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Biology publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms of Bone Metastasis in Cancer

edited by Ana Carolina Dos Santos Monteiro

submission deadline 15 Jul 2026 | 1 articles | Viewed by 2267 | Submission Open

Keywords: bone metastasis; osteoimmunology; tumor–immunity interactions; myeloid-derived suppressor cells; RANKL/OPG signaling; TGF-β; Wnt; immune evasion; extracellular vesicles; metastatic niche; cancer cell dormancy; preclinical models

(This special issue belongs to the Section Cancer Biology)

Plant Perception, Behavior, and Environmental Response Mechanisms

edited by

Silvia Guerra

and Bianca Bonato

submission deadline 15 Jul 2026 | Viewed by 391 | Submission Open

Keywords: plant perception; plant movement; social cognition; communication; plant behavior; climbing plants; interactions; plant–plant interactions; environment; plant–environment interactions

(This special issue belongs to the Section Plant Science)

Methods in Bioinformatics and Computational Biology

edited by

Xingjian Chen

submission deadline 25 Jul 2026 | 2 articles | Viewed by 3007 | Submission Open

Keywords: bioinformatics; computational biology; machine learning in biomedicine; artificial intelligence; single-cell and spatial transcriptomics analysis; biological network analysis; high-throughput data analysis

Tissue and Organ Regeneration in Fish: Evolutionary Mechanisms

edited by Yujun Liang

submission deadline 30 Jul 2026 | 1 articles | Viewed by 7708 | Submission Open

Keywords: organ and tissue regeneration; regeneration mechanisms; progenitor cells; dedifferentiation; fishes; evolutionary adaptation; genetic regulation; signaling pathways; comparative genomics

(This special issue belongs to the Section Evolutionary Biology)

Plant Natural Products: Mechanisms of Action for Promoting Health

edited by

Francisco Les

and

Guillermo Cásedas

submission deadline 31 Jul 2026 | 16 articles | Viewed by 52511 | Submission Open

Keywords: phytochemicals; bioactivity; therapeutics; mechanisms; health promotion; metabolism; enzyme activity; bioactive compounds; pharmacognosy; plant extracts; polyphenols; ethnopharmacology; essential oils; aromatic plants; antioxidants; natural products

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Animal Models of Metabolic Diseases

edited by

Júlio Cezar De Oliveira

and

Melvin Khee Shing Leow

submission deadline 31 Jul 2026 | 8 articles | Viewed by 21009 | Submission Open

Keywords: experimental models; metabolic syndrome; insulin resistance; type 2 diabetes mellitus; obesity; dyslipidemia; hypertension; metabolic programming; DOHaD

(This special issue belongs to the Section Physiology)

Reproductive Physiology and Pathology in Livestock

edited by Claudio Gustavo Ustavo Barbeito and

Fabiano José Ferreira De Sant’Ana

submission deadline 31 Jul 2026 | 7 articles | Viewed by 13489 | Submission Open

Keywords: livestock; animal reproduction; reproductive biology; physiology and pathology of reproduction; experimental models; non-conventional species; biotechnology; immunology

(This special issue belongs to the Section Developmental and Reproductive Biology)

Human Leukocyte Antigen (HLA)—Antigen Interactions in Vaccine Development

edited by

Apostolos P. Georgopoulos

submission deadline 31 Jul 2026 | 6 articles | Viewed by 13284 | Submission Open

Keywords: HLA; vaccine; antigen; antibody; cancer; binding affinity; biophysical modeling; lymphocytes

Ecological Regulation of Forest and Grassland Pests

edited by

Dun Wang

and Liangjian Qu

submission deadline 31 Jul 2026 | 7 articles | Viewed by 11901 | Submission Open

Keywords: forest and grassland pests; ecological regulation; sustainable IPM; biological control; forest management

(This special issue belongs to the Section Ecology)

Unraveling the Molecular Mechanisms of Development and Stress Tolerance in Vegetables

edited by

Zhansheng Li

Jin Xu

and

Ying Li

submission deadline 31 Jul 2026 | 4 articles | Viewed by 11750 | Submission Open

Keywords: vegetable development; molecular mechanisms; stress tolerance; genetic regulation; epigenetic regulation; biochemical regulation; sustainable agriculture; environmental stress; growth adaptation; crop yield; gene editing; cellular engineering

