate a vast array of biological processes. A deeper understanding of these lipids is fundamental to unraveling the mechanisms underlying numerous human diseases, including metabolic disorders, cardiovascular diseases, cancer, and neurodegenerative conditions.
A key feature of bioactive lipids is their ability to enter systemic circulation, making them highly valuable as accessible biomarkers. Their dynamic levels in blood and other biofluids can reflect underlying pathological states, offering powerful tools for early diagnosis, patient stratification, prognostic assessment, and therapeutic response monitoring.
Despite substantial progress in lipidomics research, a significant proportion of bioactive lipids remains uncharacterized. The integration of advanced analytical methodologies presents opportunities for the discovery and functional characterization of novel bioactive lipid entities.
This Special Issue welcomes research contributions that enhance our understanding of bioactive lipids in disease, including studies on disease mechanisms, biomarker identification, therapeutic applications, and new methodological developments in lipid research. We encourage submissions of both original research articles and comprehensive review articles that bridge scientific discoveries with clinical applications.
Dr. Xu Zhang
Guest Editor
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Keywords
- bioactive lipids
- eicosanoids
- endocannabinoids
- lysophospholipids
- sphingolipids
- oxysterols
- bile acids
- lipidomics
- pathophysiology
- biomarkers
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