(This special issue belongs to the Section Plant Science)

Phytoplasmas: Molecular Characterization and Host–Pathogen Interactions (2nd Edition)

edited by

Wei Wei

submission deadline 31 Jul 2026 | 5 articles | Viewed by 11684 | Submission Open

Keywords: molecular diagnosis and epidemiology; host-phytoplasma interactions; genetic diversity; taxonomy and classification; ecology and evolution; insect vectors; disease management; phytoplasma genomics and other omics studies

(This special issue belongs to the Section Microbiology)

The Biodiversity and Ecosystem Dynamics of Deep-Sea Hydrothermal Vents

edited by

Xiang Zeng

and Yadong Zhou

submission deadline 31 Jul 2026 | 4 articles | Viewed by 10247 | Submission Open

Keywords: deep-sea hydrothermal vents; biodiversity; microbiome; biological resources; marine biology

(This special issue belongs to the Section Marine and Freshwater Biology)

The Relationship Between Water Quality and Aquatic Organisms (2nd Edition)

edited by Dong Zhang,

Ming Duan

Miao Wang

Xiangsheng Hong

and Mengmeng Yi

submission deadline 31 Jul 2026 | 4 articles | Viewed by 9262 | Submission Open

Keywords: aquatic animals; water quality; phytoplankton; zooplankton; microorganisms; physiology

Milk Oligosaccharides: Biological Functions and Application Prospects

edited by

Chunsheng Jin

submission deadline 31 Jul 2026 | 3 articles | Viewed by 9067 | Submission Open

Keywords: milk oligosaccharides; colostrum; HMO; gut microbiota; immune modulator; prebiotics

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Cellular and Molecular Mechanisms in Sensory–Metabolic Integration: From Signaling Pathways to Systemic Regulation

edited by

Antonino Maniaci

, Giovanni Giurdanella, Mohamed Amin Zaoual and

Caterina Gagliano

submission deadline 31 Jul 2026 | 4 articles | Viewed by 8501 | Submission Open

Keywords: multisensory disorders; metabolic dysfunction; systemic health; sensory impairments; metabolic syndrome; neurometabolic pathways; vision impairment; hearing loss; vestibular disorders; olfactory dysfunction; gustatory dysfunction; somatosensory impairment; energy homeostasis; integrative medicine

(This special issue belongs to the Section Biochemistry and Molecular Biology)

The Future of Marine Megafauna

edited by

Vincent L. Bels

and

John R. Turner

submission deadline 31 Jul 2026 | 4 articles | Viewed by 7379 | Submission Open

Keywords: marine biodiversity; marine megafauna; anthropogenic impacts; conservation biology; marine ecosystems; behavioural ecology; marine protected areas (MPAs); ecological resilience; evolutionary biology; species recovery strategies

(This special issue belongs to the Section Zoology)

Osteoblast Differentiation in Health and Disease

edited by

Nadia Calabriso

and

Maria Annunziata Carluccio

submission deadline 31 Jul 2026 | 4 articles | Viewed by 7109 | Submission Open

Keywords: osteogenesis; mesenchymal stem cells; osteoblast; osteoblast differentiation; bone diseases; transcription factors; epigenetics; extracellular vesicles; inflammatory mediators; bioactive natural compounds

(This special issue belongs to the Section Biochemistry and Molecular Biology)

2nd Edition: Conservation and Evolution of Wildlife in the Context of Climate Change and Human Population Growth

edited by

Wen Bo Liao

submission deadline 31 Jul 2026 | 4 articles | Viewed by 5729 | Submission Open

Keywords: changes; local temperature; adaptation; evolution; animals; plants

(This special issue belongs to the Section Behavioural Biology)

Environmental and Nutritional Stress: Metabolic Consequences and Regulatory Strategies in Animals

edited by

Wenqiang Ma

submission deadline 31 Jul 2026 | 6 articles | Viewed by 5166 | Submission Open

Keywords: stress physiology; metabolic dysfunction; environmental stress; nutritional stress; gut microbiota; bioactive compounds

(This special issue belongs to the Section Physiology)

Advances in Plant Genomics and Genome Editing

edited by Xuean Cui

submission deadline 31 Jul 2026 | 9 articles | Viewed by 4984 | Submission Open

Keywords: plant genomes; plant genomics; genome sequencing; plant genome engineering; CRISPR/Cas; gene knock-out; gene knock-in; base editor; prime editor; genome editing tools; multiplex genome editing; gene expression regulation; plant trait improvement

(This special issue belongs to the Section Genetics and Genomics)

Tickborne Diseases and Their Vectors

edited by Moses Sibusiso Mtshali

submission deadline 31 Jul 2026 | 2 articles | Viewed by 4414 | Submission Open

Keywords: ticks; tickborne pathogens; epidemiology of tickborne diseases; zoonotic diseases; molecular diagnosis; genetic diversity; immunology; vector control and mapping

(This special issue belongs to the Section Infection Biology)

Advances in Foodborne Pathogens

edited by Qiming Chen

submission deadline 31 Jul 2026 | 3 articles | Viewed by 4361 | Submission Open

Keywords: foodborne pathogens; contamination mechanisms; infection mechanisms; detection assays; risk assessment; antibacterial agents or materials

(This special issue belongs to the Section Microbiology)

Research on Morphology and Sensorimotor Systems of Insect Antennae

edited by Lifeng Meng

submission deadline 31 Jul 2026 | 2 articles | Viewed by 3280 | Submission Open

Keywords: antennae structure; sensilla; olfaction; olfactory receptors; sensory integration; antenna lobe; pheromones; predator avoidance; foraging behavior

(This special issue belongs to the Section Zoology)

Advances in Redox Metabolism and Cellular Homeostasis

edited by

Alexios Vlamis-Gardikas

and

Jianqiang Xu

submission deadline 31 Jul 2026 | 1 articles | Viewed by 2964 | Submission Open

Keywords: oxidative stress; peroxiredoxins; hydrogen peroxide; redox regulation; thiol modification; reactive oxygen species; iron sulfur clusters; redox signaling

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Regulation of Gene Expression in Immune Cell Development and Function

edited by Bon Quy Trinh

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1830 | Submission Open

Keywords: noncoding RNA; enhancer; silencer; transposable element; epigenetics; chromatin structure and architecture; innate immunology; adaptive immunology; development; functions

(This special issue belongs to the Section Immunology)

Mode of Action of Allelopathic Compounds

edited by

Agnieszka Gniazdowska

and Paweł Staszek

submission deadline 31 Jul 2026 | 1 articles | Viewed by 883 | Submission Open

Keywords: metabolomics; phytotoxic potential; mode of action; sustainable bioherbicides; root exudates; plant–plant interaction; plant–microbe interaction; metabolic malformations; biosynthesis of allelochemicals

(This special issue belongs to the Section Plant Science)

Reprogramming Life: Synthetic Biology Approaches for Next-Gen Strain Engineering

edited by Thanaporn Laothanachareon,

Chitwadee Phithakrotchanakoon

and

Nunthaphan Vikromvarasiri

submission deadline 31 Jul 2026 | Viewed by 835 | Submission Open

Keywords: synthetic biology; strain engineering; metabolic pathway redesign; CRISPR/Cas genome editing; microbial cell factories; multi-omics integration; AI-driven metabolic design; sustainable bioproduction

(This special issue belongs to the Section Biotechnology)

Epilepsy: The Mechanisms of Seizure, Termination, and Biomarker Development

edited by

Keisuke Maeda

submission deadline 31 Jul 2026 | 1 articles | Viewed by 771 | Submission Open

Keywords: epilepsy; epileptogenesis; seizure mechanisms; seizure dynamics; termination; biomarkers; neural excitability; neuroscience

(This special issue belongs to the Section Neuroscience)

Aquatic Alien Invasions and Their Impact on Biodiversity and Ecosystem Services—3rd Edition

edited by

Giorgio Mancinelli

Paraskevi K. Karachle

Elena Tricarico

and

Baran Yoğurtçuoğlu

submission deadline 31 Jul 2026 | Viewed by 370 | Submission Open

Keywords: species; aquatic invasions; biodiversity; ecosystem services; conservation

(This special issue belongs to the Section Marine and Freshwater Biology)

Animal Cognition and Decision Strategies: From Behaviour to Computation

edited by

HaDi MaBouDi

and

Alice Bridges

submission deadline 31 Jul 2026 | Viewed by 301 | Submission Open

Keywords: animal models; bio-inspired computation; brain–behaviour mapping; cognitive mechanisms; cognitive neuroscience; cognitive strategies; comparative cognition; computational modelling; decision-making; learning and adaptation; naturalistic behaviour; neural computation; neuroethology

(This special issue belongs to the Section Neuroscience)

Applications of Gene Expression Profiling in Human Disease

edited by

Lipei Shao

submission deadline 31 Jul 2026 | Viewed by 270 | Submission Open

Keywords: gene expression profile; biomarkers; cancer; complex disease

(This special issue belongs to the Section Genetics and Genomics)

Ferroptosis: Mechanisms and Human Disease

edited by Chan-Yen Kuo

submission deadline 15 Aug 2026 | 5 articles | Viewed by 15944 | Submission Open

Keywords: ferroptosis; systemic diseases; inflammatory response; mitochondrial-dependent redox homeostasis; microenvironment

(This special issue belongs to the Section Cell Biology)

Gut Microbiota in Aquatic Animals Nutrition, Immunity, and Host–Microbe Interactions

edited by Qunlan Zhou

submission deadline 15 Aug 2026 | 3 articles | Viewed by 7384 | Submission Open

Keywords: gut microbiota; aquatic animal health; host–microbe interactions; functional probiotics; immunomodulation; nutrient metabolism; multi-omics integration; microbial ecology; environmental adaptation

(This special issue belongs to the Section Microbiology)

Changing Coral Reef Biodiversity and Function in the Anthropocene

edited by

Morgan Pratchett

submission deadline 15 Aug 2026 | 1 articles | Viewed by 1911 | Submission Open

Keywords: anthropogenic stressors; coral reefs; climate change; biodiversity loss; marine conservation; ecological adaptation; ecosystem function; resilience

(This special issue belongs to the Section Marine and Freshwater Biology)

Role of CARD9 in Health and Diseases

edited by Zuberwasim Sayyad and Nikhil Sharma

submission deadline 15 Aug 2026 | Viewed by 736 | Submission Open

Keywords: CARD9; innate immunity; pattern recognition receptors; autophagy; apoptosis; inflammasome; reactive oxygen species; post-translational modifications; gut microbiota; inflammation and cancer

Recent Advances in Angiogenesis and Vascular Development

edited by

Concetta Scimone

and

Rosalia D’Angelo

submission deadline 15 Aug 2026 | Viewed by 234 | Submission Open

Keywords: vasculogenesis; angiogenesis; vascular differentiation markers; endothelial-to-mesenchymal transition (EndMT); mechanotransduction; endothelial function; endothelial damage

(This special issue belongs to the Section Cell Biology)

The Role of Autophagy and Macrophages in Modulating Immune Responses in Atherosclerosis

edited by

Kumar Prabhash Jha

and Aatira Vijay

submission deadline 25 Aug 2026 | Viewed by 757 | Submission Open

Keywords: atherosclerosis; macrophages; autophagy; immune regulation; chronic inflammation; plaque stability; lipid metabolism; efferocytosis; immunometabolism

Population Genetics and Conservation of Amphibians and Reptiles

edited by

Fang Yan

submission deadline 25 Aug 2026 | Viewed by 379 | Submission Open

Keywords: conservation genetics; local adaptation; genetic diversity; amphibian; reptile; environmental change

(This special issue belongs to the Section Conservation Biology and Biodiversity)

Animal Models of Arthritis

edited by Nevena Arsenović-Ranin and Biljana Bufan

submission deadline 30 Aug 2026 | 4 articles | Viewed by 15663 | Submission Open

Keywords: animal models; rheumatoid arthritis; osteoarthritis; inflammation; immunopathology; pathological features; joints; treatment; drug screening; traditional medicine

(This special issue belongs to the Section Medical Biology)

Young Researchers in Neuroscience

edited by

Yansheng Du

submission deadline 31 Aug 2026 | 7 articles | Viewed by 69239 | Submission Open

Keywords: neurobiology; cell biology; molecular mechanisms; neural development; synaptic function; ion channels; neurotransmitter systems; gene expression; neuronal signaling; cellular physiology

(This special issue belongs to the Section Neuroscience)

Bone Cell Biology

edited by Yohei Abe and

Giulia Lanzolla

submission deadline 31 Aug 2026 | 8 articles | Viewed by 29144 | Submission Open

Keywords: osteoclast; osteoblast; osteocyte; bone density; macrophage; RANK; transcription factor; cell signaling

(This special issue belongs to the Section Cell Biology)

Biology, Ecology and Management of Harmful Algae

edited by Paul V. Zimba and

Jabulani R. Gumbo

submission deadline 31 Aug 2026 | 9 articles | Viewed by 17064 | Submission Open

Keywords: harmful algae; toxic algae; harmful algal bloom (HAB); excessive algae growth; microalgae and macroalgae; cyanobacteria; dinoflagellates; toxins; water quality; phytoplankton; water resources

Editorial Board Members’ Collection Series: Pathology of Cancer and Cardiovascular Disease

edited by

Mridula Chopra

Helen L. Fillmore

and

Maurizio Forte

submission deadline 31 Aug 2026 | 3 articles | Viewed by 13951 | Submission Open

Keywords: cancer; cardiovascular disease; biomarkers; gut microbiome; inflammation; health policy; diet and lifestyle

Insecticide Resistance: Molecular Mechanisms and Ecological Implications

edited by Kaikai Mao

submission deadline 31 Aug 2026 | 1 articles | Viewed by 9522 | Submission Open

Keywords: insecticide resistance; molecular mechanism; regulatory network; ecological impact; non-target impact; resistance genes; pest resistance management

(This special issue belongs to the Section Ecology)

Lipid Metabolism in Plant Growth and Development

edited by Xiaohong Yu and Yingqi Cai

submission deadline 31 Aug 2026 | 3 articles | Viewed by 7078 | Submission Open

Keywords: lipid metabolism; lipid engineering; plant growth; plant development; lipid biosynthesis; lipid signaling; lipid transport; membrane structure; energy storage; plant–microbe interactions; stress response; nutrition value; cellular process

(This special issue belongs to the Section Plant Science)

Advances in Cardiac and Vascular Biology: From Mechanisms to Pathophysiology

edited by

Hanqiang Deng

and

Haodi Wu

submission deadline 31 Aug 2026 | 4 articles | Viewed by 5360 | Submission Open

Keywords: cardiovascular biology; molecular mechanisms; cellular signaling; epigenomic regulation; vascular remodeling; metabolic reprogramming; cardiac pathophysiology

(This special issue belongs to the Section Physiology)

Advances in Leishmaniasis and Chagas Disease: Biology, Epidemiology, Treatment and Control (2nd Edition)

edited by

Fernando Almeida-Souza

Flávia de Oliveira Cardoso

and

Kátia Da Silva Calabrese

submission deadline 31 Aug 2026 | 1 articles | Viewed by 5270 | Submission Open

Keywords: leishmaniasis; Chagas disease; immunopathogeny; diagnosis; epidemiology; control; vaccine

Bone Mechanics: From Cells to Organs to Function

edited by

Viviana Toro-Ibacache

submission deadline 31 Aug 2026 | 5 articles | Viewed by 4872 | Submission Open

Keywords: bone mechanics; bone remodeling; mechanotransduction; structural analysis; functional morphology; bioengineering

(This special issue belongs to the Section Physiology)

Host–Microbiome–Environment Interactions in Domestic and Wild Animals

edited by

Cesar A. Rosales-Nieto

and Cesar A. Meza-Herrera

submission deadline 31 Aug 2026 | 4 articles | Viewed by 4867 | Submission Open

Keywords: animal microbiome; environmental microbiota; host–microbiota interactions; wildlife microbiology; livestock health and productivity; microbiome and conservation; One Health approach; gut microbiota dynamics; microbial ecology; microbiome and reproduction; habitat–host microbiome linkages; multi-omics integration

(This special issue belongs to the Section Microbiology)

Mitochondrial Genomics of Arthropods

edited by Renfu Shao

submission deadline 31 Aug 2026 | 5 articles | Viewed by 4175 | Submission Open

Keywords: mitochondrial genome architecture; transcriptional dynamics; translational mechanisms; comparative genomics; molecular evolution; arthropod phylogenetics; systematics; evolutionary biology

(This special issue belongs to the Section Genetics and Genomics)

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